WO2001013975A3 - Dna-based intramuscular injection system for humans - Google Patents

Dna-based intramuscular injection system for humans Download PDF

Info

Publication number
WO2001013975A3
WO2001013975A3 PCT/US2000/023001 US0023001W WO0113975A3 WO 2001013975 A3 WO2001013975 A3 WO 2001013975A3 US 0023001 W US0023001 W US 0023001W WO 0113975 A3 WO0113975 A3 WO 0113975A3
Authority
WO
WIPO (PCT)
Prior art keywords
dna
injection system
humans
intramuscular injection
pressure
Prior art date
Application number
PCT/US2000/023001
Other languages
French (fr)
Other versions
WO2001013975A2 (en
Inventor
Richard R Stout
Robert A Miller
James M Bonicatto
Original Assignee
Bioject Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioject Inc filed Critical Bioject Inc
Priority to AU70647/00A priority Critical patent/AU7064700A/en
Publication of WO2001013975A2 publication Critical patent/WO2001013975A2/en
Publication of WO2001013975A3 publication Critical patent/WO2001013975A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A method of injecting a DNA-based injectable into a human, using a needle-free injection system (10) is provided. The method includes the steps of first pressuring an injectate (18) within an ampule (12) having a nozzle orifice (16). A peak pressure of approximately 3900-4300 psi adjacent the nozzle, is reached. Then the pressure is immediately reduced to approximately 1200-2100 psi while the injection is continuing. This distributes the DNA-based injectable throughout the muscle tissue and traumatizes the tissue. The pressure is cut-off, normally within 10 ms, to terminate the injection process.
PCT/US2000/023001 1999-08-20 2000-08-18 Dna-based intramuscular injection system for humans WO2001013975A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU70647/00A AU7064700A (en) 1999-08-20 2000-08-18 Intramuscular injection system for injecting dna-based injectables into humans

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37829699A 1999-08-20 1999-08-20
US09/378,296 1999-08-20

Publications (2)

Publication Number Publication Date
WO2001013975A2 WO2001013975A2 (en) 2001-03-01
WO2001013975A3 true WO2001013975A3 (en) 2001-09-07

Family

ID=23492547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/023001 WO2001013975A2 (en) 1999-08-20 2000-08-18 Dna-based intramuscular injection system for humans

Country Status (2)

Country Link
AU (1) AU7064700A (en)
WO (1) WO2001013975A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43824E1 (en) 2001-01-11 2012-11-20 Powder Pharmaceuticals Inc. Needleless syringe
US9044546B2 (en) 2007-05-04 2015-06-02 Powder Pharmaceuticals Incorporated Particle cassettes and processes therefor

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE501751T1 (en) 2000-01-07 2011-04-15 Valeritas Inc INJECTION DEVICE
EP1339442A4 (en) 2000-11-30 2006-12-27 Biovalve Technologies Inc Injection systems
US6607510B2 (en) 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
WO2004041331A1 (en) * 2002-11-01 2004-05-21 Antares Pharma, Inc. Administration of insulin by jet injection
HUE025052T2 (en) 2004-03-08 2016-01-28 Ichor Medical Systems Inc Improved apparatus for electrically mediated delivery of therapeutic agents
US7717874B2 (en) 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
WO2005117959A2 (en) * 2004-06-04 2005-12-15 Merial Limited NEEDLE-FREE ADMINISTRATION OF FeLV BVACCINES
DE102008063040A1 (en) 2008-12-23 2010-06-24 Mt Derm Gmbh Hand-held tattooing device for bringing e.g. medical active ingredient into e.g. human skin, has drives that are coupled to cutting blade for shifting blade in multiple cutting positions along cutting path into basic positions
US9669085B2 (en) 2011-06-01 2017-06-06 Merial Inc. Needle-free administration of PRRSV vaccines
WO2017172838A1 (en) 2016-03-28 2017-10-05 Ichor Medical Systems, Inc. Method and apparatus for delivery of therapeutic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399163A (en) * 1992-07-24 1995-03-21 Bioject Inc. Needleless hypodermic injection methods and device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399163A (en) * 1992-07-24 1995-03-21 Bioject Inc. Needleless hypodermic injection methods and device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FURTH P.A. ET AL.: "Gene transfer into somatic tissues by Jet injection", ANALYTICAL CHEMISTRY, vol. 205, 1992, pages 365 - 368, XP002937756 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43824E1 (en) 2001-01-11 2012-11-20 Powder Pharmaceuticals Inc. Needleless syringe
US9044546B2 (en) 2007-05-04 2015-06-02 Powder Pharmaceuticals Incorporated Particle cassettes and processes therefor
US9358338B2 (en) 2007-05-04 2016-06-07 Powder Pharmaceuticals Incorporated Particle cassettes and processes therefor

Also Published As

Publication number Publication date
WO2001013975A2 (en) 2001-03-01
AU7064700A (en) 2001-03-19

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