WO2000044889A3 - Mammal with inducible ductal carcinoma in situ - Google Patents

Mammal with inducible ductal carcinoma in situ Download PDF

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Publication number
WO2000044889A3
WO2000044889A3 PCT/DE2000/000232 DE0000232W WO0044889A3 WO 2000044889 A3 WO2000044889 A3 WO 2000044889A3 DE 0000232 W DE0000232 W DE 0000232W WO 0044889 A3 WO0044889 A3 WO 0044889A3
Authority
WO
WIPO (PCT)
Prior art keywords
mammal
ductal carcinoma
inducible
situ
dcis
Prior art date
Application number
PCT/DE2000/000232
Other languages
German (de)
French (fr)
Other versions
WO2000044889A2 (en
Inventor
Christine Schulze-Garg
Wolfgang Deppert
Original Assignee
Mice & More Gmbh & Co Kg
Schulze Garg Christine
Wolfgang Deppert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mice & More Gmbh & Co Kg, Schulze Garg Christine, Wolfgang Deppert filed Critical Mice & More Gmbh & Co Kg
Priority to EP00908941A priority Critical patent/EP1147185A2/en
Publication of WO2000044889A2 publication Critical patent/WO2000044889A2/en
Publication of WO2000044889A3 publication Critical patent/WO2000044889A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

The invention relates to a mammal with inducible ductal carcinoma in situ (DCIS) and containing a prolactin-activated oncogene. The invention also relates to a method for producing such a mammal and to its use for studying a DCIS and the progression thereof towards invasive ductal carcinoma of the breast, as well as for developing diagnostic or therapeutic means for this purpose.
PCT/DE2000/000232 1999-01-28 2000-01-26 Mammal with inducible ductal carcinoma in situ WO2000044889A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP00908941A EP1147185A2 (en) 1999-01-28 2000-01-26 Mammal, method for producing same and its use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19903371.4 1999-01-28
DE1999103371 DE19903371C1 (en) 1999-01-28 1999-01-28 A mammal with inducible in situ ductal carcinoma useful as a model for research and identification of therapeutics

Publications (2)

Publication Number Publication Date
WO2000044889A2 WO2000044889A2 (en) 2000-08-03
WO2000044889A3 true WO2000044889A3 (en) 2000-11-02

Family

ID=7895663

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/000232 WO2000044889A2 (en) 1999-01-28 2000-01-26 Mammal with inducible ductal carcinoma in situ

Country Status (3)

Country Link
EP (1) EP1147185A2 (en)
DE (1) DE19903371C1 (en)
WO (1) WO2000044889A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089073A2 (en) * 2003-04-03 2004-10-21 Genpath Pharmaceuticals, Incorporated Inducible breast cancer model

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009440A1 (en) * 1995-09-06 1997-03-13 Bavarian Nordic Research Institute A/S The use of the wap of mmtv regulatory sequences for targeted expression of linked heterologous genes in human mammary cells, including human mammary carcinoma cells
WO1997039117A1 (en) * 1996-04-17 1997-10-23 The University Of Liverpool Conditionally immortalised cell lines derived from transgenic animals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009440A1 (en) * 1995-09-06 1997-03-13 Bavarian Nordic Research Institute A/S The use of the wap of mmtv regulatory sequences for targeted expression of linked heterologous genes in human mammary cells, including human mammary carcinoma cells
WO1997039117A1 (en) * 1996-04-17 1997-10-23 The University Of Liverpool Conditionally immortalised cell lines derived from transgenic animals

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JÄGER, R. ET AL.: "Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice.", ONCOGENE, vol. 15, no. 15, 9 October 1997 (1997-10-09), pages 1787 - 95, XP000929569 *
ROBINSON, G.W. ET AL.: "Understanding mammary gland development through the imbalanced expression of growth regulators.", DEVELOPMENTAL DYNAMICS, vol. 206, no. 2, 1996, pages 159 - 168, XP000929573 *
SCHULTZ-GARG, C. ET AL.: "A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland.", ONCOGENE, vol. 19, no. 8, 21 February 2000 (2000-02-21), pages 1028 - 37, XP000929607 *
TZENG, Y.J. ET AL.: "SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors.", ONCOGENE, vol. 16, no. 16, 23 April 1998 (1998-04-23), pages 2103 - 14, XP000929570 *
VAN DER MOST, R. G. ET AL.: "Ananlysis of cytotoxic T cell response to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.", JOURNAL OF IMMUNOLOGY, vol. 157, 1996, pages 5543 - 54, XP002143920 *

Also Published As

Publication number Publication date
DE19903371C1 (en) 2000-06-15
WO2000044889A2 (en) 2000-08-03
EP1147185A2 (en) 2001-10-24

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