WO2000023567A3 - Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors - Google Patents
Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors Download PDFInfo
- Publication number
- WO2000023567A3 WO2000023567A3 PCT/EP1999/007741 EP9907741W WO0023567A3 WO 2000023567 A3 WO2000023567 A3 WO 2000023567A3 EP 9907741 W EP9907741 W EP 9907741W WO 0023567 A3 WO0023567 A3 WO 0023567A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem cells
- histone deacetylase
- renewal
- self
- hematopoietic stem
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002346152A CA2346152A1 (en) | 1998-10-16 | 1999-10-14 | Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors |
JP2000577279A JP2002527101A (en) | 1998-10-16 | 1999-10-14 | Improved transduction of hematopoietic stem cells and promotion of self-renewal by histone deacetylase inhibitors |
EP99950725A EP1129175A2 (en) | 1998-10-16 | 1999-10-14 | Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors |
AU63393/99A AU6339399A (en) | 1998-10-16 | 1999-10-14 | Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17363398A | 1998-10-16 | 1998-10-16 | |
US13247699P | 1999-05-04 | 1999-05-04 | |
US60/132,476 | 1999-05-04 | ||
US09/173,633 | 1999-05-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000023567A2 WO2000023567A2 (en) | 2000-04-27 |
WO2000023567A3 true WO2000023567A3 (en) | 2000-07-27 |
Family
ID=26830391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/007741 WO2000023567A2 (en) | 1998-10-16 | 1999-10-14 | Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1129175A2 (en) |
JP (1) | JP2002527101A (en) |
AU (1) | AU6339399A (en) |
CA (1) | CA2346152A1 (en) |
WO (1) | WO2000023567A2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7732475B2 (en) | 2005-07-14 | 2010-06-08 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
US8058065B2 (en) | 2005-12-13 | 2011-11-15 | Kyoto University | Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells |
US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
US8211697B2 (en) | 2007-06-15 | 2012-07-03 | Kyoto University | Induced pluripotent stem cells produced using reprogramming factors and a rho kinase inhibitor or a histone deacetylase inhibitor |
US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
US9499797B2 (en) | 2008-05-02 | 2016-11-22 | Kyoto University | Method of making induced pluripotent stem cells |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5032669A (en) * | 1990-05-01 | 1991-07-16 | University Of Massachusetts At Amherst | Liquid crystalline polyesters formed by reaction of bis(hydroxyalkoxy) biphenyls with terephthaloyl chloride |
AU2002243231A1 (en) | 2000-11-21 | 2002-07-24 | Wake Forest University | Method of treating autoimmune diseases |
DE10162080A1 (en) * | 2001-12-10 | 2003-06-26 | Albrecht Mueller | Process for the production of stem cells with increased development potential |
DE60331297D1 (en) | 2002-03-07 | 2010-04-01 | Univ Delaware | METHOD OF REINFORCING THE OLIGONUCLEOTIDE-mediated NUCLEIC ACID SEQUENCE CHANGE USING HYDROXYAL COMPOSITION COMPOSITIONS |
ATE497533T1 (en) * | 2004-05-05 | 2011-02-15 | Zorica Becker-Kojic | USE OF GLYCOPROTEIN ACA ANTIBODIES FOR OBTAINING OR MAINTAINING PLURIPOTENT NON-EMBRYONAL STEM CELLS |
ATE527341T1 (en) * | 2004-10-27 | 2011-10-15 | Univ Bruxelles | HEPATIC DIFFERENTIATION OF STEM CELLS |
JP5010760B2 (en) | 2010-10-05 | 2012-08-29 | タカラバイオ株式会社 | Method for producing viral vector |
SG10201602423TA (en) | 2011-09-30 | 2016-05-30 | Bluebird Bio Inc | Compounds For Improved Viral Transduction |
WO2013141133A1 (en) | 2012-03-22 | 2013-09-26 | タカラバイオ株式会社 | Method for producing viral vector |
