WO2000062707A2 - Use of osseo-promotive membranes in orthopaedics - Google Patents
Use of osseo-promotive membranes in orthopaedics Download PDFInfo
- Publication number
- WO2000062707A2 WO2000062707A2 PCT/GB2000/001349 GB0001349W WO0062707A2 WO 2000062707 A2 WO2000062707 A2 WO 2000062707A2 GB 0001349 W GB0001349 W GB 0001349W WO 0062707 A2 WO0062707 A2 WO 0062707A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bone
- membrane
- use according
- layer
- injury
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30742—Bellows or hose-like seals; Sealing membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30462—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements retained or tied with a rope, string, thread, wire or cable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30589—Sealing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30971—Laminates, i.e. layered products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4631—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor the prosthesis being specially adapted for being cemented
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00357—Wound bandages implanted wound fillings or covers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
- A61F2250/0024—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity made from both porous and non-porous parts, e.g. adjacent parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
Definitions
- This invention relates to the use of osseo-promotive membranes in regeneration of bone where the bone has been injured by disease, accident or surgery.
- the present invention provides for use of an occlusive or semi-occlusive membrane in the manufacture of a device for the promotion of bone ingrowth in orthopaedic surgery, wherein a bone injury is sealed by closing said injury with a membrane which is substantially inert to body fluids and is adapted to prevent ingrowth of fibrous tissues into said injury.
- the membrane is a polymer of a fluorinated monomer and may be totally non-porous to body fluids or may be semi-permeable.
- the pore sizes should not exceed 250 microns and, preferably, should not exceed 200 microns.
- a suitable range of pore sizes is from 0.5 micron to 200
- the membrane should be bio-compatible and essentially inert to body fluids.
- Preferred materials are fluorinated olefins, especially perfluorinated olefins, e.g. perfluorinated ethylene and propylene.
- Polytetrafluoroethylene is currently preferred. Where the membrane is semi-permeable, an expanded polytetrafluoroethylene is preferred.
- the membrane is a laminate of at least two layers of material.
- One of the layers may have a pore size which is large enough to be penetrated by soft, fibrous tissue cells, e.g. at a size greater than 250 microns.
- An adjacent layer may be totally occlusive or have much smaller pore openings so that fibrous soft tissue cells cannot penetrate the second layer.
- the membrane whether a single sheet or a laminate, may be up to about 1 to 1.5 mm thick, preferably from about 300 to 1000 microns thick.
- the occlusive or semi-occlusive layer having small particle sizes is positioned adjacent the bone injury so that soft fibrous cells cannot penetrate into the space created and sealed off by the membrane.
- the laminate comprises at least three layers, the layer adjacent the bone injury is occlusive or contains only pore openings having an average size less than 250 microns, preferably less than 200 microns.
- a three-layer laminate in which the control layer has the smaller pore size is preferred, since it is symmetrical and can be used reversibly.
- multi-layer laminates in which the outer layers are of the same or similar larger pore sizes are also advantageous.
- the layers are preferably welded together. While the membranes can be sutured to bone or tissue to seal off the injured site, the inventors have discovered that one effective procedure is to adhesively bond the edges of the membrane around the perimeter of the injury. Suitable adhesives include medical grade cyanoacrylate polymers (commonly known as super glues), and the adhesive material sold under the trade mark "Histoacryl blue" by B. Braun Melsache A.G. is currently preferred.
- Another method of sealing the ends of the membrane is to pass a ligature, such as a loop of metal wire, around the bone and to tighten the loop around the base.
- a ligature such as a loop of metal wire
- Alternative methods of fixing the membrane to the bone include staples or pins. Of course, a combination of these fixing methods may be employed.
- Figure 1 A shows a section through a hip prosthesis inserted in a femur
- Figure IB shows a similar view with a membrane fitted over and sealing the gap between the prosthesis and the hole formed to receive the bone;
- Figure 2A shows a bone which has suffered a severe fracture
- Figure 2B depicts the invasion of soft tissue into the fracture hindering bone
- Figure 2C illustrates bone formation promoted by fitting of a membrane around
- Figure 3A illustrates bone defect caused by surgery to remove a tumour in
- Figure 3B illustrates the use of a membrane to promote bone growth.
- FIG 4A illustrates the situation where an intramedullary rod has been
- Figure 4B illustrates the use of a membrane to prevent fibrous tissue ingrowth.
- hip replacement prosthesis has been inserted into a femur (2) leaving a jimction (3)
- the membranes used in accordance with the present invention may be any membrane used in accordance with the present invention.
- edges of the membrane are preferably
- an adhesive preferably a
- the membrane (11) may be sealed to its self and to the upper and lower portions of the bone to prevent ingress of fibrous tissue material into the fracture site.
