WO2000047612A3 - Techniques de criblage a base de structure permettant de decouvrir un medicament - Google Patents
Techniques de criblage a base de structure permettant de decouvrir un medicament Download PDFInfo
- Publication number
- WO2000047612A3 WO2000047612A3 PCT/US2000/003665 US0003665W WO0047612A3 WO 2000047612 A3 WO2000047612 A3 WO 2000047612A3 US 0003665 W US0003665 W US 0003665W WO 0047612 A3 WO0047612 A3 WO 0047612A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- naturally occurring
- cell surface
- drug discovery
- surface receptor
- screening techniques
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/746—Erythropoetin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000598528A JP2002540384A (ja) | 1999-02-11 | 2000-02-11 | 構造ベースでの薬効物質スクリーニング法 |
AU28808/00A AU2880800A (en) | 1999-02-11 | 2000-02-11 | Structure-based screening techniques for drug discovery |
CA002362541A CA2362541A1 (fr) | 1999-02-11 | 2000-02-11 | Techniques de criblage a base de structure permettant de decouvrir un medicament |
EP00907284A EP1153295A2 (fr) | 1999-02-11 | 2000-02-11 | Techniques de criblage a base de structure permettant de decouvrir un medicament |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12000999P | 1999-02-11 | 1999-02-11 | |
US60/120,009 | 1999-02-11 | ||
US13167499P | 1999-04-29 | 1999-04-29 | |
US60/131,674 | 1999-04-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000047612A2 WO2000047612A2 (fr) | 2000-08-17 |
WO2000047612A3 true WO2000047612A3 (fr) | 2000-12-14 |
Family
ID=26817948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/003665 WO2000047612A2 (fr) | 1999-02-11 | 2000-02-11 | Techniques de criblage a base de structure permettant de decouvrir un medicament |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1153295A2 (fr) |
JP (1) | JP2002540384A (fr) |
AU (1) | AU2880800A (fr) |
CA (1) | CA2362541A1 (fr) |
WO (1) | WO2000047612A2 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8457903B1 (en) | 1999-01-19 | 2013-06-04 | Codexis Mayflower Holdings, Llc | Method and/or apparatus for determining codons |
US7873477B1 (en) | 2001-08-21 | 2011-01-18 | Codexis Mayflower Holdings, Llc | Method and system using systematically varied data libraries |
US7702464B1 (en) | 2001-08-21 | 2010-04-20 | Maxygen, Inc. | Method and apparatus for codon determining |
AU2003284260B2 (en) * | 2002-10-11 | 2010-06-03 | Zymogenetics, Inc. | Production of homotrimeric fusion proteins |
AU2004270774A1 (en) * | 2003-09-05 | 2005-03-17 | National Research Council Of Canada | Coiled-coil fusion proteins comprising cell receptor domains |
US7786261B2 (en) | 2004-09-02 | 2010-08-31 | National Research Council Of Canada | Coiled-coil fusion proteins comprising cell receptor domains |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0638787A (ja) * | 1992-03-04 | 1994-02-15 | Snow Brand Milk Prod Co Ltd | 可溶性エリスロポエチン受容体蛋白質、およびそのアミノ酸配列をコードする遺伝子 |
US5292654A (en) * | 1990-12-13 | 1994-03-08 | Whitehead Institute For Biomedical Research | Mutant EPO receptor and uses therefor |
WO1994029458A1 (fr) * | 1993-06-07 | 1994-12-22 | Amgen Inc. | Molecules receptrices hybrides |
EP0742438A2 (fr) * | 1995-05-10 | 1996-11-13 | Bayer Corporation | Triage de librairie peptidiques combinatoires pour sélection de ligand peptidique utile à la purification d'affinité des protéines cibles |
WO1998047089A1 (fr) * | 1997-04-11 | 1998-10-22 | California Institute Of Technology | Dispositif et methode permettant une mise au point informatisee de proteines |
-
2000
