WO2001007625A3 - Ehrlichia canis genes and vaccines - Google Patents

Ehrlichia canis genes and vaccines Download PDF

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Publication number
WO2001007625A3
WO2001007625A3 PCT/US2000/019763 US0019763W WO0107625A3 WO 2001007625 A3 WO2001007625 A3 WO 2001007625A3 US 0019763 W US0019763 W US 0019763W WO 0107625 A3 WO0107625 A3 WO 0107625A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
vaccines
ehrlichia canis
proteins
homolog
Prior art date
Application number
PCT/US2000/019763
Other languages
French (fr)
Other versions
WO2001007625A2 (en
Inventor
Yung-Fu Chang
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Priority to JP2001512891A priority Critical patent/JP2003505087A/en
Priority to IL14773300A priority patent/IL147733A0/en
Priority to BR0012556-3A priority patent/BR0012556A/en
Priority to AU62257/00A priority patent/AU772946B2/en
Priority to CZ2002601A priority patent/CZ2002601A3/en
Priority to EP00948815A priority patent/EP1210438A2/en
Priority to MXPA02000748A priority patent/MXPA02000748A/en
Priority to CA002375650A priority patent/CA2375650A1/en
Publication of WO2001007625A2 publication Critical patent/WO2001007625A2/en
Publication of WO2001007625A3 publication Critical patent/WO2001007625A3/en
Priority to HK03101577.6A priority patent/HK1050708A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/29—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Richettsiales (O)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention provides the sequence of 5,300 nucleotides from the E. canis genome. There are four proteins, ProA, ProB, ORF, and a cytochrome oxidase homolog, as well as a partial lipoprotein signal peptidase homolog at the carboxy terminus, coded for in this cloned fragment. The antigenic properties of these proteins allow them to be used to create a vaccine. An embodiment of this invention includes the creation of a DNA vaccine, a recombinant vaccine, and a T cell epitope vaccine.
PCT/US2000/019763 1999-07-21 2000-07-20 Ehrlichia canis genes and vaccines WO2001007625A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2001512891A JP2003505087A (en) 1999-07-21 2000-07-20 Genes and vaccines for Ehrlichiacanis
IL14773300A IL147733A0 (en) 1999-07-21 2000-07-20 Ehrlichia canis genes and vaccines
BR0012556-3A BR0012556A (en) 1999-07-21 2000-07-20 Ehrlichia canis genes and vaccines
AU62257/00A AU772946B2 (en) 1999-07-21 2000-07-20 Ehrlichia canis genes and vaccines
CZ2002601A CZ2002601A3 (en) 1999-07-21 2000-07-20 Erlichia canis genes and vaccines
EP00948815A EP1210438A2 (en) 1999-07-21 2000-07-20 Ehrlichia canis genes and vaccines
MXPA02000748A MXPA02000748A (en) 1999-07-21 2000-07-20 Ehrlichia canis genes and vaccines.
CA002375650A CA2375650A1 (en) 1999-07-21 2000-07-20 Ehrlichia canis genes and vaccines
HK03101577.6A HK1050708A1 (en) 1999-07-21 2003-03-03 Ehrlichia canis genes and vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35832299A 1999-07-21 1999-07-21
US09/358,322 1999-07-21

Publications (2)

Publication Number Publication Date
WO2001007625A2 WO2001007625A2 (en) 2001-02-01
WO2001007625A3 true WO2001007625A3 (en) 2001-10-11

Family

ID=23409210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019763 WO2001007625A2 (en) 1999-07-21 2000-07-20 Ehrlichia canis genes and vaccines

Country Status (12)

Country Link
EP (1) EP1210438A2 (en)
JP (1) JP2003505087A (en)
CN (1) CN1367832A (en)
AU (1) AU772946B2 (en)
BR (1) BR0012556A (en)
CA (1) CA2375650A1 (en)
CZ (1) CZ2002601A3 (en)
HK (1) HK1050708A1 (en)
IL (1) IL147733A0 (en)
MX (1) MXPA02000748A (en)
WO (1) WO2001007625A2 (en)
ZA (1) ZA200200035B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7335754B2 (en) 1999-07-21 2008-02-26 Cornell Research Foundation, Inc. Ehrlichia canis genes and vaccines
CA2505367A1 (en) 2002-11-07 2004-05-27 Abbott Laboratories Prosthesis having varied concentration of beneficial agent
BRPI0411127A (en) * 2003-06-10 2006-05-23 Univ Melbourne composition of matter for immune response modulation in a subject antigen subject and its modulation method, antigen presenting cell production process and method of treatment and / or prophylaxis of disease or condition associated with the presence of target antigen of interest
KR101892182B1 (en) * 2009-11-20 2018-08-24 아박시스, 인크. Peptides, devices, and methods for the detection of ehrlichia antibodies
KR102106762B1 (en) 2012-10-11 2020-05-06 아박시스, 인크. Peptides, devices, and methods for the detection of ehrlichia antibodies
US9442112B2 (en) 2014-04-04 2016-09-13 Abaxis, Inc. Compositions and methods for identifying Ehrlichia species

