WO2000041463A3 - Nouveau traitement - Google Patents

Nouveau traitement Download PDF

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Publication number
WO2000041463A3
WO2000041463A3 PCT/EP1999/010295 EP9910295W WO0041463A3 WO 2000041463 A3 WO2000041463 A3 WO 2000041463A3 EP 9910295 W EP9910295 W EP 9910295W WO 0041463 A3 WO0041463 A3 WO 0041463A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
vaccine
combination
antiviral agents
virus
Prior art date
Application number
PCT/EP1999/010295
Other languages
English (en)
Other versions
WO2000041463A2 (fr
Inventor
Gillian Frances Atkinson
Ronald James Boon
Pierre G Vandepapeliere
Martine Anne Cecil Wettendorff
Original Assignee
Smithkline Beecham Biolog
Gillian Frances Atkinson
Ronald James Boon
Pierre G Vandepapeliere
Martine Anne Cecil Wettendorff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020017008833A priority Critical patent/KR20010090011A/ko
Priority to PL99349347A priority patent/PL349347A1/xx
Priority to BR9916893-6A priority patent/BR9916893A/pt
Priority to HU0105070A priority patent/HUP0105070A2/hu
Priority to IL14418699A priority patent/IL144186A0/xx
Priority to EP99965531A priority patent/EP1140163A2/fr
Priority to AU21009/00A priority patent/AU760574B2/en
Priority to JP2000593088A priority patent/JP2002534438A/ja
Application filed by Smithkline Beecham Biolog, Gillian Frances Atkinson, Ronald James Boon, Pierre G Vandepapeliere, Martine Anne Cecil Wettendorff filed Critical Smithkline Beecham Biolog
Priority to CA002359110A priority patent/CA2359110A1/fr
Priority to NZ512890A priority patent/NZ512890A/en
Publication of WO2000041463A2 publication Critical patent/WO2000041463A2/fr
Publication of WO2000041463A3 publication Critical patent/WO2000041463A3/fr
Priority to NO20013337A priority patent/NO20013337L/no
Priority to HK02101211.9A priority patent/HK1041434A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention a trait à un produit pharmaceutique contenant, comme ingrédients actifs (1), un agent antiviral agissant contre le virus de l'hépatite B et (2), un vaccin convenant à la prophylaxie ou au traitement de l'infection par virus de l'hépatite B. Ces ingrédients actifs sont utilisés simultanément ou à la suite. Les composants préférés sont un analogue de nucléoside en tant qu'agent antiviral ainsi qu'un vaccin contre le virus de l'hépatite B renfermant un antigène de surface du virus de l'hépatite B.
PCT/EP1999/010295 1999-01-12 1999-12-21 Nouveau traitement WO2000041463A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AU21009/00A AU760574B2 (en) 1999-01-12 1999-12-21 Novel treatment
BR9916893-6A BR9916893A (pt) 1999-01-12 1999-12-21 Tratamento
HU0105070A HUP0105070A2 (hu) 1999-01-12 1999-12-21 Hepatitis B vírus fertőzések megelőzésére és kezelésére szolgáló készlet
IL14418699A IL144186A0 (en) 1999-01-12 1999-12-21 Novel treatment
EP99965531A EP1140163A2 (fr) 1999-01-12 1999-12-21 Nouveau traitement
KR1020017008833A KR20010090011A (ko) 1999-01-12 1999-12-21 신규 처리
JP2000593088A JP2002534438A (ja) 1999-01-12 1999-12-21 新規治療法
PL99349347A PL349347A1 (en) 1999-01-12 1999-12-21 Novel treatment
CA002359110A CA2359110A1 (fr) 1999-01-12 1999-12-21 Nouveau traitement
NZ512890A NZ512890A (en) 1999-01-12 1999-12-21 Antiviral agents including nucleoside analogues active against hepatitis B virus (HBV)
NO20013337A NO20013337L (no) 1999-01-12 2001-07-05 Ny behandling
HK02101211.9A HK1041434A1 (zh) 1999-01-12 2002-02-19 抗病毒藥物和乙型肝炎疫苗的聯合

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9900630 1999-01-12
GB9900630.6 1999-01-12

Publications (2)

Publication Number Publication Date
WO2000041463A2 WO2000041463A2 (fr) 2000-07-20
WO2000041463A3 true WO2000041463A3 (fr) 2000-11-09

Family

ID=10845878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/010295 WO2000041463A2 (fr) 1999-01-12 1999-12-21 Nouveau traitement

Country Status (19)