- 2000-02-11 AU AU28808/00A patent/AU2880800A/en not_active Abandoned
- 2000-02-11 CA CA002362541A patent/CA2362541A1/fr not_active Abandoned
- 2000-02-11 WO PCT/US2000/003665 patent/WO2000047612A2/fr not_active Application Discontinuation
- 2000-02-11 JP JP2000598528A patent/JP2002540384A/ja active Pending
- 2000-02-11 EP EP00907284A patent/EP1153295A2/fr not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292654A (en) * | 1990-12-13 | 1994-03-08 | Whitehead Institute For Biomedical Research | Mutant EPO receptor and uses therefor |
JPH0638787A (ja) * | 1992-03-04 | 1994-02-15 | Snow Brand Milk Prod Co Ltd | 可溶性エリスロポエチン受容体蛋白質、およびそのアミノ酸配列をコードする遺伝子 |
WO1994029458A1 (fr) * | 1993-06-07 | 1994-12-22 | Amgen Inc. | Molecules receptrices hybrides |
EP0742438A2 (fr) * | 1995-05-10 | 1996-11-13 | Bayer Corporation | Triage de librairie peptidiques combinatoires pour sélection de ligand peptidique utile à la purification d'affinité des protéines cibles |
WO1998047089A1 (fr) * | 1997-04-11 | 1998-10-22 | California Institute Of Technology | Dispositif et methode permettant une mise au point informatisee de proteines |
Non-Patent Citations (11)
Title |
---|
BARBONE, F.P. ET AL.: "Mutagenesis Studies of the Human Erythropoietin Receptor", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 8, 21 February 1997 (1997-02-21), pages 4985 - 4992, XP000929145 * |
DAHIYAT B I ET AL: "PROTEIN DESIGN AUTOMATION", PROTEIN SCIENCE,GB,CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, vol. 5, no. 5, 1 May 1996 (1996-05-01), pages 895 - 903, XP002073372, ISSN: 0961-8368 * |
EDDINGTON, S.M.: "Superfamily Structure and Biotech Drug Development", BIOTECHNOLOGY, vol. 10, no. 12, December 1992 (1992-12-01), pages 1529 - 1534, XP000929407 * |
JOHNSON, D.L. ET AL.: "Refolding, Purification, and Characterization of Human Erythropoietin Binding Protein Produced in Escherichia coli", PROTEIN EXPRESSION AND PURIFICATION, vol. 7, no. 1, February 1996 (1996-02-01), pages 104 - 113, XP000925310 * |
JOLLIFFE, L.K. ET AL.: "Erythropoietin receptor: application in drug development", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 10, 1995, pages 28 - 34, XP000925308 * |
LIVNAH, O. ET AL.: "An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation", NATURE STRUCTURAL BIOLOGY, vol. 5, November 1998 (1998-11-01), pages 993 - 1004, XP000925258 * |
MCCONNELL, S.J. ET AL.: "Isolation of Erythropoietin Receptor Agonist Peptides Using Evolved Phage Libraries", BIOLOGICAL CHEMISTRY, vol. 379, October 1998 (1998-10-01), pages 1279 - 1286, XP000925403 * |
MIDDLETON, S.A. ET AL.: "Critical Erythropoietin (EPO) Binding Determinants on the EPO Receptor Also Interact with an EPO Mimetic Peptide", BLOOD, vol. 88, no. 10, 15 November 1996 (1996-11-15), pages 661a, XP000925311 * |
PATENT ABSTRACTS OF JAPAN vol. 018, no. 257 (C - 1200) 17 May 1994 (1994-05-17) * |
QUELLE, D.E. ET AL.: "Mutations in the WSAWSE and Cytosolic Domains of the Erythropoietin Receptor Affect Signal Transduction and Ligand Binding and Internalization", MOLECULAR AND CELLULAR BIOLOGY, vol. 12, no. 10, October 1992 (1992-10-01), pages 4553 - 4561, XP000925397 * |
WRIGHTON, N.C. ET AL.: "Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin", SCIENCE, vol. 273, 5 July 1996 (1996-07-05), pages 458 - 463, XP000925371 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000047612A2 (fr) | 2000-08-17 |
EP1153295A2 (fr) | 2001-11-14 |
AU2880800A (en) | 2000-08-29 |
JP2002540384A (ja) | 2002-11-26 |
CA2362541A1 (fr) | 2000-08-17 |
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