WO2000009108A3 - Compositions and uses for vision and memory disorders - Google Patents
Compositions and uses for vision and memory disorders Download PDFInfo
- Publication number
- WO2000009108A3 WO2000009108A3 PCT/US1999/018241 US9918241W WO0009108A3 WO 2000009108 A3 WO2000009108 A3 WO 2000009108A3 US 9918241 W US9918241 W US 9918241W WO 0009108 A3 WO0009108 A3 WO 0009108A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vision
- compositions
- memory disorders
- treating
- memory
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU55556/99A AU5555699A (en) | 1998-08-14 | 1999-08-12 | Compositions and uses for vision and memory disorders |
EP99942108A EP1105112A2 (en) | 1998-08-14 | 1999-08-12 | Compositions and uses for vision and memory disorders |
JP2000564611A JP4503180B2 (en) | 1998-08-14 | 1999-08-12 | Compositions and uses for vision and memory impairment |
CA002335815A CA2335815A1 (en) | 1998-08-14 | 1999-08-12 | Compositions and uses for vision and memory disorders |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13442298A | 1998-08-14 | 1998-08-14 | |
US09/134,422 | 1998-08-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000009108A2 WO2000009108A2 (en) | 2000-02-24 |
WO2000009108A3 true WO2000009108A3 (en) | 2000-05-18 |
Family
ID=22463332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/018241 WO2000009108A2 (en) | 1998-08-14 | 1999-08-12 | Compositions and uses for vision and memory disorders |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1105112A2 (en) |
JP (1) | JP4503180B2 (en) |
AU (1) | AU5555699A (en) |
CA (1) | CA2335815A1 (en) |
WO (1) | WO2000009108A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6218424B1 (en) * | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
AU6497200A (en) * | 1999-07-30 | 2001-02-19 | Vertex Pharmaceuticals Incorporated | Acyclic and cyclic amine derivatives |
ES2269206T3 (en) * | 1999-11-12 | 2007-04-01 | Alcon, Inc. | NEUROPHILINE LIGANDS TO TREAT EYE DISORDERS. |
CN1240691C (en) | 2001-12-06 | 2006-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | Substituted penta azacylo compounds and their use for preventing and treating nervous retrogression disease |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992000278A1 (en) * | 1990-07-02 | 1992-01-09 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
WO1992019593A1 (en) * | 1991-05-09 | 1992-11-12 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
WO1996040140A1 (en) * | 1995-06-07 | 1996-12-19 | Guilford Pharmaceuticals Inc. | Inhibitors of rotamase enzyme activity |
WO1996040633A1 (en) * | 1995-06-07 | 1996-12-19 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme activity |
WO1996041609A2 (en) * | 1995-06-08 | 1996-12-27 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
WO1997016190A1 (en) * | 1995-10-31 | 1997-05-09 | Guilford Pharmaceuticals Inc. | Rotamase enzyme activity inhibitors |
WO1997031020A1 (en) * | 1996-02-22 | 1997-08-28 | The General Hospital Corporation | METHODS AND COMPOSITIONS FOR ENHANCING CELLULAR RESPONSE TO TGF-β LIGANDS |
WO1998013343A1 (en) * | 1996-09-25 | 1998-04-02 | Guilford Pharmaceuticals Inc. | Heterocyclic thioesters and ketones |
WO1998013355A1 (en) * | 1996-09-25 | 1998-04-02 | Guilford Pharmaceuticals Inc. | Heterocyclic esters and amides |
WO1998037885A1 (en) * | 1997-02-28 | 1998-09-03 | Guilford Pharmaceuticals Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
WO1998048784A2 (en) * | 1997-04-28 | 1998-11-05 | The University Of British Columbia | Method and composition for modulating amyloidosis |
EP0947506A1 (en) * | 1998-03-24 | 1999-10-06 | Pfizer Products Inc. | 2-Aza-bicyclo[2.2.1]heptane derivatives and their use as rotamase inhibitors |
-
1999
- 1999-08-12 AU AU55556/99A patent/AU5555699A/en not_active Abandoned