Country Link
EP (1) EP1140163A2 (fr)
JP (1) JP2002534438A (fr)
KR (1) KR20010090011A (fr)
CN (1) CN1391482A (fr)
AR (1) AR022250A1 (fr)
AU (1) AU760574B2 (fr)
BR (1) BR9916893A (fr)
CA (1) CA2359110A1 (fr)
CO (1) CO5241355A1 (fr)
CZ (1) CZ20012544A3 (fr)
HK (1) HK1041434A1 (fr)
HU (1) HUP0105070A2 (fr)
IL (1) IL144186A0 (fr)
NO (1) NO20013337L (fr)
NZ (1) NZ512890A (fr)
PL (1) PL349347A1 (fr)
TR (1) TR200102024T2 (fr)
WO (1) WO2000041463A2 (fr)
ZA (1) ZA200105690B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061056A2 (fr) 1998-05-22 1999-12-02 Loeb Health Research Institute At The Ottawa Hospital Methodes et produits permettant d'induire une immunite au niveau des muqueuses
CN1560078B (zh) 1998-07-31 2011-06-22 株式会社国际癌症免疫研究所 基于癌抑制基因wt1的产物的癌抗原
CA2440303C (fr) 2001-03-22 2013-03-19 Haruo Sugiyama Peptide modifie wt1
US8735357B2 (en) 2001-09-28 2014-05-27 International Institute Of Cancer Immunology, Inc. Method of inducing antigen-specific T cells
JPWO2003028758A1 (ja) * 2001-09-28 2005-01-13 治夫 杉山 抗原特異的ｔ細胞の誘導方法
MY131488A (en) * 2002-04-08 2007-08-30 Bristol Myers Squibb Co Low dose liquid entecavir formulations and use
PT2241325E (pt) 2002-10-29 2012-04-12 Coley Pharm Gmbh Utilização de oligonucleótidos cpg no tratamento de infecção com vírus da hepatite c
AU2003300919A1 (en) 2002-12-11 2004-06-30 Coley Pharmaceutical Gmbh 5' cpg nucleic acids and methods of use
CN100443117C (zh) * 2003-05-13 2008-12-17 深圳康泰生物制品股份有限公司 一种治疗性乙型肝炎的疫苗制剂、其制备方法及其用途
US8541167B2 (en) 2004-06-03 2013-09-24 Saint Louis University Methods and compositions for vaccination
AR065504A1 (es) * 2007-02-28 2009-06-10 Ct Ingenieria Genetica Biotech Terapia combinada para el tratamiento de la hepatitis b cronica. uso.
WO2020134682A1 (fr) * 2018-12-24 2020-07-02 南京远大赛威信生物医药有限公司 Préparation pharmaceutique pour le traitement de l'hépatite b, procédé de préparation s'y rapportant et utilisation associée
EP4321173A1 (fr) * 2021-04-07 2024-02-14 Denka Company Limited Activateur d'activité d'adjuvant et composition d'adjuvant

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414374A2 (fr) * 1989-07-25 1991-02-27 Smithkline Biologicals S.A. Antigènes ainsi que les méthodes pour leur préparation
WO1999045957A2 (fr) * 1998-03-09 1999-09-16 Smithkline Beecham Biologicals S.A. Compositions de vaccins combines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414374A2 (fr) * 1989-07-25 1991-02-27 Smithkline Biologicals S.A. Antigènes ainsi que les méthodes pour leur préparation
WO1999045957A2 (fr) * 1998-03-09 1999-09-16 Smithkline Beecham Biologicals S.A. Compositions de vaccins combines

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BERENGUER M ET AL: "Hepatitis B and C viruses: Molecular identification and targeted antiviral therapies", PROCEEDINGS ASSOCIATION OF AMERICAN PHYSICIANS, vol. 110, no. 2, March 1998 (1998-03-01), pages 98 - 112, XP000909240 *
BONI C ET AL: "Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B [see comments].", JOURNAL OF CLINICAL INVESTIGATION, (1998 SEP 1) 102 (5) 968-75., XP000909082 *
GROB P J: "Hepatitis B: virus, pathogenesis and treatment", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 16, no. 1001, November 1998 (1998-11-01), pages S11 - S16, XP004150417, ISSN: 0264-410X *
MOLLOY P J ET AL: "Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa.", HEPATO-GASTROENTEROLOGY, (1999 JUL-AUG) 46 (28) 2529-31., XP000909277 *
PIANKO S. ET AL: "Chronic hepatitis B: New therapies on the horizon?.", LANCET, (13 NOV 1999) 354/9191 (1662-1663)., XP000906960 *
RUDD, JENNIFER N. (1) ET AL: "Possible role for hepatitis B vaccine after lamivudine rescue for severe acute hepatitis B.", GASTROENTEROLOGY, (APRIL, 1999) VOL. 116, NO. 4 PART 2, PP. A1268. MEETING INFO.: DIGESTIVE DISEASE WEEK AND THE 100TH ANNUAL MEETING OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION ORLANDO, FLORIDA, USA MAY 16-19, 1999 AMERICAN GASTROENTEROLOGICAL A, XP000909262 *
SUK-FONG LOK A.: "Hepatitis B infection: Pathogenesis and management.", JOURNAL OF HEPATOLOGY, SUPPLEMENT, (2000) 32/1 (89-97)., XP000909278 *
VALDEZ H ET AL: "Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen. ACTG 375 team. AIDS Clinical Trials Group.", AIDS, (2000 JAN 7) 14 (1) 11-21., XP000909260 *

Also Published As

Publication number Publication date
KR20010090011A (ko) 2001-10-17
TR200102024T2 (tr) 2001-12-21
EP1140163A2 (fr) 2001-10-10
CZ20012544A3 (cs) 2002-01-16
AR022250A1 (es) 2002-09-04
JP2002534438A (ja) 2002-10-15
HK1041434A1 (zh) 2002-07-12
NO20013337L (no) 2001-08-17
PL349347A1 (en) 2002-07-15
IL144186A0 (en) 2002-05-23
ZA200105690B (en) 2002-09-25
NO20013337D0 (no) 2001-07-05
WO2000041463A2 (fr) 2000-07-20
AU2100900A (en) 2000-08-01
CA2359110A1 (fr) 2000-07-20
CO5241355A1 (es) 2003-01-31
NZ512890A (en) 2003-09-26
BR9916893A (pt) 2001-11-20
HUP0105070A2 (hu) 2002-04-29
AU760574B2 (en) 2003-05-15
CN1391482A (zh) 2003-01-15

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