WO2000040606A3 - Modulation of hiv replication using sam68 - Google Patents

Modulation of hiv replication using sam68 Download PDF

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Publication number
WO2000040606A3
WO2000040606A3 PCT/US2000/000324 US0000324W WO0040606A3 WO 2000040606 A3 WO2000040606 A3 WO 2000040606A3 US 0000324 W US0000324 W US 0000324W WO 0040606 A3 WO0040606 A3 WO 0040606A3
Authority
WO
WIPO (PCT)
Prior art keywords
sam68
expression
host cell
replication
retroviral
Prior art date
Application number
PCT/US2000/000324
Other languages
French (fr)
Other versions
WO2000040606A2 (en
Inventor
Flossie Wong-Staal
Thipparthi Reddy
Weidong Xu
Original Assignee
Univ California
Wong Staal Flossie
Thipparthi Reddy
Weidong Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Wong Staal Flossie, Thipparthi Reddy, Weidong Xu filed Critical Univ California
Priority to AU24933/00A priority Critical patent/AU2493300A/en
Publication of WO2000040606A2 publication Critical patent/WO2000040606A2/en
Publication of WO2000040606A3 publication Critical patent/WO2000040606A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention features methods and products for modifying retrovirus replication or expression in a host cell. Specifically, the invention relates to the use of cellular nuclear export proteins such as Sam68 and homologs, analogs, and derivatives thereof that can effect retroviral replication or expression in a host cell. Depending on whether desired enhanced or impeded, different specific applications and embodiments apply. For the latter, various negative transdominant mutants of Sam68 are disclosed that are likely to have great utiliy as research implements in, e.g., cell culture, transgenic animals, and in medicine as pharmaceutical compositions and techniques for ameliorating retroviral disease symptoms and etiology in afflicted organisms, i.e., humans.
PCT/US2000/000324 1999-01-06 2000-01-06 Modulation of hiv replication using sam68 WO2000040606A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24933/00A AU2493300A (en) 1999-01-06 2000-01-06 Modulation of hiv replication using sam68

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11484899P 1999-01-06 1999-01-06
US60/114,848 1999-01-06
US14052499P 1999-06-22 1999-06-22
US60/140,524 1999-06-22

Publications (2)

Publication Number Publication Date
WO2000040606A2 WO2000040606A2 (en) 2000-07-13
WO2000040606A3 true WO2000040606A3 (en) 2000-11-30

Family

ID=26812599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/000324 WO2000040606A2 (en) 1999-01-06 2000-01-06 Modulation of hiv replication using sam68

Country Status (2)

Country Link
AU (1) AU2493300A (en)
WO (1) WO2000040606A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0406557A2 (en) * 1989-05-25 1991-01-09 Sandoz Ltd. Multivalent repressor of gene function
WO1992020794A1 (en) * 1991-05-17 1992-11-26 Cetus Oncology Corporation Purification and cloning of p62
WO1996028189A1 (en) * 1995-03-06 1996-09-19 Baylor College Of Medicine A double transdominant fusion gene and protein
FR2734826A1 (en) * 1995-06-01 1996-12-06 Rhone Poulenc Rorer Sa DELTAP62, ITS VARIANTS, NUCLEIC SEQUENCES AND THEIR USES
WO1997039128A2 (en) * 1996-04-15 1997-10-23 Ribotargets Limited Use of a modified rev-responsive element (rre) in methods and compositions for combatting hiv infection
WO1999015657A2 (en) * 1997-09-23 1999-04-01 Curagen Corporation 53bp2 complexes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0406557A2 (en) * 1989-05-25 1991-01-09 Sandoz Ltd. Multivalent repressor of gene function
WO1992020794A1 (en) * 1991-05-17 1992-11-26 Cetus Oncology Corporation Purification and cloning of p62
WO1996028189A1 (en) * 1995-03-06 1996-09-19 Baylor College Of Medicine A double transdominant fusion gene and protein
FR2734826A1 (en) * 1995-06-01 1996-12-06 Rhone Poulenc Rorer Sa DELTAP62, ITS VARIANTS, NUCLEIC SEQUENCES AND THEIR USES
WO1997039128A2 (en) * 1996-04-15 1997-10-23 Ribotargets Limited Use of a modified rev-responsive element (rre) in methods and compositions for combatting hiv infection
WO1999015657A2 (en) * 1997-09-23 1999-04-01 Curagen Corporation 53bp2 complexes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BARLAT ISABELLE ET AL: "A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 6, 1997, pages 3129 - 3132, XP002141542, ISSN: 0021-9258 *
HOPE T J ET AL: "EFFECTOR DOMAINS OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REV AND HUMAN T-CELL LEUKEMIA VIRUS TYPE I REX ARE FUNCTIONALLY INTERCHANGEABLE AND SHARE AN ESSENTIAL PEPTIDE MOTIF", JOURNAL OF VIROLOGY,US,NEW YORK, US, vol. 65, no. 11, 1 November 1991 (1991-11-01), pages 6001 - 6007, XP000615339, ISSN: 0022-538X *
MALIN M H ET AL: "STABLE EXPRESSION OF TRANSDOMINANT REV PROTEIN IN HUMAN T CELLS INHIBITS HUMAN IMMUNODEFICIENCY VIRUS REPLICATION", JOURNAL OF EXPERIMENTAL MEDICINE,JP,TOKYO, vol. 176, 1 October 1992 (1992-10-01), pages 1197 - 1201, XP002005558, ISSN: 0022-1007 *
MCBRIDE A E ET AL: "Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1996, vol. 93, no. 6, 1996, pages 2296 - 2301, XP002141541, ISSN: 0027-8424 *
MCBRIDE A E ET AL: "KH domain integrity is required for wild-type localization of Sam68.", EXPERIMENTAL CELL RESEARCH MAY 25, 1998, vol. 241, no. 1, 25 May 1998 (1998-05-25), pages 84 - 95, XP000922543, ISSN: 0014-4827 *
REDDY THIPPARTHI R ET AL: "Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.", NATURE MEDICINE JUNE, 1999, vol. 5, no. 6, June 1999 (1999-06-01), pages 635 - 642, XP000864675, ISSN: 1078-8956 *
RICHARD S ET AL: "ASSOCIATION OF P62, A MULTIFUNCTIONAL SH2- AND SH3-DOMAIN-BINDING PROTEIN, WITH SRC FAMILY TYROSINE KINASES, GBR2, AND PHOSPHOLIPASE CGAMMY-1", MOLECULAR AND CELLULAR BIOLOGY,US,WASHINGTON, DC, vol. 15, no. 1, 1 January 1995 (1995-01-01), pages 186 - 197, XP000562643, ISSN: 0270-7306 *

Also Published As

Publication number Publication date
WO2000040606A2 (en) 2000-07-13
AU2493300A (en) 2000-07-24

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