WO2001040769A3 - Hochdurchsatzscreening-verfahren und -vorrichtung zur optischen erfassung von proben - Google Patents

Hochdurchsatzscreening-verfahren und -vorrichtung zur optischen erfassung von proben Download PDF

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Publication number
WO2001040769A3
WO2001040769A3 PCT/EP2000/012126 EP0012126W WO0140769A3 WO 2001040769 A3 WO2001040769 A3 WO 2001040769A3 EP 0012126 W EP0012126 W EP 0012126W WO 0140769 A3 WO0140769 A3 WO 0140769A3
Authority
WO
WIPO (PCT)
Prior art keywords
electromagnetic radiation
multitude
radiation
high rate
screening method
Prior art date
Application number
PCT/EP2000/012126
Other languages
English (en)
French (fr)
Other versions
WO2001040769A2 (de
Inventor
Norbert Garbow
Original Assignee
Evotec Biosystems Ag
Norbert Garbow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Biosystems Ag, Norbert Garbow filed Critical Evotec Biosystems Ag
Priority to AU28396/01A priority Critical patent/AU2839601A/en
Publication of WO2001040769A2 publication Critical patent/WO2001040769A2/de
Publication of WO2001040769A3 publication Critical patent/WO2001040769A3/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence

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  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Für das Hochdurchsatzscreening wird eine erste elektromagnetische Strahlung mit mindestens einer Strahlungserzeugungsvorrichtung (31) erzeugt und diese simultan in einer Vielzahl von ersten optischen Fasern (34) zu mindestens einer Strahlteilervorrichtung (36) geleitet, von der ausgehend die erste elektromagnetische Strahlung simultan in einer Vielzahl von zweiten optischen Fasern (48) zu einer Fokussieroptik (56) geleitet wird. Die erste elektromagnetische Strahlung wird mittels der Fokussieroptik (56) simultan in eine Vielzahl von Foki (60) fokussiert, die innerhalb zu erfassender Probenmessvolumina liegen. Von den Probenmessvolumina emittierte zweite elektromagnetische Strahlung wird mittels der Vielzahl von zweiten optischen Fasern (48) von der Fokussieroptik (56) zu der mindestens einen Strahlteilervorrichtung (36) geleitet, von der ausgehend die zweite elektromagnetische Strahlung zu getrennten Detektorbereichen (70) mindestens einer Detektorvorrichtung (72) weitergeleitet wird, die außerhalb des sich von der mindestens einen Strahlungserzeugungsvorrichtung (31) über die mindestens eine Strahlteilervorrichtung (36) bis zur Fokussieroptik (56) erstreckenden Strahlenganges angeordnet sind und die die zweite elektromagnetische Strahlung erfassen. Die Messdaten, die auf der Grundlage der erfassten zweiten elektromagnetischen Strahlung generiert werden, werden verarbeitet.
PCT/EP2000/012126 1999-12-02 2000-12-02 Hochdurchsatzscreening-verfahren und -vorrichtung zur optischen erfassung von proben WO2001040769A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28396/01A AU2839601A (en) 1999-12-02 2000-12-02 High rate screening method and device for optically detecting samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19957974 1999-12-02
DE19957974.1 1999-12-02

Publications (2)

Publication Number Publication Date
WO2001040769A2 WO2001040769A2 (de) 2001-06-07
WO2001040769A3 true WO2001040769A3 (de) 2001-12-13

Family

ID=7931093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/012126 WO2001040769A2 (de) 1999-12-02 2000-12-02 Hochdurchsatzscreening-verfahren und -vorrichtung zur optischen erfassung von proben

Country Status (3)

Country Link
AU (1) AU2839601A (de)
DE (1) DE20022966U1 (de)
WO (1) WO2001040769A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US7745221B2 (en) 2003-08-28 2010-06-29 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
EP1889111A2 (de) 2005-05-25 2008-02-20 Massachusetts Institute of Technology Multifokale bildgebungssysteme und -verfahren
WO2016145366A1 (en) 2015-03-11 2016-09-15 Timothy Ragan System and methods for serial staining and imaging

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5161053A (en) * 1988-08-01 1992-11-03 Commonwealth Scientific & Industrial Research Confocal microscope
US5430816A (en) * 1992-10-27 1995-07-04 Matsushita Electric Industrial Co., Ltd. Multiple split-beam laser processing apparatus generating an array of focused beams
US5589351A (en) * 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
US5780857A (en) * 1996-10-04 1998-07-14 Wallac Oy Apparatus for imaging biochemical samples on substrates
JPH11271227A (ja) * 1998-03-19 1999-10-05 Hamamatsu Photonics Kk 蛍光測定装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5161053A (en) * 1988-08-01 1992-11-03 Commonwealth Scientific & Industrial Research Confocal microscope
US5430816A (en) * 1992-10-27 1995-07-04 Matsushita Electric Industrial Co., Ltd. Multiple split-beam laser processing apparatus generating an array of focused beams
US5589351A (en) * 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
US5780857A (en) * 1996-10-04 1998-07-14 Wallac Oy Apparatus for imaging biochemical samples on substrates
JPH11271227A (ja) * 1998-03-19 1999-10-05 Hamamatsu Photonics Kk 蛍光測定装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 01 31 January 2000 (2000-01-31) *

Also Published As

Publication number Publication date
WO2001040769A2 (de) 2001-06-07
DE20022966U1 (de) 2002-08-22
AU2839601A (en) 2001-06-12

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