WO2001011937A3 - Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines - Google Patents

Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines Download PDF

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Publication number
WO2001011937A3
WO2001011937A3 PCT/US2000/022818 US0022818W WO0111937A3 WO 2001011937 A3 WO2001011937 A3 WO 2001011937A3 US 0022818 W US0022818 W US 0022818W WO 0111937 A3 WO0111937 A3 WO 0111937A3
Authority
WO
WIPO (PCT)
Prior art keywords
colostrinin
analogs
inducing cytokines
constituent peptides
constituent
Prior art date
Application number
PCT/US2000/022818
Other languages
French (fr)
Other versions
WO2001011937A2 (en
Inventor
G John Stanton
Thomas K Hughes Jr
Istvan Boldogh
Jerzy Georgiades
Original Assignee
Univ Texas
Regen Therapeutics Plc
G John Stanton
Thomas K Hughes Jr
Istvan Boldogh
Jerzy Georgiades
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Regen Therapeutics Plc, G John Stanton, Thomas K Hughes Jr, Istvan Boldogh, Jerzy Georgiades filed Critical Univ Texas
Priority to EP00957601A priority Critical patent/EP1224217A4/en
Priority to AU69197/00A priority patent/AU6919700A/en
Publication of WO2001011937A2 publication Critical patent/WO2001011937A2/en
Publication of WO2001011937A3 publication Critical patent/WO2001011937A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention discloses a use of colostrinin, a constituent peptide thereof, and/or an analog thereof as an immunological regulator and as a blood cell regulator in animals including humans.
PCT/US2000/022818 1999-08-17 2000-08-17 Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines WO2001011937A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00957601A EP1224217A4 (en) 1999-08-17 2000-08-17 Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines
AU69197/00A AU6919700A (en) 1999-08-17 2000-08-17 Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14931199P 1999-08-17 1999-08-17
US60/149,311 1999-08-17

Publications (2)

Publication Number Publication Date
WO2001011937A2 WO2001011937A2 (en) 2001-02-22
WO2001011937A3 true WO2001011937A3 (en) 2001-09-07

Family

ID=22529700

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/022818 WO2001011937A2 (en) 1999-08-17 2000-08-17 Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines

Country Status (3)

Country Link
EP (1) EP1224217A4 (en)
AU (1) AU6919700A (en)
WO (1) WO2001011937A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119064B2 (en) 1999-08-17 2006-10-10 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules
US6852685B1 (en) 1999-08-17 2005-02-08 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof to promote neuronal cell differentiation
US6500798B1 (en) 1999-08-17 2002-12-31 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof, as oxidative stress regulators
US6903068B1 (en) 1999-08-17 2005-06-07 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines
WO2002013849A1 (en) * 2000-08-17 2002-02-21 The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines
JP4476934B2 (en) * 2003-04-14 2010-06-09 明治乳業株式会社 Novel peptide and immunostimulant, functional food and method for producing functional food
FR2945537B1 (en) * 2009-05-13 2012-09-07 Agronomique Inst Nat Rech COMPOUNDS INCREASING THE SECRETION OF AT LEAST ONE GASTROINTESTINAL MUCIN
CN103185800B (en) * 2011-12-30 2015-04-08 深圳市亚辉龙生物科技有限公司 Reagent device for detecting anti-cyclic critrullinated polypeptide antibody and method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL185442B1 (en) * 1996-10-03 2003-05-30 Georgiades Biotech Ltd Pharmaceutic agent exhibiting immunoregulating and psychotropic properties, therapeutic form thereof and method of treating diseases of immunological and physical background
GB9912852D0 (en) * 1999-06-02 1999-08-04 Regen Therapeutics Plc Peptides

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
INGLOT ET AL.: "Colostrinine: A proline-rich polypeptide from ovine colostrum is a modest cytokine inducer in human leukocytes", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol. 44, August 1996 (1996-08-01), pages 215 - 224, XP002938306 *
INGLOT ET AL.: "Tumor-associated antigens are cytokine inducers and hyporeactivity factors to the immune system", BIOTHERAPY, vol. 11, no. 1, 1998, pages 27 - 37, XP002938309 *
JANUSZ ET AL.: "Chemical and physical characterization of a proline-rich polypeptide from sheep colostrum", BIOCHEM. J., vol. 199, no. 1, 1981, pages 9 - 15, XP002938312 *
JANUSZ ET AL.: "Isolation and characterization of a proline-rich polypeptide from ovine colostrum", FEBS LETTERS, vol. 49, no. 2, December 1974 (1974-12-01), pages 276 - 279, XP002938311 *
JANUSZ ET AL.: "Proline-rich polypeptide (PRP)-an immunomodulatory peptide from ovine colostrum", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol. 41, no. 5-6, 1993, pages 275 - 279, XP002938308 *
POPIK ET AL.: "Colostrinin, a polypeptide isolated from early milk, facilitates learning and memory in rats", PHARMACOL. BIOCHEM. BEHAV., vol. 64, no. 1, September 1999 (1999-09-01), pages 183 - 189, XP002938310 *
See also references of EP1224217A4 *
ZIMECKI M. ET AL.: "Effect of a proline-rich polypeptide (PRP) on the development of hemolytic anemia and survival of New Zealand black (NZB) mice", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol. 39, no. 5-6, 1991, pages 461 - 467, XP002938307 *

Also Published As

Publication number Publication date
EP1224217A4 (en) 2006-05-24
EP1224217A2 (en) 2002-07-24
AU6919700A (en) 2001-03-13
WO2001011937A2 (en) 2001-02-22

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