- the membrane will confine growth factors present in the bone and other bone-inducible agents or materials such as an altograft or autograft to the defect site and in the vicinity of the healing bone.
- growth factors present in the bone and other bone-inducible agents or materials such as an altograft or autograft to the defect site and in the vicinity of the healing bone.
- FIGs 3A and 3B illustrate the application of the invention to surgical treatment of bone tumour.
- a bone (20) has been cut away to remove the tumour and a replacement implant (21) fitted into the healthy bone.
- the implant (21) having a fixing stem (21a) may be fitted into the healthy bone using a bone cement (22), and the implant may be provided with a surface treatment of hydroxy-apatite, especially to the stem, to promote bonding of the bone to the surface of the implant.
- a blood clot may form or be artificially induced at the junction (23) between the implant and the bone and this area is sealed as shown in Figure 3B by wrapping the area with a membrane (24).
- the membrane (24) is fixed as by gluing to the implant and to the bone to create a space (25) within which bone growth is promoted to bond the healthy bone to the implant.
- the membrane may be sealed around the bone by positioning wires (101) & (102) around the ends of the membrane and tensioning the wires to form seals between the membrane and the bone or implant.
- Figures 4 A and 4B illustrate a similar use of the membranes in accordance with the invention in which an intramedullary rod having an hydroxy apatite coated collar (31) having a fixing stem (31a) is introduced into a damaged bone (30) using a bone cement (32). Again, a blood clot material (33) is formed or induced around the junction between the intramedullary rod and the bone and this area is wrapped with a membrane (34) in accordance with the invention.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00919041A EP1168983A2 (en) | 1999-04-15 | 2000-04-10 | Use of osseo-promotive membranes in orthopaedics |
AU39797/00A AU3979700A (en) | 1999-04-15 | 2000-04-10 | Use of osseo-promotive membranes in orthopaedics |
CA002370358A CA2370358A1 (en) | 1999-04-15 | 2000-04-10 | Use of osseo-promotive membranes in orthopaedics |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9908638.1 | 1999-04-15 | ||
GBGB9908638.1A GB9908638D0 (en) | 1999-04-15 | 1999-04-15 | Use of osseo-promotive membranes in orthopaedics |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000062707A2 true WO2000062707A2 (en) | 2000-10-26 |
WO2000062707A3 WO2000062707A3 (en) | 2001-01-25 |
Family
ID=10851601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2000/001349 WO2000062707A2 (en) | 1999-04-15 | 2000-04-10 | Use of osseo-promotive membranes in orthopaedics |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1168983A2 (en) |
AU (1) | AU3979700A (en) |
CA (1) | CA2370358A1 (en) |
GB (1) | GB9908638D0 (en) |
WO (1) | WO2000062707A2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1340476A1 (en) * | 2002-02-28 | 2003-09-03 | MacroPore Biosurgery, Inc. | Resorbable membrane barrier for governing bone growth |
WO2003043546A3 (en) * | 2001-11-20 | 2003-10-30 | Bionx Implants Oy | Joint prosthesis |
JP2005124463A (en) * | 2003-10-23 | 2005-05-19 | Jms Co Ltd | Culture carrier, culture using the same and method for preparing culture |
US7704520B1 (en) | 2002-09-10 | 2010-04-27 | Mast Biosurgery Ag | Methods of promoting enhanced healing of tissues after cardiac surgery |
US7744915B2 (en) | 2002-07-31 | 2010-06-29 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
US7947300B2 (en) | 2000-03-10 | 2011-05-24 | Mast Biosurgery Ag | Resorbable thin membranes |
US8048444B2 (en) | 2002-07-31 | 2011-11-01 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3953566A (en) | 1970-05-21 | 1976-04-27 | W. L. Gore & Associates, Inc. | Process for producing porous products |
WO1995010990A1 (en) | 1993-10-21 | 1995-04-27 | University College London | Bone implants |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4414675C1 (en) * | 1994-04-27 | 1995-09-28 | Kirsch Axel | Covering device for bone defects and method for their production |
DE69524075T2 (en) * | 1995-02-14 | 2002-09-12 | Gore & Ass | DEVICE FOR PROTECTING JOINT PROSTHESES FROM WEAR PIECES |
DE19520866C2 (en) * | 1995-06-08 | 1998-04-16 | Kirsch Axel | Device for treating a bone recess |
-
1999
- 1999-04-15 GB GBGB9908638.1A patent/GB9908638D0/en not_active Ceased
-
2000
- 2000-04-10 CA CA002370358A patent/CA2370358A1/en not_active Abandoned
