WO2001036446A3 - Use of g-protein coupled receptors (gpcrs) and modified gpcrs for the treatment of diseases - Google Patents

Use of g-protein coupled receptors (gpcrs) and modified gpcrs for the treatment of diseases Download PDF

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Publication number
WO2001036446A3
WO2001036446A3 PCT/GB2000/004385 GB0004385W WO0136446A3 WO 2001036446 A3 WO2001036446 A3 WO 2001036446A3 GB 0004385 W GB0004385 W GB 0004385W WO 0136446 A3 WO0136446 A3 WO 0136446A3
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WO
WIPO (PCT)
Prior art keywords
gpcrs
diseases
protein coupled
coupled receptors
treatment
Prior art date
Application number
PCT/GB2000/004385
Other languages
French (fr)
Other versions
WO2001036446A2 (en
Inventor
Craig Alexander Mcardle
Original Assignee
Univ Bristol
Craig Alexander Mcardle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bristol, Craig Alexander Mcardle filed Critical Univ Bristol
Priority to AU14050/01A priority Critical patent/AU1405001A/en
Publication of WO2001036446A2 publication Critical patent/WO2001036446A2/en
Publication of WO2001036446A3 publication Critical patent/WO2001036446A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed is the use of vector encoding G-protein coupled receptors (GPCRs) in treating a variety of GPCR influenced diseases.
PCT/GB2000/004385 1999-11-17 2000-11-17 Use of g-protein coupled receptors (gpcrs) and modified gpcrs for the treatment of diseases WO2001036446A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14050/01A AU1405001A (en) 1999-11-17 2000-11-17 Treatment of diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9927215.5 1999-11-17
GBGB9927215.5A GB9927215D0 (en) 1999-11-17 1999-11-17 Hormone receptor expression

Publications (2)

Publication Number Publication Date
WO2001036446A2 WO2001036446A2 (en) 2001-05-25
WO2001036446A3 true WO2001036446A3 (en) 2002-05-10

Family

ID=10864694

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004385 WO2001036446A2 (en) 1999-11-17 2000-11-17 Use of g-protein coupled receptors (gpcrs) and modified gpcrs for the treatment of diseases

Country Status (3)

Country Link
AU (1) AU1405001A (en)
GB (1) GB9927215D0 (en)
WO (1) WO2001036446A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10292896D2 (en) * 2001-07-05 2004-07-01 Univ Goettingen Georg August Gene therapy method for the treatment of GnRH receptor-positive carcinomas by GnRH-induced tumor cell-specific activation of a therapeutic gene, associated nucleic acid constructs and vectors
EP1273309A1 (en) * 2001-07-05 2003-01-08 Georg-August Universität Göttingen Gene therapeutic method for the treatment of GnRH-receptor positve carcinomas through GnRH induced tumor cell specific activation of a therapeutic gene, corresponding nucleic acids and vectors
US20030108928A1 (en) * 2001-10-09 2003-06-12 Millennium Pharmaceuticals, Inc. MID 241 receptor, a novel G-protein coupled receptor
WO2009050309A1 (en) 2007-10-17 2009-04-23 Universidad De Cordoba Isoforms of human somatostatin receptor type 5 produced by alternative processing and oligonucleotide pairs for detection thereof by pcr
WO2016111657A1 (en) * 2015-01-08 2016-07-14 Iyison Necla Birgul Use of allatostatin receptor in cancer treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013130A1 (en) * 1991-12-31 1993-07-08 Arch Development Corporation Somatostatin receptors
WO1994000590A1 (en) * 1992-06-23 1994-01-06 The Mt. Sinai School Of Medicine Of The City University Of New York Cloning and expression of gonadotropin-releasing hormone receptor
WO1996025423A1 (en) * 1995-02-17 1996-08-22 Mount Sinai School Of Medicine Of The City University Of New York Inhibition and modulation of gonadotropin-releasing hormone receptor activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013130A1 (en) * 1991-12-31 1993-07-08 Arch Development Corporation Somatostatin receptors
WO1994000590A1 (en) * 1992-06-23 1994-01-06 The Mt. Sinai School Of Medicine Of The City University Of New York Cloning and expression of gonadotropin-releasing hormone receptor
WO1996025423A1 (en) * 1995-02-17 1996-08-22 Mount Sinai School Of Medicine Of The City University Of New York Inhibition and modulation of gonadotropin-releasing hormone receptor activity

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BENALI NAOUAL ET AL: "Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 16, 1 August 2000 (2000-08-01), August 1, 2000, pages 9180 - 9185, XP002165128, ISSN: 0027-8424 *
FROIDEVAUX SYLVIE ET AL: "Differential regulation of somatostatin receptor type 2 (sst 2) expression in AR4-2J tumor cells implanted into mice during octreotide treatment.", CANCER RESEARCH, vol. 59, no. 15, 1 August 1999 (1999-08-01), pages 3652 - 3657, XP000942216, ISSN: 0008-5472 *
HISLOP JAMES N ET AL: "Desensitization and internalization of human and Xenopus gonadotropin-releasing hormone receptors expressed in alphaT4 pituitary cells using recombinant adenovirus.", ENDOCRINOLOGY, vol. 141, no. 12, December 2000 (2000-12-01), pages 4564 - 4575, XP000985167, ISSN: 0013-7227 *
LIN XINWEI ET AL: "Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation.", MOLECULAR ENDOCRINOLOGY, vol. 12, no. 2, February 1998 (1998-02-01), pages 161 - 171, XP002118584, ISSN: 0888-8809 *
MCARDLE CRAIG A ET AL: "The tail of the gonadotrophin-releasing hormone receptor: Desensitization at, and distal to, G protein-coupled receptors.", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 151, no. 1-2, 25 May 1999 (1999-05-25), pages 129 - 136, XP000984767, ISSN: 0303-7207 *
PAUWELS P J ET AL: "REVIEW:AMINO ACID DOMAINS INVOLVED IN CONSTITUTIVE ACTIVATION OF G-PROTEIN-COUPLED RECEPTORS", MOLECULAR NEUROBIOLOGY,US,HUMANA PRESS, vol. 17, no. 1/03, 1998, pages 109 - 135, XP000866477, ISSN: 0893-7648 *
SCHEER A ET AL: "CONSTITUTIVELY ACTIVE G PROTEIN-COUPLED RECEPTORS: POTENTIAL MECHANISMS OF RECEPTOR ACTIVATION", JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH,US,MARCEL DEKKER, NEW YORK, NY, vol. 17, no. 1/03, 1997, pages 57 - 73, XP000867531, ISSN: 1079-9893 *

Also Published As

Publication number Publication date
WO2001036446A2 (en) 2001-05-25
AU1405001A (en) 2001-05-30
GB9927215D0 (en) 2000-01-12

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