WO2001032258A3 - Transcranial ultrasound thrombolysis system and method of treating a stroke - Google Patents

Transcranial ultrasound thrombolysis system and method of treating a stroke Download PDF

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Publication number
WO2001032258A3
WO2001032258A3 PCT/US2000/030104 US0030104W WO0132258A3 WO 2001032258 A3 WO2001032258 A3 WO 2001032258A3 US 0030104 W US0030104 W US 0030104W WO 0132258 A3 WO0132258 A3 WO 0132258A3
Authority
WO
WIPO (PCT)
Prior art keywords
transcranial ultrasound
ultrasound thrombolysis
stroke
treating
branches
Prior art date
Application number
PCT/US2000/030104
Other languages
French (fr)
Other versions
WO2001032258A2 (en
Inventor
Christy K Holland
Daniel S Kanter
Lawrence J Busse
Kenneth R Wagner
Original Assignee
Univ Cincinnati
Christy K Holland
Daniel S Kanter
Lawrence J Busse
Kenneth R Wagner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cincinnati, Christy K Holland, Daniel S Kanter, Lawrence J Busse, Kenneth R Wagner filed Critical Univ Cincinnati
Priority to EP00978327A priority Critical patent/EP1225837A2/en
Priority to JP2001534461A priority patent/JP2003523794A/en
Priority to US10/111,722 priority patent/US7300414B1/en
Priority to CA2389669A priority patent/CA2389669C/en
Priority to AU15799/01A priority patent/AU1579901A/en
Publication of WO2001032258A2 publication Critical patent/WO2001032258A2/en
Publication of WO2001032258A3 publication Critical patent/WO2001032258A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00084—Temperature
    • A61B2017/00092—Temperature using thermocouples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids

Abstract

A method of transcranial ultrasound thrombolysis comprises the steps of providing a predetermined level of ultrasonic energy substantially throughout a primary treatment zone encompassing the M1 branch and M2 branches of the middle cerebral artery of an individual. A thrombolytic agent is also administered to the individual. A transcranial ultrasound thrombolysis system (10) is also provided that includes a transducer (20). The transducer is adapted to provide a predetermined level of ultrasonic energy substantially throughout a primary treatment zone encompassing at least a substantial portion of the M1 branch and the M2 branches of the middle cerebral artery in one hemisphere of a brain.
PCT/US2000/030104 1999-11-01 2000-11-01 Transcranial ultrasound thrombolysis system and method of treating a stroke WO2001032258A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP00978327A EP1225837A2 (en) 1999-11-01 2000-11-01 Transcranial ultrasound thrombolysis system and method of treating a stroke
JP2001534461A JP2003523794A (en) 1999-11-01 2000-11-01 Thrombus disintegration system and method for treating seizures by intracranial ultrasound irradiation
US10/111,722 US7300414B1 (en) 1999-11-01 2000-11-01 Transcranial ultrasound thrombolysis system and method of treating a stroke
CA2389669A CA2389669C (en) 1999-11-01 2000-11-01 Transcranial ultrasound thrombolysis system and method of treating a stroke
AU15799/01A AU1579901A (en) 1999-11-01 2000-11-01 Transcranial ultrasound thrombolysis system and method of treating a stroke

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16297699P 1999-11-01 1999-11-01
US60/162,976 1999-11-01
US24198600P 2000-10-20 2000-10-20
US60/241,986 2000-10-20

Publications (2)

Publication Number Publication Date
WO2001032258A2 WO2001032258A2 (en) 2001-05-10
WO2001032258A3 true WO2001032258A3 (en) 2002-01-24

Family

ID=26859208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030104 WO2001032258A2 (en) 1999-11-01 2000-11-01 Transcranial ultrasound thrombolysis system and method of treating a stroke

Country Status (5)

Country Link
EP (1) EP1225837A2 (en)
JP (1) JP2003523794A (en)
AU (1) AU1579901A (en)
CA (1) CA2389669C (en)
WO (1) WO2001032258A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050124897A1 (en) * 2003-12-03 2005-06-09 Scimed Life Systems, Inc. Apparatus and methods for delivering acoustic energy to body tissue
JP4492818B2 (en) * 2004-06-21 2010-06-30 博 古幡 Ultrasound cerebral infarction treatment device
AU2006246311B2 (en) * 2005-05-12 2008-08-21 Compumedics Medical Innovations Pty Ltd Ultrasound diagnosis and treatment apparatus
EP1885248B1 (en) * 2005-05-12 2014-12-31 Compumedics Medical Innovations Pty Ltd Ultrasound diagnosis and treatment apparatus
US9630028B2 (en) * 2006-08-11 2017-04-25 Koninklijke Philips N.V. Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis
KR101121379B1 (en) 2009-09-03 2012-03-09 삼성메디슨 주식회사 Ultrasound system and method for providing a plurality of plane images corresponding to a plurality of view
JP2012200454A (en) * 2011-03-25 2012-10-22 Hitachi Medical Corp Drug injection apparatus and drug injection system
CN111836666A (en) * 2017-11-09 2020-10-27 蒙特非奥里医疗中心 Low energy immunosensitization for the treatment of cancer and metastasis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217018A (en) * 1989-05-16 1993-06-08 Hewlett-Packard Company Acoustic transmission through cladded core waveguide
US5313944A (en) * 1992-09-21 1994-05-24 Biomagnetic Technologies, Inc. Measurement of internal body structure during biomagnetometry
US5944687A (en) * 1996-04-24 1999-08-31 The Regents Of The University Of California Opto-acoustic transducer for medical applications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217018A (en) * 1989-05-16 1993-06-08 Hewlett-Packard Company Acoustic transmission through cladded core waveguide
US5313944A (en) * 1992-09-21 1994-05-24 Biomagnetic Technologies, Inc. Measurement of internal body structure during biomagnetometry
US5944687A (en) * 1996-04-24 1999-08-31 The Regents Of The University Of California Opto-acoustic transducer for medical applications

Also Published As

Publication number Publication date
EP1225837A2 (en) 2002-07-31
CA2389669A1 (en) 2001-05-10
CA2389669C (en) 2010-06-01
AU1579901A (en) 2001-05-14
JP2003523794A (en) 2003-08-12
WO2001032258A2 (en) 2001-05-10

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