WO2001040757A3 - Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods - Google Patents

Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods Download PDF

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Publication number
WO2001040757A3
WO2001040757A3 PCT/US2000/041138 US0041138W WO0140757A3 WO 2001040757 A3 WO2001040757 A3 WO 2001040757A3 US 0041138 W US0041138 W US 0041138W WO 0140757 A3 WO0140757 A3 WO 0140757A3
Authority
WO
WIPO (PCT)
Prior art keywords
resonant optical
optical cavities
biosensors
methods
cavities
Prior art date
Application number
PCT/US2000/041138
Other languages
French (fr)
Other versions
WO2001040757A2 (en
Inventor
Steven M Blair
Original Assignee
Univ Utah Res Found
Steven M Blair
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found, Steven M Blair filed Critical Univ Utah Res Found
Priority to JP2001542173A priority Critical patent/JP2003515737A/en
Priority to AU45032/01A priority patent/AU4503201A/en
Priority to US10/089,497 priority patent/US7384797B1/en
Priority to CA002384977A priority patent/CA2384977A1/en
Priority to EP00992472A priority patent/EP1221051A4/en
Publication of WO2001040757A2 publication Critical patent/WO2001040757A2/en
Publication of WO2001040757A3 publication Critical patent/WO2001040757A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/7746—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the waveguide coupled to a cavity resonator

Abstract

Biosensors including resonant optical cavities. The resonant optical cavities are shaped so as to generate whispering gallery modes, which increase the quality factors of the cavities and facilitate the detection of analytes in a sample with enhanced sensitivity. The sizes of the resonant optical cavities facilitate their use in biosensors that include arrays of sensing zones. Accordingly, the resonant optical cavities may be used in high-density sensing arrays that can be read in real-time and in parallel. Thus, the resonant optical cavities are useful for detecting small concentrations of samples in real-time and with high throughput. Different embodiments of the biosensors are also disclosed, as are methods for using the biosensors.
PCT/US2000/041138 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods WO2001040757A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001542173A JP2003515737A (en) 1999-10-14 2000-10-12 Resonant optical cavity for sensitive and high-throughput biological sensors and methods
AU45032/01A AU4503201A (en) 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods
US10/089,497 US7384797B1 (en) 2000-10-12 2000-10-12 Resonant optical cavities for high-sensitivity high-throughput biological sensors and methods
CA002384977A CA2384977A1 (en) 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods
EP00992472A EP1221051A4 (en) 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15936699P 1999-10-14 1999-10-14
US60/159,366 1999-10-14

Publications (2)

Publication Number Publication Date
WO2001040757A2 WO2001040757A2 (en) 2001-06-07
WO2001040757A3 true WO2001040757A3 (en) 2002-03-14

Family

ID=22572303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041138 WO2001040757A2 (en) 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods

Country Status (5)

Country Link
EP (1) EP1221051A4 (en)
JP (1) JP2003515737A (en)
AU (1) AU4503201A (en)
CA (1) CA2384977A1 (en)
WO (1) WO2001040757A2 (en)

