WO2000032577A3 - Substituted benzo[de]isoquinoline-1,3-diones - Google Patents

Substituted benzo[de]isoquinoline-1,3-diones Download PDF

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Publication number
WO2000032577A3
WO2000032577A3 PCT/EP1999/008561 EP9908561W WO0032577A3 WO 2000032577 A3 WO2000032577 A3 WO 2000032577A3 EP 9908561 W EP9908561 W EP 9908561W WO 0032577 A3 WO0032577 A3 WO 0032577A3
Authority
WO
WIPO (PCT)
Prior art keywords
diones
isoquinoline
substituted benzo
benzo
substituted
Prior art date
Application number
PCT/EP1999/008561
Other languages
French (fr)
Other versions
WO2000032577A2 (en
Inventor
Werner Mederski
Ralf Devant
Gerhard Barnickel
Sabine Bernotat-Danielowski
Guido Melzer
Peter Raddatz
Zhengdong Wu
Daljit Dhanoa
Richard Soll
James Rinker
Todd Graybill
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020017006547A priority Critical patent/KR20010080569A/en
Priority to JP2000585219A priority patent/JP2002537225A/en
Priority to CA002352045A priority patent/CA2352045A1/en
Priority to AU26603/00A priority patent/AU760136B2/en
Priority to PL99348204A priority patent/PL348204A1/en
Priority to HU0104520A priority patent/HUP0104520A3/en
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Priority to BR9915648-2A priority patent/BR9915648A/en
Priority to SK702-2001A priority patent/SK7022001A3/en
Priority to EP99968783A priority patent/EP1144381A2/en
Publication of WO2000032577A2 publication Critical patent/WO2000032577A2/en
Publication of WO2000032577A3 publication Critical patent/WO2000032577A3/en
Priority to NO20012544A priority patent/NO20012544L/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Novel compounds of formula (I) in which R, R?1 and R2¿ have the meaning indicated, and their salts or solvates as glycoprotein IbIX antagonists.
PCT/EP1999/008561 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones WO2000032577A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2000585219A JP2002537225A (en) 1998-11-25 1999-11-09 Substituted benzo [de] isoquinoline-1,3-diones
CA002352045A CA2352045A1 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones
AU26603/00A AU760136B2 (en) 1998-11-25 1999-11-09 Substituted benzo(DE)isoquinoline-1,3-diones
PL99348204A PL348204A1 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones
HU0104520A HUP0104520A3 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones process for their preparation and pharmaceutical compositions containing them
KR1020017006547A KR20010080569A (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones
BR9915648-2A BR9915648A (en) 1998-11-25 1999-11-09 Benzo [de] substituted isoquinoline-1,3-diones
SK702-2001A SK7022001A3 (en) 1998-11-25 1999-11-09 Derivative of benzo[de]isoquinoline-1,3-dione, process for the preparation thereof, use thereof and pharmaceutical composition comprising the same
EP99968783A EP1144381A2 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones
NO20012544A NO20012544L (en) 1998-11-25 2001-05-23 Substituted benzo [de] isoquinoline-1,3-dione

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19941398A 1998-11-25 1998-11-25
US39878399A 1999-09-20 1999-09-20
US09/199,413 1999-09-20
US09/398,783 1999-09-20

Publications (2)

Publication Number Publication Date
WO2000032577A2 WO2000032577A2 (en) 2000-06-08
WO2000032577A3 true WO2000032577A3 (en) 2000-09-21

Family

ID=26894745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/008561 WO2000032577A2 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones

Country Status (15)

