WO2000053759A8 - Expression of human alpha-fetoprotein in mammalian cells - Google Patents

Expression of human alpha-fetoprotein in mammalian cells

Info

Publication number
WO2000053759A8
WO2000053759A8 PCT/US2000/006038 US0006038W WO0053759A8 WO 2000053759 A8 WO2000053759 A8 WO 2000053759A8 US 0006038 W US0006038 W US 0006038W WO 0053759 A8 WO0053759 A8 WO 0053759A8
Authority
WO
WIPO (PCT)
Prior art keywords
fetoprotein
mammalian cells
human alpha
expression
cells
Prior art date
Application number
PCT/US2000/006038
Other languages
French (fr)
Other versions
WO2000053759A1 (en
Inventor
Stace Lindsay
Robert Mulroy
Daniel Semeniuk
Original Assignee
Atlantic Biopharmaceuticals In
Stace Lindsay
Robert Mulroy
Daniel Semeniuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atlantic Biopharmaceuticals In, Stace Lindsay, Robert Mulroy, Daniel Semeniuk filed Critical Atlantic Biopharmaceuticals In
Priority to AU38712/00A priority Critical patent/AU3871200A/en
Priority to CA002365843A priority patent/CA2365843A1/en
Priority to JP2000603380A priority patent/JP2002537838A/en
Priority to IL14505600A priority patent/IL145056A0/en
Priority to EP00917794A priority patent/EP1161533A1/en
Publication of WO2000053759A1 publication Critical patent/WO2000053759A1/en
Publication of WO2000053759A8 publication Critical patent/WO2000053759A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention features a nucleic acid, vector, cells, and processes for expressing recombinant human alpha-fetoprotein (rHuAFP) in cultured mammalian cells.
PCT/US2000/006038 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells WO2000053759A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU38712/00A AU3871200A (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells
CA002365843A CA2365843A1 (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells
JP2000603380A JP2002537838A (en) 1999-03-09 2000-03-08 Expression of human α-fetoprotein in mammalian cells
IL14505600A IL145056A0 (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells
EP00917794A EP1161533A1 (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12366699P 1999-03-09 1999-03-09
US60/123,666 1999-03-09

Publications (2)

Publication Number Publication Date
WO2000053759A1 WO2000053759A1 (en) 2000-09-14
WO2000053759A8 true WO2000053759A8 (en) 2000-11-09

Family

ID=22410086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006038 WO2000053759A1 (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells

Country Status (6)

Country Link
EP (1) EP1161533A1 (en)
JP (1) JP2002537838A (en)
AU (1) AU3871200A (en)
CA (1) CA2365843A1 (en)
IL (1) IL145056A0 (en)
WO (1) WO2000053759A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208576B2 (en) * 1999-01-06 2007-04-24 Merrimack Pharmaceuticals, Inc. Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof
EP1194536B1 (en) * 1999-07-12 2008-12-24 Universite Libre De Bruxelles Non-human genetically modified mammal lacking the alpha-fetoprotein
US7022892B1 (en) 1999-07-12 2006-04-04 Universite Libre De Bruxelles Non-human genetically modified mammal lacking the alpha-fetoprotein
EA011606B1 (en) * 2004-07-14 2009-04-28 Эдуард Борисович Татулов Methods of producing recombinant alpha-fetoprotein and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0755446B1 (en) * 1994-04-25 2006-09-13 Genentech, Inc. Cardiotrophin and uses therefor

Also Published As

Publication number Publication date
WO2000053759A1 (en) 2000-09-14
AU3871200A (en) 2000-09-28
EP1161533A1 (en) 2001-12-12
IL145056A0 (en) 2002-06-30
CA2365843A1 (en) 2000-09-14
JP2002537838A (en) 2002-11-12

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