WO2001007027A3 - Pyrimidine derivatives for the treatment of viral diseases - Google Patents
Pyrimidine derivatives for the treatment of viral diseases Download PDFInfo
- Publication number
- WO2001007027A3 WO2001007027A3 PCT/US2000/019650 US0019650W WO0107027A3 WO 2001007027 A3 WO2001007027 A3 WO 2001007027A3 US 0019650 W US0019650 W US 0019650W WO 0107027 A3 WO0107027 A3 WO 0107027A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- virus
- treatment
- preferred
- viral diseases
- pyrimidine derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU61110/00A AU6111000A (en) | 1999-07-22 | 2000-07-19 | Inhibitors of viral helcase |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14519399P | 1999-07-22 | 1999-07-22 | |
US60/145,193 | 1999-07-22 | ||
US15078399P | 1999-08-26 | 1999-08-26 | |
US60/150,783 | 1999-08-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001007027A2 WO2001007027A2 (en) | 2001-02-01 |
WO2001007027A3 true WO2001007027A3 (en) | 2001-08-09 |
Family
ID=26842750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/019650 WO2001007027A2 (en) | 1999-07-22 | 2000-07-19 | Pyrimidine derivatives for the treatment of viral diseases |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU6111000A (en) |
WO (1) | WO2001007027A2 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4186484B2 (en) | 2002-03-12 | 2008-11-26 | 住友化学株式会社 | Pyrimidine compounds and uses thereof |
TWI312272B (en) | 2003-05-12 | 2009-07-21 | Sumitomo Chemical Co | Pyrimidine compound and pests controlling composition containing the same |
JPWO2005019225A1 (en) * | 2003-08-21 | 2007-11-01 | 杏林製薬株式会社 | Method for producing compound having NK1 receptor antagonistic activity and production intermediate thereof |
EP2206715A1 (en) | 2004-02-24 | 2010-07-14 | Japan Tobacco, Inc. | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor |
US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
WO2007047146A2 (en) * | 2005-10-11 | 2007-04-26 | Intermune, Inc. | Inhibitors of viral replication |
US8017612B2 (en) | 2006-04-18 | 2011-09-13 | Japan Tobacco Inc. | Piperazine compound and use thereof as a HCV polymerase inhibitor |
AU2007323335A1 (en) * | 2006-11-23 | 2008-05-29 | Novartis Ag | Pyrimidines and their use as CXCR2 receptor antagonists |
WO2009032668A2 (en) | 2007-08-28 | 2009-03-12 | Irm Llc | 2 -biphenylamino-4 -aminopyrimidine derivatives as kinase inhibitors |
PE20091236A1 (en) | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | PYRIMIDINE DERIVATIVES AS IMMUNOMODULATORS OF TLR7 |
US8445505B2 (en) | 2008-06-25 | 2013-05-21 | Irm Llc | Pyrimidine derivatives as kinase inhibitors |
PE20100087A1 (en) | 2008-06-25 | 2010-02-08 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS |
EP2326627A1 (en) * | 2008-08-20 | 2011-06-01 | Schering Corporation | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
TW201020245A (en) | 2008-08-20 | 2010-06-01 | Schering Corp | Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
CA2734488A1 (en) | 2008-08-20 | 2010-02-25 | Southern Research Institute | Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
AU2009282574B2 (en) | 2008-08-20 | 2014-08-21 | Merck Sharp & Dohme Corp. | Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
MX2011012337A (en) | 2009-05-21 | 2011-12-08 | Dainippon Sumitomo Pharma Co | Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases. |
GB0908772D0 (en) | 2009-05-21 | 2009-07-01 | Astrazeneca Ab | New salts 756 |
EA023350B1 (en) * | 2009-10-16 | 2016-05-31 | Мелинта Терапьютикс, Инк. | Antimicrobial compounds, methods of making and using the same |
WO2012060847A1 (en) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
EP2651937B8 (en) | 2010-12-16 | 2016-07-13 | Sumitomo Dainippon Pharma Co., Ltd. | Imidazo[4,5-c]quinolin-1-yl derivative useful in therapy |
WO2012113920A1 (en) | 2011-02-24 | 2012-08-30 | Katholieke Universiteit Leuven | Arylsulfone derivatives with activity against human betaherpesviruses |
JP6184423B2 (en) | 2012-05-18 | 2017-08-23 | 大日本住友製薬株式会社 | Carboxylic acid compound |
CN106496190A (en) * | 2016-10-18 | 2017-03-15 | 北京瑞济善健康科技有限公司 | New type NS 5B inhibitor and application thereof |
