WO2001014414A3 - Human abc2 transporter and uses thereof - Google Patents

Human abc2 transporter and uses thereof Download PDF

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Publication number
WO2001014414A3
WO2001014414A3 PCT/CA2000/000962 CA0000962W WO0114414A3 WO 2001014414 A3 WO2001014414 A3 WO 2001014414A3 CA 0000962 W CA0000962 W CA 0000962W WO 0114414 A3 WO0114414 A3 WO 0114414A3
Authority
WO
WIPO (PCT)
Prior art keywords
abc2 transporter
nucleic acid
acid molecules
transporter
abc2
Prior art date
Application number
PCT/CA2000/000962
Other languages
French (fr)
Other versions
WO2001014414A2 (en
Inventor
Bihan Stephane Le
Catriona Wilson
David L Charest
Original Assignee
Activepass Pharmaceuticals Inc
Bihan Stephane Le
Catriona Wilson
David L Charest
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Activepass Pharmaceuticals Inc, Bihan Stephane Le, Catriona Wilson, David L Charest filed Critical Activepass Pharmaceuticals Inc
Priority to JP2001518743A priority Critical patent/JP2003509017A/en
Priority to AU66771/00A priority patent/AU6677100A/en
Priority to EP00954219A priority patent/EP1210422A2/en
Priority to CA002383063A priority patent/CA2383063A1/en
Publication of WO2001014414A2 publication Critical patent/WO2001014414A2/en
Publication of WO2001014414A3 publication Critical patent/WO2001014414A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides isolated nucleic acid molecules, designated ABC2 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABC2 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ABC2 transporter gene has been introduced or disrupted. The invention still further provides isolated ABC2 transporter proteins, fusion proteins, antigenic peptides, anti-ABC2 transporter antibodies, and screening assays for ABC2 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
PCT/CA2000/000962 1999-08-20 2000-08-18 Human abc2 transporter and uses thereof WO2001014414A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001518743A JP2003509017A (en) 1999-08-20 2000-08-18 Human ABC2 transporter and uses thereof
AU66771/00A AU6677100A (en) 1999-08-20 2000-08-18 Novel abc2 transporter and uses thereof
EP00954219A EP1210422A2 (en) 1999-08-20 2000-08-18 Human abc2 transporter and uses thereof
CA002383063A CA2383063A1 (en) 1999-08-20 2000-08-18 Human abc2 transporter and uses thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US15007399P 1999-08-20 1999-08-20
US60/150,073 1999-08-20
US15145799P 1999-08-30 1999-08-30
US60/151,457 1999-08-30
US64104000A 2000-08-17 2000-08-17
US09/641,040 2000-08-17

Publications (2)

Publication Number Publication Date
WO2001014414A2 WO2001014414A2 (en) 2001-03-01
WO2001014414A3 true WO2001014414A3 (en) 2001-07-19

Family

ID=27386911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000962 WO2001014414A2 (en) 1999-08-20 2000-08-18 Human abc2 transporter and uses thereof

Country Status (5)

Country Link
EP (1) EP1210422A2 (en)
JP (1) JP2003509017A (en)
AU (1) AU6677100A (en)
CA (1) CA2383063A1 (en)
WO (1) WO2001014414A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021798A2 (en) * 1999-09-20 2001-03-29 Fox Chase Cancer Center Nucleic acid encoding human abca transporter 2 (abca2) and methods of use thereof
FR2856409B1 (en) * 2003-06-20 2007-08-31 Aventis Pharma Sa METHODS OF DETECTING ALZHEIMER'S DISEASE
US7803538B2 (en) 2003-06-20 2010-09-28 Aventis Pharma Sa Method for detecting Alzheimer's disease
CN110009696A (en) * 2019-04-10 2019-07-12 哈尔滨理工大学 It is demarcated based on ant colony algorithm Optimized BP Neural Network trinocular vision

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002346A2 (en) * 1995-06-30 1997-01-23 Genzyme Corporation Novel human chromosome 16 genes, compositions, methods of making and using same
WO1998048784A2 (en) * 1997-04-28 1998-11-05 The University Of British Columbia Method and composition for modulating amyloidosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002346A2 (en) * 1995-06-30 1997-01-23 Genzyme Corporation Novel human chromosome 16 genes, compositions, methods of making and using same
WO1998048784A2 (en) * 1997-04-28 1998-11-05 The University Of British Columbia Method and composition for modulating amyloidosis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALLIKMETS, R. ET AL.: "Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database", MAMMALIAN GENOME, vol. 6, no. 2, February 1995 (1995-02-01), pages 114 - 117, XP000926159 *
KIKUNO, R. ET AL.: "Prediction of the Coding Sequences of Unidentified Human Genes. XIV. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro", DNA RESEARCH, vol. 6, no. 3, 30 June 1999 (1999-06-30), pages 197 - 205, XP000852618 *
LUCIANI, M.F. ET AL.: "Cloning of Two Novel ABC Transporters Mapping on Human Chromosome 9", GENOMICS, vol. 21, no. 1, 1 May 1994 (1994-05-01), pages 150 - 159, XP000869719 *

Also Published As

Publication number Publication date
CA2383063A1 (en) 2001-03-01
JP2003509017A (en) 2003-03-11
WO2001014414A2 (en) 2001-03-01
EP1210422A2 (en) 2002-06-05
AU6677100A (en) 2001-03-19

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