WO2000035407A3 - Inhibition de l'angiogenese par des analogues de peptides du domaine 3 du kininogene a poids moleculaire eleve - Google Patents

Inhibition de l'angiogenese par des analogues de peptides du domaine 3 du kininogene a poids moleculaire eleve Download PDF

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Publication number
WO2000035407A3
WO2000035407A3 PCT/US1999/028465 US9928465W WO0035407A3 WO 2000035407 A3 WO2000035407 A3 WO 2000035407A3 US 9928465 W US9928465 W US 9928465W WO 0035407 A3 WO0035407 A3 WO 0035407A3
Authority
WO
WIPO (PCT)
Prior art keywords
angiogenesis
molecular weight
high molecular
phe
ala
Prior art date
Application number
PCT/US1999/028465
Other languages
English (en)
Other versions
WO2000035407A2 (fr
Inventor
R Keith Mccrae
Original Assignee
Univ Temple
R Keith Mccrae
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple, R Keith Mccrae filed Critical Univ Temple
Priority to AU17494/00A priority Critical patent/AU774694B2/en
Priority to JP2000587728A priority patent/JP2002532400A/ja
Priority to NZ512837A priority patent/NZ512837A/en
Priority to IL14365199A priority patent/IL143651A0/xx
Priority to CA002355287A priority patent/CA2355287A1/fr
Priority to EP99960639A priority patent/EP1140130A4/fr
Publication of WO2000035407A2 publication Critical patent/WO2000035407A2/fr
Publication of WO2000035407A3 publication Critical patent/WO2000035407A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des analogues de peptides du domaine 3 du kininogène à poids moléculaire élevé, qui constituent des inhibiteurs puissants de l'angiogenèse. Les peptides sont représentés par la formule (a) X1-Asn-Asn-Ala-Thr-Phe-Tyr-Phe-Lys-X2, (b) X3-Cys-Val-Gly-Cys-X4, (c) X5-Leu-Asp-X7-Asn-Ala-Glu-Val-Tyr-X6, ou (d) Tyr-Phe-lle-Asp-Phe-Val-Ala-Arg-Glu-Thr-Thr-X7-Ser-Lys-Glu-Ser, dans laquelle X1, X2, X3, X4, X5 et X6 représentent de zéro à douze acides aminés indépendamment identiques ou différents, et de préférence de zéro à six acides aminés, et X7 est Ala ou Cys. Les peptides peuvent également comporter des fragments biologiquement actifs du domaine 3 du kininogène à poids moléculaire élevé. L'invention concerne des procédés permettant d'inhiber la prolifération de cellules endothéliales et l'angiogenèse.
PCT/US1999/028465 1998-12-16 1999-12-02 Inhibition de l'angiogenese par des analogues de peptides du domaine 3 du kininogene a poids moleculaire eleve WO2000035407A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU17494/00A AU774694B2 (en) 1998-12-16 1999-12-02 Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs
JP2000587728A JP2002532400A (ja) 1998-12-16 1999-12-02 高分子キニノゲンドメイン３ペプチド類似体による血管形成の阻害
NZ512837A NZ512837A (en) 1998-12-16 1999-12-02 Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs
IL14365199A IL143651A0 (en) 1998-12-16 1999-12-02 Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs
CA002355287A CA2355287A1 (fr) 1998-12-16 1999-12-02 Inhibition de l'angiogenese par des analogues de peptides du domaine 3 du kininogene a poids moleculaire eleve
EP99960639A EP1140130A4 (fr) 1998-12-16 1999-12-02 Inhibition de l'angiogenese par des analogues de peptides du domaine 3 du kininogene a poids moleculaire eleve

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11242798P 1998-12-16 1998-12-16
US60/112,427 1998-12-16

Publications (2)

Publication Number Publication Date
WO2000035407A2 WO2000035407A2 (fr) 2000-06-22
WO2000035407A3 true WO2000035407A3 (fr) 2000-09-08

Family

ID=22343848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028465 WO2000035407A2 (fr) 1998-12-16 1999-12-02 Inhibition de l'angiogenese par des analogues de peptides du domaine 3 du kininogene a poids moleculaire eleve

Country Status (8)

Country Link
EP (1) EP1140130A4 (fr)
JP (1) JP2002532400A (fr)
AU (1) AU774694B2 (fr)
CA (1) CA2355287A1 (fr)
IL (1) IL143651A0 (fr)
NZ (1) NZ512837A (fr)
WO (1) WO2000035407A2 (fr)
ZA (1) ZA200105740B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920000D0 (en) * 1999-08-25 1999-10-27 Imp Cancer Res Tech Polypeptides
US7098187B2 (en) 2002-09-13 2006-08-29 Attenuon, Llc Human kininogen D3 domain polypeptide as an anti-angiogenic and anti-tumor agent
KR100758006B1 (ko) 2005-09-28 2007-09-11 강원대학교산학협력단 신생혈관 형성, 및 염증에 대한 억제 활성을 갖는 폴리펩티드 및 상기 폴리펩티드를 포함하는 약학 조성물
KR102167755B1 (ko) * 2018-05-23 2020-10-19 주식회사 큐어바이오 단편화된 grs 폴리펩타이드, 이의 변이체 및 이들의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041640A1 (fr) * 1995-06-09 1996-12-27 The Regents Of The University Of Michigan Analogues de la bradykinine utilises comme inhibiteurs selectifs de la thrombine
US5817748A (en) * 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817748A (en) * 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX
WO1996041640A1 (fr) * 1995-06-09 1996-12-27 The Regents Of The University Of Michigan Analogues de la bradykinine utilises comme inhibiteurs selectifs de la thrombine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COLMAN ET AL.: "Contact System: A Vascular Biology MOdulator with Anticoagulant, Profibrinolytic, Antiadhesive and Proinflammatory Attributes", BLOOD,, vol. 90, no. 10, 15 November 1997 (1997-11-15), pages 3819 - 3843, XP002928335 *

Also Published As

Publication number Publication date
EP1140130A2 (fr) 2001-10-10
ZA200105740B (en) 2002-07-12
AU774694B2 (en) 2004-07-01
AU1749400A (en) 2000-07-03
JP2002532400A (ja) 2002-10-02
CA2355287A1 (fr) 2000-06-22
EP1140130A4 (fr) 2003-05-14
WO2000035407A2 (fr) 2000-06-22
NZ512837A (en) 2003-08-29
IL143651A0 (en) 2002-04-21

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