WO2013146480A1 (en) * | 2012-03-29 | 2013-10-03 | タカラバイオ株式会社 | Gene introduction method |
JP6551963B2 (en) * | 2014-05-14 | 2019-07-31 | 国立大学法人京都大学 | Method for producing megakaryocyte precursor cells |
WO2018088821A1 (en) * | 2016-11-10 | 2018-05-17 | 울산대학교 산학협력단 | Composition for promoting stem cell activity, comprising histone deacetylase inhibitor and priming factor as active ingredients |
KR102097191B1 (en) * | 2016-11-10 | 2020-04-06 | 울산대학교 산학협력단 | Composition for enforcing the priming effect of stem cell comprising histone deacetylase inhibitor and priming factors |
WO2021207673A1 (en) * | 2020-04-09 | 2021-10-14 | The Regents of the University of Colorodo, a body corporate | Compositions, methods and uses for production of hematopoietic stem cells (hscs) |
EP4146797A1 (en) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Treatment for neurodegenerative diseases |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0627487A2 (en) * | 1993-05-24 | 1994-12-07 | Immunex Corporation | Ligands for FLT3 receptors |
WO1997016535A2 (en) * | 1995-10-30 | 1997-05-09 | Novartis Ag | METHODS FOR USE OF Mpl LIGANDS WITH PRIMITIVE HUMAN STEM CELLS |
EP0827742A1 (en) * | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone deacetylase inhibitors for treating fribosis or cirrhosis |
-
1999
- 1999-10-14 CA CA002346152A patent/CA2346152A1/en not_active Abandoned
- 1999-10-14 EP EP99950725A patent/EP1129175A2/en not_active Withdrawn
- 1999-10-14 JP JP2000577279A patent/JP2002527101A/en active Pending
- 1999-10-14 WO PCT/EP1999/007741 patent/WO2000023567A2/en not_active Application Discontinuation
- 1999-10-14 AU AU63393/99A patent/AU6339399A/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0627487A2 (en) * | 1993-05-24 | 1994-12-07 | Immunex Corporation | Ligands for FLT3 receptors |
WO1997016535A2 (en) * | 1995-10-30 | 1997-05-09 | Novartis Ag | METHODS FOR USE OF Mpl LIGANDS WITH PRIMITIVE HUMAN STEM CELLS |
EP0827742A1 (en) * | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone deacetylase inhibitors for treating fribosis or cirrhosis |
EP0827743A1 (en) * | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone decarboxylase inhibitors for treating fibrosis |
Non-Patent Citations (1)
Title |
---|
LAVAU C. ET AL.: "Inhibitors of histone deacetylases promote primitive hematopoietoic cell self-renewal in ex vivo culture", BLOOD, vol. 92, 15 November 1998 (1998-11-15), pages 504a - 505a, XP000904836 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7732475B2 (en) | 2005-07-14 | 2010-06-08 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US7741494B2 (en) | 2005-07-14 | 2010-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
US8058065B2 (en) | 2005-12-13 | 2011-11-15 | Kyoto University | Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells |
US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
US8211697B2 (en) | 2007-06-15 | 2012-07-03 | Kyoto University | Induced pluripotent stem cells produced using reprogramming factors and a rho kinase inhibitor or a histone deacetylase inhibitor |
US8257941B2 (en) | 2007-06-15 | 2012-09-04 | Kyoto University | Methods and platforms for drug discovery using induced pluripotent stem cells |
US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
US9499797B2 (en) | 2008-05-02 | 2016-11-22 | Kyoto University | Method of making induced pluripotent stem cells |
Also Published As
Publication number | Publication date |
---|---|
AU6339399A (en) | 2000-05-08 |
EP1129175A2 (en) | 2001-09-05 |
CA2346152A1 (en) | 2000-04-27 |
WO2000023567A2 (en) | 2000-04-27 |
JP2002527101A (en) | 2002-08-27 |
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