WO2001010422A3 - Use of hepoxilins or hepoxilin analogs as antidiabetics, antiinframmatory agents - Google Patents

Use of hepoxilins or hepoxilin analogs as antidiabetics, antiinframmatory agents Download PDF

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Publication number
WO2001010422A3
WO2001010422A3 PCT/CA2000/000896 CA0000896W WO0110422A3 WO 2001010422 A3 WO2001010422 A3 WO 2001010422A3 CA 0000896 W CA0000896 W CA 0000896W WO 0110422 A3 WO0110422 A3 WO 0110422A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepoxilins
antiinframmatory
antidiabetics
agents
hepoxilin analogs
Prior art date
Application number
PCT/CA2000/000896
Other languages
French (fr)
Other versions
WO2001010422A2 (en
WO2001010422A9 (en
Inventor
Cecil R Pace-Asciak
Original Assignee
Cecil R Pace-Asciak
Hsc Res Dev Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cecil R Pace-Asciak, Hsc Res Dev Lp filed Critical Cecil R Pace-Asciak
Priority to AU65508/00A priority Critical patent/AU6550800A/en
Priority to CA2393904A priority patent/CA2393904C/en
Priority to US10/048,863 priority patent/US6673785B1/en
Priority to EP00952812A priority patent/EP1207887A2/en
Publication of WO2001010422A2 publication Critical patent/WO2001010422A2/en
Publication of WO2001010422A3 publication Critical patent/WO2001010422A3/en
Publication of WO2001010422A9 publication Critical patent/WO2001010422A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to the use of native hepoxilins and of hepoxilin analogs for the regulation of insulin secretion and to the use of hepoxilin analogs as anti-inflammatory, anti-diabetic and anti-thrombotic compounds.
PCT/CA2000/000896 1999-08-04 2000-08-03 Use of hepoxilins or hepoxilin analogs as antidiabetics, antiinframmatory agents WO2001010422A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU65508/00A AU6550800A (en) 1999-08-04 2000-08-03 Hepoxilin analogs
CA2393904A CA2393904C (en) 1999-08-04 2000-08-03 Hepoxilin analogs
US10/048,863 US6673785B1 (en) 1999-08-04 2000-08-03 Use of hepoxilins or hepoxilin analogs as antidiabetics, antiinflammatory agents
EP00952812A EP1207887A2 (en) 1999-08-04 2000-08-03 Use of hepoxilins or hepoxilin analogs as antidiabetic, antiinflammatory agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14714399P 1999-08-04 1999-08-04
US60/147,143 1999-08-04
US20830400P 2000-06-01 2000-06-01
US60/208,304 2000-06-01

Publications (3)

Publication Number Publication Date
WO2001010422A2 WO2001010422A2 (en) 2001-02-15
WO2001010422A3 true WO2001010422A3 (en) 2001-08-23
WO2001010422A9 WO2001010422A9 (en) 2002-08-29

Family

ID=26844634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000896 WO2001010422A2 (en) 1999-08-04 2000-08-03 Use of hepoxilins or hepoxilin analogs as antidiabetics, antiinframmatory agents

Country Status (4)

Country Link
EP (1) EP1207887A2 (en)
AU (1) AU6550800A (en)
CA (1) CA2393904C (en)
WO (1) WO2001010422A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2427774C (en) * 2000-11-09 2013-01-15 The Hospital For Sick Children Inhibitors of thromboxane formation and action
EP1509229B1 (en) 2002-05-28 2009-09-23 Pace- Asciak, Cecil R. Compositions comprising hepoxilin analogs and their use in the treatment of cancer
US20040265323A1 (en) * 2003-05-16 2004-12-30 Mccormick Beth A. Compositions comprising pathogen elicited epithelial chemoattractant (eicosanoid hepoxilin A3), inhibitors thereof and methods of use thereof
WO2006106438A2 (en) * 2005-01-11 2006-10-12 Evolva Sa Modulators of ppar activity
WO2007118335A1 (en) 2006-04-19 2007-10-25 Evolva S.A. Hepoxilin analog enantiomers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022848A1 (en) * 1993-03-29 1994-10-13 Pace Asciak Cecil R Hepoxilin analogs useful as anti-inflammatory agents
WO2000007589A1 (en) * 1998-08-07 2000-02-17 Uhtaek Oh Use of lipoxygenase metabolite of arachidonic acid and its derivatives in capsaicin-channel agonist

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022848A1 (en) * 1993-03-29 1994-10-13 Pace Asciak Cecil R Hepoxilin analogs useful as anti-inflammatory agents
US5616607A (en) * 1993-03-29 1997-04-01 Hsc Research And Development Limited Partnership Hepoxilin analogs
WO2000007589A1 (en) * 1998-08-07 2000-02-17 Uhtaek Oh Use of lipoxygenase metabolite of arachidonic acid and its derivatives in capsaicin-channel agonist

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANTON R ET AL: "OCCURRENCE OF HEPOXILINS AND TRIOXILINS IN PSORIATIC LESIONS", JOURNAL OF INVESTIGATIVE DERMATOLOGY,NEW YORK, NY,US, vol. 110, no. 4, April 1998 (1998-04-01), pages 303 - 310, XP000961695, ISSN: 0022-202X *
LANEUVILLE O ET AL: "HEPOXILIN A3 INCREASE VASCULAR PERMEABILITY IN THE RAT SKIN", EICOSANOIDS,SPRINGER INTERNATIONAL, BERLIN,,DE, vol. 4, no. 2, 1991, pages 95 - 97, XP000961744, ISSN: 0941-3464 *
PACE-ASCIAK C R: "HEPOXILINS", GENERAL PHARMACOLOGY,PERGAMON PRESS, OXFORD,GB, vol. 24, no. 4, July 1993 (1993-07-01), pages 805 - 810, XP000961728, ISSN: 0306-3623 *
PETER M. DEMIN ET AL: "Synthesis of Racemic 11,12-Cyclopropyl Analogs of Hepoxilins A3 and B3", TETRAHEDRON LETTERS, vol. 34, no. 27, 1993, pages 4305 - 4308, XP000960341 *
WANG M M ET AL: "STEREOSELECTIVE ACTIONS OF HEPOXILINS A3 AND B3 AND THEIR CYCLOPROPANE ANALOGS ( HXDELTAA3 AND HXDELTAB3) ON BRADYKININ AND PAF-EVOKED POTENTIATION OF VASCULAR LEAKAGE IN RAT SKIN", GENERAL PHARMACOLOGY,PERGAMON PRESS, OXFORD,GB, vol. 33, no. 5, November 1999 (1999-11-01), pages 377 - 382, XP000961664, ISSN: 0306-3623 *

Also Published As

Publication number Publication date
CA2393904C (en) 2012-10-16
EP1207887A2 (en) 2002-05-29
WO2001010422A2 (en) 2001-02-15
WO2001010422A9 (en) 2002-08-29
CA2393904A1 (en) 2001-02-15
AU6550800A (en) 2001-03-05

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