CN107951887A (en) * | 2016-10-18 | 2018-04-24 | 李文超 | A kind of antiviral drugs |
CN107954983A (en) * | 2016-10-18 | 2018-04-24 | 陈利华 | Pyrimidinones and application thereof |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4308272A (en) * | 1980-10-03 | 1981-12-29 | The Upjohn Company | Process for treating hypertension |
GB2158068A (en) * | 1984-04-26 | 1985-11-06 | Aston Molecules Ltd | Pyrimidine derivative solvate compounds |
US5256668A (en) * | 1993-03-17 | 1993-10-26 | American Home Products Corporation | Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus |
WO1996010565A1 (en) * | 1994-10-04 | 1996-04-11 | Istituto Superiore Di Sanita' | Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them |
WO1996041634A2 (en) * | 1995-06-13 | 1996-12-27 | Sardinian Antiviral Research Consortium - Sarc S.C.R.L. | Use of a non-nucleoside reverse transcriptase inhibitor in association with nucleoside inhibitors for the treatment of hiv infection |
WO1997006804A1 (en) * | 1995-08-19 | 1997-02-27 | Glaxo Group Limited | 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis c |
WO2000003998A1 (en) * | 1998-07-17 | 2000-01-27 | Novirio Pharmaceuticals Limited | Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them |
WO2000013708A1 (en) * | 1998-09-04 | 2000-03-16 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
-
2000
- 2000-07-19 AU AU61110/00A patent/AU6111000A/en not_active Abandoned
- 2000-07-19 WO PCT/US2000/019650 patent/WO2001007027A2/en active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4308272A (en) * | 1980-10-03 | 1981-12-29 | The Upjohn Company | Process for treating hypertension |
GB2158068A (en) * | 1984-04-26 | 1985-11-06 | Aston Molecules Ltd | Pyrimidine derivative solvate compounds |
US5256668A (en) * | 1993-03-17 | 1993-10-26 | American Home Products Corporation | Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus |
WO1996010565A1 (en) * | 1994-10-04 | 1996-04-11 | Istituto Superiore Di Sanita' | Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them |
WO1996041634A2 (en) * | 1995-06-13 | 1996-12-27 | Sardinian Antiviral Research Consortium - Sarc S.C.R.L. | Use of a non-nucleoside reverse transcriptase inhibitor in association with nucleoside inhibitors for the treatment of hiv infection |
WO1997006804A1 (en) * | 1995-08-19 | 1997-02-27 | Glaxo Group Limited | 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis c |
WO2000003998A1 (en) * | 1998-07-17 | 2000-01-27 | Novirio Pharmaceuticals Limited | Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them |
WO2000013708A1 (en) * | 1998-09-04 | 2000-03-16 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
Non-Patent Citations (6)
Title |
---|
ANTONELLO MAI ET AL: "5-ALKYL-2-ALKYLTHIO-6-(2,6-DIHALOPHENYLMETHYL)-3,4-DIHYDROPYRIMIDIN-4 (3H)-ONES", JOURNAL OF MEDICINAL CHEMISTRY,AMERICAN CHEMICAL SOCIETY. WASHINGTON,US, vol. 42, 25 February 1999 (1999-02-25), pages 619 - 627, XP002123507, ISSN: 0022-2623 * |
DALE A. STRINGFELLOW ET AL: "5-HALO-6- PHENYL PYRIMIDINES: A NEW SERIES OF INTERFERON- INDUCING AGENTS", INTERFERON: PROP. CLIN. USES, 1980, pages 315 - 326, XP000979815 * |
LI, L. H. ET AL: "Effect of mouse hepatitis virus infection on combination therapy of P388 leukemia with cyclophosphamide and pyrimidinones", LAB. ANIM. SCI. (1987), 37(1), 41-4, XP002159448 * |
MAI A ET AL: "SYNTHESIS AND ANTI-HIV-1 ACTIVITY OF THIO ANALOGUES OF DIHYDROALKOXYBENZYLOXOPYRIMIDINES", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 38, no. 17, 1995, pages 3258 - 3263, XP000578131, ISSN: 0022-2623 * |
RENIS, H. E. ET AL: "Protection of mice from herpes simplex virus infection by 5-halo-6-aryl-isocytosines", CURR. CHEMOTHER. INFECT. DIS., PROC. INT. CONGR. CHEMOTHER., 11TH (1980), MEETING DATE 1979, VOLUME 2, 1411-13. EDITOR(S): NELSON, JOHN D.;GRASSI, CARLO. PUBLISHER: AM. SOC. MICROBIOL., WASHINGTON, D. C., XP000981311 * |
WEED S D ET AL: "ANTI VIRAL PROPERTIES OF 6 ARYL PYRIMIDINES", CURR. CHEMOTHER. INFECT. DIS., 1980, pages P1408 - 1409, XP000981310 * |
Also Published As
Publication number | Publication date |
---|---|
AU6111000A (en) | 2001-02-13 |
WO2001007027A2 (en) | 2001-02-01 |
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