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016554A1 (en) * 1996-10-17 1998-04-23 University Of Florida Nucleic acid vaccines against rickettsial diseases and methods of use
WO1998042743A1 (en) * 1997-03-24 1998-10-01 Merial Canine ehrlichiosis immunogenic and diagnostic compositions and methods
WO1999013720A1 (en) * 1997-09-19 1999-03-25 The Ohio State Research Foundation Outer membrane protein of ehrlichia canis and ehrlichia chaffeensis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207169B1 (en) * 1997-03-21 2001-03-27 Corixa Corporation Compounds and methods for the diagnosis and treatment of Ehrlichia infection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016554A1 (en) * 1996-10-17 1998-04-23 University Of Florida Nucleic acid vaccines against rickettsial diseases and methods of use
WO1998042743A1 (en) * 1997-03-24 1998-10-01 Merial Canine ehrlichiosis immunogenic and diagnostic compositions and methods
WO1999013720A1 (en) * 1997-09-19 1999-03-25 The Ohio State Research Foundation Outer membrane protein of ehrlichia canis and ehrlichia chaffeensis

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ANDERSSON S G E ET AL., NATURE, vol. 396, 1998, pages 133 - 140 *
DATABASE EMPRO1 EMBL Heidelberg, Germany; 1 May 1997 (1997-05-01), YAMANE K ET AL.: "The 25 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes", XP002163810 *
DATABASE EMPRO1 EMBL Heidelberg, Germany; 21 November 1998 (1998-11-21), ANDERSSON S G E ET AL.: "The genome of sequence of Rickettsia prowazekii and the origin of mitochondria", XP002163811 *
DATABASE EMPRO2 EMBL Heidelberg, Germany; 19 June 1997 (1997-06-19), FREIBERG C ET AL., XP002163809 *
DATABASE EMPRO2 EMBL Heidelberg, Germany; 24 January 1996 (1996-01-24), SPRINGER A L ET AL., XP002163808 *
DATABASE PIR2 EMBL, Heidelberg, Germany; 16 August 1996 (1996-08-16), XP002154411 *
FREIBERG C ET AL: "MOLECULAR BASIS OF SYMBIOSIS BETWEEN RHIZOBIUM AND LEGUMES", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 387, no. 6631, 22 May 1997 (1997-05-22), pages 394 - 401, XP002047854, ISSN: 0028-0836 *
SPRINGER AMY L ET AL: "Characterization and nucleotide sequence of pqqE and pqqF in Methylobacterium extorquens AM1.", JOURNAL OF BACTERIOLOGY, vol. 178, no. 7, 1996, pages 2154 - 2157, XP000990643, ISSN: 0021-9193 *
WAGHELA S D ET AL.: "A cloned DNA probe identifies Cowdria ruminantium in Amblyomma variegatum ticks", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 29, no. 11, 1991, pages 2571 - 2577, XP000960522, ISSN: 0095-1137 *
YAMANE K ET AL.: "Homologue of multidrug resistance protein B", MICROBIOLOGY, vol. 142, 1996, pages 3047 - 3056 *

Also Published As

Publication number Publication date
HK1050708A1 (en) 2003-07-04
BR0012556A (en) 2002-07-02
AU6225700A (en) 2001-02-13
MXPA02000748A (en) 2003-07-14
WO2001007625A2 (en) 2001-02-01
JP2003505087A (en) 2003-02-12
CZ2002601A3 (en) 2003-04-16
CN1367832A (en) 2002-09-04
IL147733A0 (en) 2002-08-14
CA2375650A1 (en) 2001-02-01
ZA200200035B (en) 2003-10-02
EP1210438A2 (en) 2002-06-05
AU772946B2 (en) 2004-05-13

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