WO2000036101A3 - An atp-binding cassette protein responsible for cytotoxin resistance - Google Patents

An atp-binding cassette protein responsible for cytotoxin resistance Download PDF

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Publication number
WO2000036101A3
WO2000036101A3 PCT/US1999/028107 US9928107W WO0036101A3 WO 2000036101 A3 WO2000036101 A3 WO 2000036101A3 US 9928107 W US9928107 W US 9928107W WO 0036101 A3 WO0036101 A3 WO 0036101A3
Authority
WO
WIPO (PCT)
Prior art keywords
atp
binding cassette
protein responsible
cassette protein
cytotoxin
Prior art date
Application number
PCT/US1999/028107
Other languages
French (fr)
Other versions
WO2000036101A2 (en
Inventor
Michael Dean
Rando Allikmets
Susan E Bates
Antonio T Fojo
Original Assignee
Us Gov Health & Human Serv
Michael Dean
Rando Allikmets
Susan E Bates
Antonio T Fojo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Michael Dean, Rando Allikmets, Susan E Bates, Antonio T Fojo filed Critical Us Gov Health & Human Serv
Priority to US09/856,927 priority Critical patent/US7138493B1/en
Priority to AU19240/00A priority patent/AU1924000A/en
Publication of WO2000036101A2 publication Critical patent/WO2000036101A2/en
Publication of WO2000036101A3 publication Critical patent/WO2000036101A3/en
Priority to US11/588,744 priority patent/US20070048810A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention provides for ATP-binding cassette protein which is responsible for cytotoxin resistance. The invention also provides for methods of expressing the protein and assays for identification of inhibitors of the protein.
PCT/US1999/028107 1998-11-30 1999-11-24 An atp-binding cassette protein responsible for cytotoxin resistance WO2000036101A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US09/856,927 US7138493B1 (en) 1998-11-30 1999-11-24 ATP-binding cassette protein responsible for cytotoxin resistance
AU19240/00A AU1924000A (en) 1998-11-30 1999-11-24 An atp-binding cassette protein responsible for cytotoxin resistance
US11/588,744 US20070048810A1 (en) 1998-11-30 2006-10-26 ATP-binding cassette protein responsible for cytotoxin resistance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11047398P 1998-11-30 1998-11-30
US60/110,473 1998-11-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/588,744 Division US20070048810A1 (en) 1998-11-30 2006-10-26 ATP-binding cassette protein responsible for cytotoxin resistance

Publications (2)

Publication Number Publication Date
WO2000036101A2 WO2000036101A2 (en) 2000-06-22
WO2000036101A3 true WO2000036101A3 (en) 2002-08-29

Family

ID=22333197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028107 WO2000036101A2 (en) 1998-11-30 1999-11-24 An atp-binding cassette protein responsible for cytotoxin resistance

Country Status (2)

Country Link
AU (1) AU1924000A (en)
WO (1) WO2000036101A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2319715C (en) 1998-02-05 2012-08-07 University Of Maryland, Baltimore Breast cancer resistance protein (bcrp) and the dna which encodes it
WO2002024742A2 (en) * 2000-09-22 2002-03-28 Incyte Genomics, Inc. Atp-binding cassette protein
WO2003035685A1 (en) * 2001-10-24 2003-05-01 Solvo Biotechnology Inc. Use of a half-transporter protein of the abcg-family for selecting cells and in gene therapy
CN106432490B (en) 2016-09-14 2020-01-07 北京大学 ABCG2 monoclonal antibody and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055614A2 (en) * 1997-06-04 1998-12-10 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1999040110A1 (en) * 1998-02-05 1999-08-12 University Of Maryland, Baltimore Breast cancer resistance protein (bcrp) and the dna which encodes it

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055614A2 (en) * 1997-06-04 1998-12-10 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1999040110A1 (en) * 1998-02-05 1999-08-12 University Of Maryland, Baltimore Breast cancer resistance protein (bcrp) and the dna which encodes it

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ALLIKMETS R ET AL: "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the Expressed Sequence Tags Database", HUMAN MOLECULAR GENETICS,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 5, no. 10, 1996, pages 1649 - 1655, XP002120400, ISSN: 0964-6906 *
BRUIN DE M ET AL: "REVERSAL OF RESISTANCE BY GF120918 IN CELL LINES EXPRESSING THE ABC HALF-TRANSPORTER, MXR", CANCER LETTERS,US,NEW YORK, NY, vol. 146, 1999, pages 117 - 126, XP000878698, ISSN: 0304-3835 *
DOYLE, L.A. ET AL.: "Cloning and characterization of Breast Cancer Resistance Protein (BCRP), a novel ATP-binding cassette (ABC) transporter that may contribute to the multidrug-resistance phenotype of MCF-7/AdrVp breast cancer cells.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 39, 28 March 1998 (1998-03-28) - 1 April 1998 (1998-04-01), pages 657, XP000891682 *
JONG SEOK LEE ET AL.: "Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-Glycoprotein or MRP overexpression", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 65, no. 4, 15 June 1997 (1997-06-15), pages 513 - 526, XP002135021 *
KEISUKE MIYAKE ET AL.: "Molecular cloning of cDNAs which are highly overexpressed in Mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes", CANCER RESEARCH, vol. 59, no. 1, 1 January 1999 (1999-01-01), MD US, pages 8 - 13, XP002135022 *
L. AUSTIN DOYLE ET AL.: "A multidrug resistance transporter from human MCF-7 breast cancer cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 95, no. 26, 22 December 1998 (1998-12-22), WASHINGTON US, pages 15665 - 15670, XP002135024 *
LAGE H ET AL: "Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, vol. 188, no. 2, 1 April 1997 (1997-04-01), pages 151 - 156, XP004059294, ISSN: 0378-1119 *
RANDO ALLIKMETS ET AL.: "A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance", CANCER RESEARCH, vol. 58, no. 23, 1 December 1998 (1998-12-01), MD US, pages 5337 - 5339, XP002135023 *

Also Published As

Publication number Publication date
AU1924000A (en) 2000-07-03
WO2000036101A2 (en) 2000-06-22

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