- 1999-08-12 EP EP99942108A patent/EP1105112A2/en not_active Withdrawn
- 1999-08-12 WO PCT/US1999/018241 patent/WO2000009108A2/en not_active Application Discontinuation
- 1999-08-12 JP JP2000564611A patent/JP4503180B2/en not_active Expired - Fee Related
- 1999-08-12 CA CA002335815A patent/CA2335815A1/en not_active Abandoned
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992000278A1 (en) * | 1990-07-02 | 1992-01-09 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
WO1992019593A1 (en) * | 1991-05-09 | 1992-11-12 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
WO1996040140A1 (en) * | 1995-06-07 | 1996-12-19 | Guilford Pharmaceuticals Inc. | Inhibitors of rotamase enzyme activity |
WO1996040633A1 (en) * | 1995-06-07 | 1996-12-19 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme activity |
WO1996041609A2 (en) * | 1995-06-08 | 1996-12-27 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
WO1997016190A1 (en) * | 1995-10-31 | 1997-05-09 | Guilford Pharmaceuticals Inc. | Rotamase enzyme activity inhibitors |
WO1997031020A1 (en) * | 1996-02-22 | 1997-08-28 | The General Hospital Corporation | METHODS AND COMPOSITIONS FOR ENHANCING CELLULAR RESPONSE TO TGF-β LIGANDS |
WO1998013343A1 (en) * | 1996-09-25 | 1998-04-02 | Guilford Pharmaceuticals Inc. | Heterocyclic thioesters and ketones |
WO1998013355A1 (en) * | 1996-09-25 | 1998-04-02 | Guilford Pharmaceuticals Inc. | Heterocyclic esters and amides |
WO1998037885A1 (en) * | 1997-02-28 | 1998-09-03 | Guilford Pharmaceuticals Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
WO1998048784A2 (en) * | 1997-04-28 | 1998-11-05 | The University Of British Columbia | Method and composition for modulating amyloidosis |
EP0947506A1 (en) * | 1998-03-24 | 1999-10-06 | Pfizer Products Inc. | 2-Aza-bicyclo[2.2.1]heptane derivatives and their use as rotamase inhibitors |
Non-Patent Citations (5)
Title |
---|
H. GUO ET AL.: "The novel small molecule immunophilin ligand GPI 1046 stimulates cholinergic reinnervation of dearrerented hippocampal regions after fimbria-fornix transection", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 23, no. 1-2, 1997, pages 1729, XP000878535 * |
J.P. STEINER ET AL.: "Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models", PROC. NATL. ACAD. SCI., vol. 94, no. 5, 1997, pages 2019 - 2024, XP000876505 * |
PESSAH, I. N. (1): "Role for the major T-cell immunophilin FKBP12 in mediating neurotoxicity of non-coplanar PCBs.", NEUROTOXICOLOGY AND TERATOLOGY, (MAY-JUNE, 1998) VOL. 20, NO. 3, PP. 350. MEETING INFO.: TWENTY-SECOND ANNUAL MEETING OF THE NEUROBEHAVIORAL TERATOLOGY SOCIETY SAN DIEGO, CALIFORNIA, USA JUNE 20-24, 1998 NEUROBEHAVIORAL TERATOLOGY SOCIETY., XP000878599 * |
ROSS, D. T. ET AL: "The FKBP neuroimmunophilin ligand GPI - 1046 enhances retinal ganglion cell survival and arrests axonal dying back following optic nerve transection.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, (1998) VOL. 24, NO. 1-2, PP. 814. MEETING INFO.: 28TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, PART 1 LOS ANGELES, CALIFORNIA, USA NOVEMBER 7-12, 1998 SOCIETY FOR NEUROSCIENCE., XP000878539 * |
SAUER, H. ET AL: "Effects of chronic GPI - 1046 administration on spatial learning and memory in aged rodents.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, (1998) VOL. 24, NO. 1-2, PP. 686. MEETING INFO.: 28TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, PART 1 LOS ANGELES, CALIFORNIA, USA NOVEMBER 7-12, 1998 SOCIETY FOR NEUROSCIENCE., XP000878538 * |
Also Published As
Publication number | Publication date |
---|---|
CA2335815A1 (en) | 2000-02-24 |
AU5555699A (en) | 2000-03-06 |
EP1105112A2 (en) | 2001-06-13 |
JP4503180B2 (en) | 2010-07-14 |
WO2000009108A2 (en) | 2000-02-24 |
JP2002522484A (en) | 2002-07-23 |
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