WO2000042063A3 - Peptides for inhibiting hbv core proteins - Google Patents

Peptides for inhibiting hbv core proteins Download PDF

Info

Publication number
WO2000042063A3
WO2000042063A3 PCT/DE2000/000140 DE0000140W WO0042063A3 WO 2000042063 A3 WO2000042063 A3 WO 2000042063A3 DE 0000140 W DE0000140 W DE 0000140W WO 0042063 A3 WO0042063 A3 WO 0042063A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
core proteins
inhibiting hbv
hbv core
inhibiting
Prior art date
Application number
PCT/DE2000/000140
Other languages
German (de)
French (fr)
Other versions
WO2000042063A2 (en
Inventor
Karin Butz
Felix Hoppe-Seyler
Original Assignee
Deutsches Krebsforsch
Karin Butz
Hoppe Seyler Felix
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Karin Butz, Hoppe Seyler Felix filed Critical Deutsches Krebsforsch
Priority to EP00908930A priority Critical patent/EP1140995A2/en
Priority to JP2000593630A priority patent/JP2002534111A/en
Publication of WO2000042063A2 publication Critical patent/WO2000042063A2/en
Publication of WO2000042063A3 publication Critical patent/WO2000042063A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to peptides which are suitable for inhibiting HBV core proteins, to DNAs which code them and to the use of both, especially for inhibiting HBV replication.
PCT/DE2000/000140 1999-01-13 2000-01-12 Peptides for inhibiting hbv core proteins WO2000042063A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00908930A EP1140995A2 (en) 1999-01-13 2000-01-12 Peptides for inhibiting hbv core proteins
JP2000593630A JP2002534111A (en) 1999-01-13 2000-01-12 HBV core protein inhibitory peptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19901009.9 1999-01-13
DE19901009A DE19901009A1 (en) 1999-01-13 1999-01-13 Peptides to inhibit HBV core proteins

Publications (2)

Publication Number Publication Date
WO2000042063A2 WO2000042063A2 (en) 2000-07-20
WO2000042063A3 true WO2000042063A3 (en) 2000-12-14

Family

ID=7894120

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/000140 WO2000042063A2 (en) 1999-01-13 2000-01-12 Peptides for inhibiting hbv core proteins

Country Status (4)

Country Link
EP (1) EP1140995A2 (en)
JP (1) JP2002534111A (en)
DE (1) DE19901009A1 (en)
WO (1) WO2000042063A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859518B2 (en) 2004-04-22 2014-10-14 Regado Biosciences, Inc. Modulators of coagulation factors

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2325337A1 (en) 2000-09-26 2011-05-25 Duke University RNA aptamers and methods for identifying the same
IL159053A0 (en) 2001-05-25 2004-05-12 Univ Duke Modulators of pharmacological agents
CN102268066B (en) * 2010-06-01 2014-01-22 雷海民 Anti-HBV oligopeptides and derivatives thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9016727D0 (en) * 1990-07-31 1990-09-12 Clonit Spa Amino acid residue sequence of hepatitis b core antigen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MICHAEL R. DYSON ET AL.: "Selection of peptide inhibitors of interactions involved in complex protein assemblies: association of the core and surface antigens of hepatitis B virus", PROC.NATL.ACAD.SCI., vol. 92, 1995, pages 2194 - 8, XP002141206 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859518B2 (en) 2004-04-22 2014-10-14 Regado Biosciences, Inc. Modulators of coagulation factors

Also Published As

Publication number Publication date
JP2002534111A (en) 2002-10-15
WO2000042063A2 (en) 2000-07-20
EP1140995A2 (en) 2001-10-10
DE19901009A1 (en) 2000-07-20

Similar Documents

Publication Publication Date Title
AU2001292757A1 (en) Modified selex processes without purified protein
ZA983496B (en) Methods for processing activated protein C.
WO2001053312A8 (en) Novel nucleic acids and polypeptides
WO2001053455A3 (en) Novel nucleic acids and polypeptides
MXPA02010787A (en) Modified peptides as therapeutic agents.
AU2002217010A1 (en) Peptides, the production and use thereof for binding immunoglobulins
AU6114700A (en) Novel system for the sequential, directional cloning of multiple dna sequences
WO1999020747A3 (en) HUMAN CHECKPOINT KINASE, hCDS1, COMPOSITIONS AND METHODS
EP1129106A4 (en) Cyclised conotoxin peptides
EP1273658A4 (en) Novel protein, dna thereof and process for producing the same
ZA200205408B (en) Process for the preparation of peptides.
AU2001282037A1 (en) Proton-translocating retinal protein
AU2001279581A1 (en) Medicament comprising a dna sequence, which codes for the rna-binding koc protein, and comprising a koc protein or dna sequence of the koc promoter
WO2000042063A3 (en) Peptides for inhibiting hbv core proteins
MXPA04002103A (en) A caspase- 8 binding protein, its preparation and use.
AU2002215386A1 (en) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2001053453A3 (en) Novel bone marrow nucleic acids and polypeptides
AU3556800A (en) Expression of dna or proteins in (c. elegans)
AU2001286687A1 (en) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
AU2001295580A1 (en) Nucleotide sequences which code for the dep67 protein
AU2001290872A1 (en) Isolated human kinase proteins, nucleic acid molecules and uses thereof
AU2002213259A1 (en) Egf motif protein, egfl6 materials and methods
AU2002232599A1 (en) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO1999053091A3 (en) Dna coding for gdnf, parts of said dna and gdnf variants
ZA99445B (en) Isolated, polypeptides which bind to HLA-A29 molecules nucleic acid, the molecules encoding these, and uses thereof.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 593630

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000908930

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09889135

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2000908930

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2000908930

Country of ref document: EP