- 2000-04-10 AU AU39797/00A patent/AU3979700A/en not_active Abandoned
- 2000-04-10 WO PCT/GB2000/001349 patent/WO2000062707A2/en not_active Application Discontinuation
- 2000-04-10 EP EP00919041A patent/EP1168983A2/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3953566A (en) | 1970-05-21 | 1976-04-27 | W. L. Gore & Associates, Inc. | Process for producing porous products |
US4187390A (en) | 1970-05-21 | 1980-02-05 | W. L. Gore & Associates, Inc. | Porous products and process therefor |
WO1995010990A1 (en) | 1993-10-21 | 1995-04-27 | University College London | Bone implants |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7947300B2 (en) | 2000-03-10 | 2011-05-24 | Mast Biosurgery Ag | Resorbable thin membranes |
US8012502B2 (en) | 2000-03-10 | 2011-09-06 | Mast Biosurgery Ag | Resorbable thin membranes |
US8349795B2 (en) | 2000-03-10 | 2013-01-08 | Mast Biosurgery Ag | Resorbable thin membranes |
WO2003043546A3 (en) * | 2001-11-20 | 2003-10-30 | Bionx Implants Oy | Joint prosthesis |
EP1340476A1 (en) * | 2002-02-28 | 2003-09-03 | MacroPore Biosurgery, Inc. | Resorbable membrane barrier for governing bone growth |
CN100407999C (en) * | 2002-02-28 | 2008-08-06 | 马克罗珀尔生物外科公司 | Method for controlling bone grouth |
US7744915B2 (en) | 2002-07-31 | 2010-06-29 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
US7767222B2 (en) | 2002-07-31 | 2010-08-03 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
US8048444B2 (en) | 2002-07-31 | 2011-11-01 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
US7704520B1 (en) | 2002-09-10 | 2010-04-27 | Mast Biosurgery Ag | Methods of promoting enhanced healing of tissues after cardiac surgery |
JP2005124463A (en) * | 2003-10-23 | 2005-05-19 | Jms Co Ltd | Culture carrier, culture using the same and method for preparing culture |
Also Published As
Publication number | Publication date |
---|---|
EP1168983A2 (en) | 2002-01-09 |
CA2370358A1 (en) | 2000-10-26 |
WO2000062707A3 (en) | 2001-01-25 |
GB9908638D0 (en) | 1999-06-09 |
AU3979700A (en) | 2000-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9724183B2 (en) | Surgical method, kit of parts, and implant | |
US4457028A (en) | Surgical materials suitable for use with bone cements | |
EP0928168B1 (en) | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration | |
KR101027252B1 (en) | Craniofacial implant | |
US9456905B2 (en) | Continuous phase composite for musculoskeletal repair | |
US8652214B2 (en) | Cartilage replacement implant and method for producing a cartilage replacement implant | |
JP5002008B2 (en) | Craniofacial implant | |
US8187336B2 (en) | Device and method for reconstruction of osseous skeletal defects | |
EP0466820B1 (en) | Articles for treating periodontal disease and bone defects | |
KR100959954B1 (en) | A Barrier Membrane For Governing Bone Growth | |
US20090138096A1 (en) | Foot/ankle implant and associated method | |
Jackson et al. | Hydroxyapatite cement: an alternative for craniofacial skeletal contour refinements | |
JPH05253247A (en) | Inner transplanting object for fixing dental prosthesis at jawbone | |
US20110033827A1 (en) | Method of using dental material and composite dental material formed by using hydroxyapatite | |
US20210121293A1 (en) | Soft tissue repair using a porous coated implant | |
JPS59200642A (en) | Bone fixing nail | |
Matras | Fibrin Sealant in Maxillofacial Surgery–Development and Indications–A Review of the Past 12 Years | |
US9861724B2 (en) | Method for fusion of fractured or voided sternum post sternotomy | |
WO2000062707A2 (en) | Use of osseo-promotive membranes in orthopaedics | |
JP4698033B2 (en) | Bone repair device | |
WO1994018910A1 (en) | Orthopaedic reconstruction plate | |
US20220151740A1 (en) | Dental device for ridge preservation and promotion of jaw bone regeneration in an extraction site | |
KR101636988B1 (en) | Pocket type membrane for implant | |
JP2003501201A (en) | Medical membrane that stimulates tissue formation | |
RU2177757C2 (en) | Method for creating overhang of cotyloid cavity roof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
ENP | Entry into the national phase in: |
Ref document number: 2370358 Country of ref document: CA Ref country code: CA Ref document number: 2370358 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000919041 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2000919041 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09958768 Country of ref document: US |
|
NENP | Non-entry into the national phase in: |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2000919041 Country of ref document: EP |