Country Link
EP (1) EP1144381A2 (en)
JP (1) JP2002537225A (en)
KR (1) KR20010080569A (en)
CN (1) CN1330638A (en)
AU (1) AU760136B2 (en)
BR (1) BR9915648A (en)
CA (1) CA2352045A1 (en)
CZ (1) CZ20011782A3 (en)
HU (1) HUP0104520A3 (en)
ID (1) ID28982A (en)
NO (1) NO20012544L (en)
PL (1) PL348204A1 (en)
SK (1) SK7022001A3 (en)
TW (1) TW473474B (en)
WO (1) WO2000032577A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6429212B1 (en) * 1996-08-16 2002-08-06 Ishihara Sangyo Kaisha Ltd. Medicinal composition
EP1088821A1 (en) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
WO2003007931A1 (en) * 2001-06-08 2003-01-30 Institute Of Medicinal Molecular Design. Inc. Sulfonamide derivatives
US6693198B2 (en) * 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
US8097725B2 (en) 2004-12-03 2012-01-17 Roche Diagnostics Operations, Inc. Luminescent indicator dye and optical sensor
FR2915685A1 (en) * 2007-05-02 2008-11-07 Thales Sa New fluorescent compounds of solid state in water, with naphthalimide base, useful for allowing the grafting on transducer, which is a biological substance, in biosensor and security or explosive detectors, and as markers
EP2970227B1 (en) 2013-03-15 2018-01-10 Alumend, LLC Compositions and methods of using the compositions for plaque softening
US9662324B2 (en) 2013-05-01 2017-05-30 Academia Sinica Methods and compositions for treating β-thalassemia and sickle cell disease
CN103450176B (en) * 2013-08-15 2016-07-06 大连理工大学 One class is containing 2-(4-aminophenyl) benzothiazole naphthalimide compound and application thereof
US20170283408A1 (en) * 2014-09-19 2017-10-05 Yen-Ta Lu Benzo-heterocyclic compounds and their applications
CN106905237B (en) * 2017-02-08 2019-05-14 上海师范大学 A kind of pH and weary oxygen double-bang firecracker answer the naphthalimide ratio fluorescent probe and its synthetic method of positioning tumor cell
CN110283123B (en) * 2019-07-08 2022-06-17 桂林医学院 4-p-toluenesulfonyl piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof
CN110272388B (en) * 2019-07-08 2022-06-17 桂林医学院 4-dithioformic acid piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof
CN110407865B (en) * 2019-08-02 2022-04-15 山东师范大学 Benzene sulfonamide structure-based compound shown as formula (I) and preparation method and application thereof
CN111518075B (en) * 2020-04-17 2023-03-28 西南大学 Naphthalimide piperazine triazole compound and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2271215A1 (en) * 1974-05-15 1975-12-12 Hoechst Ag
FR2392978A2 (en) * 1977-06-04 1978-12-29 Made Labor Sa SUBSTITUTE NAPHTHALIMIDES FOR USE AS MEDICINAL PRODUCTS
EP0268093A1 (en) * 1986-10-21 1988-05-25 Knoll Ag 5-Nitrobenzo[de]isoquinoline-1,3 diones, their preparation and use
WO1998017278A1 (en) * 1996-10-21 1998-04-30 Allelix Biopharmaceuticals Inc. Neurotrophin antagonist compositions
WO1998018764A1 (en) * 1996-10-28 1998-05-07 Merck Patent Gmbh Dihydrobenzoanthracenone, -pyrimidinone or dihydronaphtoquinolinone

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2271215A1 (en) * 1974-05-15 1975-12-12 Hoechst Ag
FR2392978A2 (en) * 1977-06-04 1978-12-29 Made Labor Sa SUBSTITUTE NAPHTHALIMIDES FOR USE AS MEDICINAL PRODUCTS
EP0268093A1 (en) * 1986-10-21 1988-05-25 Knoll Ag 5-Nitrobenzo[de]isoquinoline-1,3 diones, their preparation and use
WO1998017278A1 (en) * 1996-10-21 1998-04-30 Allelix Biopharmaceuticals Inc. Neurotrophin antagonist compositions
WO1998018764A1 (en) * 1996-10-28 1998-05-07 Merck Patent Gmbh Dihydrobenzoanthracenone, -pyrimidinone or dihydronaphtoquinolinone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KEN-ICHI N ET AL: "N-Aryl-1,8-naphtalimides as highly sensitive fluorescent labeling reagents for canitine", DYES AND PIGMENTS., vol. 43, no. 3, 14 October 1999 (1999-10-14), ELSEVIER APPLIED SCIENCE PUBLISHERS. BARKING., GB, pages 235 - 239, XP002138322, ISSN: 0143-7208 *

Also Published As

Publication number Publication date
ID28982A (en) 2001-07-19
CA2352045A1 (en) 2000-06-08
HUP0104520A3 (en) 2002-10-28
KR20010080569A (en) 2001-08-22
NO20012544D0 (en) 2001-05-23
AU2660300A (en) 2000-06-19
HUP0104520A2 (en) 2002-04-29
TW473474B (en) 2002-01-21
SK7022001A3 (en) 2002-09-10
EP1144381A2 (en) 2001-10-17
PL348204A1 (en) 2002-05-06
NO20012544L (en) 2001-05-23
WO2000032577A2 (en) 2000-06-08
BR9915648A (en) 2001-08-14
CN1330638A (en) 2002-01-09
CZ20011782A3 (en) 2001-09-12
AU760136B2 (en) 2003-05-08
JP2002537225A (en) 2002-11-05

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