WO2001036471A3 - Endogenous and non-endogenous versions of human g protein-coupled receptors - Google Patents

Endogenous and non-endogenous versions of human g protein-coupled receptors Download PDF

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Publication number
WO2001036471A3
WO2001036471A3 PCT/US2000/031509 US0031509W WO0136471A3 WO 2001036471 A3 WO2001036471 A3 WO 2001036471A3 US 0031509 W US0031509 W US 0031509W WO 0136471 A3 WO0136471 A3 WO 0136471A3
Authority
WO
WIPO (PCT)
Prior art keywords
endogenous
human
protein
versions
coupled receptors
Prior art date
Application number
PCT/US2000/031509
Other languages
French (fr)
Other versions
WO2001036471A2 (en
Inventor
Ruoping Chen
Huong T Dang
Kevin P Lowitz
Original Assignee
Arena Pharm Inc
Ruoping Chen
Huong T Dang
Kevin P Lowitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002390547A priority Critical patent/CA2390547A1/en
Application filed by Arena Pharm Inc, Ruoping Chen, Huong T Dang, Kevin P Lowitz filed Critical Arena Pharm Inc
Priority to AU17696/01A priority patent/AU782959B2/en
Priority to IL14956900A priority patent/IL149569A0/en
Priority to NZ531722A priority patent/NZ531722A/en
Priority to NZ518662A priority patent/NZ518662A/en
Priority to PCT/US2000/031509 priority patent/WO2001036471A2/en
Priority to JP2001538960A priority patent/JP4768946B2/en
Priority to CNB00815869XA priority patent/CN1310945C/en
Priority to EP00980434A priority patent/EP1242448A2/en
Publication of WO2001036471A2 publication Critical patent/WO2001036471A2/en
Publication of WO2001036471A3 publication Critical patent/WO2001036471A3/en
Priority to AU2005244540A priority patent/AU2005244540B2/en
Priority to AU2010201829A priority patent/AU2010201829B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown ('orphan GPCR receptors'), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.
PCT/US2000/031509 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors WO2001036471A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
PCT/US2000/031509 WO2001036471A2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors
AU17696/01A AU782959B2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human G protein-coupled receptors
IL14956900A IL149569A0 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors
NZ531722A NZ531722A (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human G protein-coupled receptors
NZ518662A NZ518662A (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human G protein-coupled receptors
CA002390547A CA2390547A1 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors
JP2001538960A JP4768946B2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous forms of the human G protein coupled receptor
CNB00815869XA CN1310945C (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human G protein-coupled receptors
EP00980434A EP1242448A2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors
AU2005244540A AU2005244540B2 (en) 1999-11-17 2005-12-15 Endogenous and non-endogenous versions of human G protein-coupled receptors
AU2010201829A AU2010201829B2 (en) 1999-11-17 2010-05-07 Endogenous and non-endogenous versions of human G protein-coupled receptors

Applications Claiming Priority (45)

Application Number Priority Date Filing Date Title
US16636999P 1999-11-17 1999-11-17
US16609999P 1999-11-17 1999-11-17
US16608899P 1999-11-17 1999-11-17
US60/166,099 1999-11-17
US60/166,088 1999-11-17
US60/166,369 1999-11-17
US17190199P 1999-12-23 1999-12-23
US17190299P 1999-12-23 1999-12-23
US17190099P 1999-12-23 1999-12-23
US60/171,901 1999-12-23
US60/171,902 1999-12-23
US60/171,900 1999-12-23
US18174900P 2000-02-11 2000-02-11
US60/181,749 2000-02-11
US18925800P 2000-03-14 2000-03-14
US18925900P 2000-03-14 2000-03-14
US60/189,259 2000-03-14
US60/189,258 2000-03-14
US19589900P 2000-04-10 2000-04-10
US19589800P 2000-04-10 2000-04-10
US19607800P 2000-04-10 2000-04-10
US60/196,078 2000-04-10
US60/195,898 2000-04-10
US60/195,899 2000-04-10
US20041900P 2000-04-28 2000-04-28
US60/200,419 2000-04-28
US20363000P 2000-05-12 2000-05-12
US60/203,630 2000-05-12
US21098200P 2000-06-12 2000-06-12
US21074100P 2000-06-12 2000-06-12
US60/210,741 2000-06-12
US60/210,982 2000-06-12
US22676000P 2000-08-21 2000-08-21
US60/226,760 2000-08-21
US23541800P 2000-09-26 2000-09-26
US23577900P 2000-09-26 2000-09-26
US60/235,779 2000-09-26
US60/235,418 2000-09-26
US24234300P 2000-10-20 2000-10-20
US24233200P 2000-10-20 2000-10-20
US60/242,343 2000-10-20
US60/242,332 2000-10-20
US24301900P 2000-10-24 2000-10-24
US60/243,019 2000-10-24
PCT/US2000/031509 WO2001036471A2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors

Publications (2)

Publication Number Publication Date
WO2001036471A2 WO2001036471A2 (en) 2001-05-25
WO2001036471A3 true WO2001036471A3 (en) 2002-01-03

Family

ID=35884102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031509 WO2001036471A2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors

Country Status (7)

Country Link
EP (1) EP1242448A2 (en)
CN (1) CN1310945C (en)
AU (3) AU782959B2 (en)
CA (1) CA2390547A1 (en)
IL (1) IL149569A0 (en)
NZ (2) NZ531722A (en)
WO (1) WO2001036471A2 (en)

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