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US7283707B1 (en) 2001-07-25 2007-10-16 Oewaves, Inc. Evanescently coupling light between waveguides and whispering-gallery mode optical resonators
US6853479B1 (en) 2001-08-30 2005-02-08 Oewaves, Inc. Apparatus and method for coupling light between an optical resonator and a semiconductor chip with a minimum number of components and alignment steps
US7399445B2 (en) 2002-01-11 2008-07-15 Canon Kabushiki Kaisha Chemical sensor
US6879752B1 (en) 2002-04-03 2005-04-12 Oewaves, Inc. Film spacer for setting the gap between an optical coupler and a whispering-gallery mode optical resonator
US20040184711A1 (en) 2002-06-20 2004-09-23 Kenneth Bradley Optical switches and routers and optical filters
US7781217B2 (en) * 2002-10-02 2010-08-24 California Institute Of Technology Biological and chemical microcavity resonant sensors and methods of detecting molecules
CN1703810A (en) 2002-10-11 2005-11-30 佳能株式会社 Sensor
US20050070027A1 (en) 2003-09-30 2005-03-31 Jacques Gollier Double resonance interrogation of grating-coupled waveguides
US7259855B2 (en) 2003-10-14 2007-08-21 3M Innovative Properties Company Porous microsphere resonators
US7444045B2 (en) 2003-10-14 2008-10-28 3M Innovative Properties Company Hybrid sphere-waveguide resonators
MXPA06013728A (en) 2004-05-26 2007-05-09 Genera Biosystems Pty Ltd Biosensor using whispering gallery modes in microspheres.
AU2005248419C1 (en) * 2004-05-26 2011-03-10 Genera Biosystems Limited Biosensor using whispering gallery modes in microspheres
US7271379B2 (en) 2004-05-27 2007-09-18 3M Innovative Properties Company Dielectric microcavity fluorosensors excited with a broadband light source
US7352933B2 (en) 2004-05-27 2008-04-01 3M Innovative Properties Company Dielectric microcavity sensors
US7257279B2 (en) 2004-09-20 2007-08-14 3M Innovative Properties Company Systems and methods for biosensing and microresonator sensors for same
JP4565061B2 (en) * 2004-10-06 2010-10-20 地方独立行政法人山口県産業技術センター Optical branch circuit and sensor
JP2007047051A (en) * 2005-08-10 2007-02-22 Nippon Telegr & Teleph Corp <Ntt> Multilayer refractive index measuring device
US7389025B2 (en) 2006-03-29 2008-06-17 3M Innovative Properties Company Coupling light into microresonators
US7532790B2 (en) 2006-03-29 2009-05-12 3M Innovative Properties Company Method of coupling light into microresonators
US7512298B2 (en) 2006-12-01 2009-03-31 3M Innovative Properties Company Optical sensing methods
US7903240B2 (en) 2006-12-01 2011-03-08 3M Innovative Properties Company Optical sensing device
US7486855B2 (en) 2006-12-27 2009-02-03 3M Innovative Properties Company Optical microresonator
US7903906B2 (en) 2006-12-01 2011-03-08 3M Innovative Properties Company Optical sensing devices and methods
US7702202B2 (en) 2006-12-01 2010-04-20 3M Innovative Properties Company Optical microresonator
US7933022B2 (en) 2006-12-01 2011-04-26 3M Innovative Properties Company Integrated optical disk resonator
US7778499B2 (en) * 2007-05-21 2010-08-17 National Research Council Of Canada Silicon photonic wire waveguide biosensor
US7796262B1 (en) 2007-05-31 2010-09-14 Nomadics, Inc. Integrated optical resonator device for measuring chemical and biological analyte concentrations
JP5424229B2 (en) * 2007-09-28 2014-02-26 独立行政法人産業技術総合研究所 Optical waveguide mode sensor using oxide film and manufacturing method thereof
US8107081B2 (en) 2007-10-01 2012-01-31 California Institute Of Technology Micro-cavity gas and vapor sensors and detection methods
CN101849177B (en) * 2007-11-06 2012-07-04 Nxp股份有限公司 A biosensor device and a method of detecting biological particles
US8092855B2 (en) 2007-11-28 2012-01-10 California Institute Of Technology Click chemistry surface functionalization for resonant micro-cavity sensors
WO2009084721A1 (en) * 2007-12-31 2009-07-09 Fujirebio Inc. Clusters of microresonators for cavity mode optical sensing
US8593638B2 (en) 2008-10-02 2013-11-26 California Institute Of Technology Split frequency sensing methods and systems
EP2352990B1 (en) * 2008-11-05 2020-12-30 Michael Himmelhaus Method for sensing a biochemical and/or biomechanical process of a live biological cell
US8368899B2 (en) * 2009-08-18 2013-02-05 Ofs Fitel, Llc Coiled evanescent optical sensor
WO2013080432A1 (en) * 2011-11-28 2013-06-06 ソニー株式会社 Chemical sensor, chemical sensor module, chemical substance detector, and chemical substance detection method
CN102841054B (en) * 2012-09-27 2015-07-29 复旦大学 A kind of biochemical sensor of coupled micro-cavity photon molecule
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US5525466A (en) * 1991-06-07 1996-06-11 Ciba Corning Diagnostics Corp. Multiple output referencing system for evanescent wave sensor
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See also references of EP1221051A4 *

Also Published As

Publication number Publication date
EP1221051A2 (en) 2002-07-10
WO2001040757A2 (en) 2001-06-07
CA2384977A1 (en) 2001-06-07
EP1221051A4 (en) 2003-03-05
JP2003515737A (en) 2003-05-07
AU4503201A (en) 2001-06-12

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