WO2000004188A3 - Methods and compositions for comparing and normalizing assays - Google Patents

Methods and compositions for comparing and normalizing assays Download PDF

Info

Publication number
WO2000004188A3
WO2000004188A3 PCT/US1999/015836 US9915836W WO0004188A3 WO 2000004188 A3 WO2000004188 A3 WO 2000004188A3 US 9915836 W US9915836 W US 9915836W WO 0004188 A3 WO0004188 A3 WO 0004188A3
Authority
WO
WIPO (PCT)
Prior art keywords
comparing
assays
methods
compositions
normalizing
Prior art date
Application number
PCT/US1999/015836
Other languages
French (fr)
Other versions
WO2000004188A2 (en
Inventor
Joel Berger
Filippo Randazzo
Lewis T Williams
Original Assignee
Chiron Corp
Joel Berger
Filippo Randazzo
Lewis T Williams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, Joel Berger, Filippo Randazzo, Lewis T Williams filed Critical Chiron Corp
Priority to AU49911/99A priority Critical patent/AU4991199A/en
Publication of WO2000004188A2 publication Critical patent/WO2000004188A2/en
Publication of WO2000004188A3 publication Critical patent/WO2000004188A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention is directed to methods and compositions for comparing results from different assays or other measurement methods and converting between their results. More specifically, the present invention is drawn polynucleotide assays and comparing and quantifying results from two different assays or assay runs. The method includes using a standard comprising a plurality of polynucleotides.
PCT/US1999/015836 1998-07-15 1999-07-14 Methods and compositions for comparing and normalizing assays WO2000004188A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49911/99A AU4991199A (en) 1998-07-15 1999-07-14 Methods and compositions for comparing and normalizing assays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9284898P 1998-07-15 1998-07-15
US60/092,848 1998-07-15

Publications (2)

Publication Number Publication Date
WO2000004188A2 WO2000004188A2 (en) 2000-01-27
WO2000004188A3 true WO2000004188A3 (en) 2000-05-18

Family

ID=22235452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015836 WO2000004188A2 (en) 1998-07-15 1999-07-14 Methods and compositions for comparing and normalizing assays

Country Status (2)

Country Link
AU (1) AU4991199A (en)
WO (1) WO2000004188A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040058385A1 (en) * 2000-11-17 2004-03-25 Abel Andreas Peter Kit and method for determining multiple analytes, with provisions for refrencing the density of immobilised recognition elements
WO2003035865A1 (en) * 2001-10-22 2003-05-01 Takara Bio Inc. Method of labeling nucleic acids
US20040185451A1 (en) * 2003-03-21 2004-09-23 Leproust Eric M. Methods for detecting the presence of a nucleic acid analyte in a sample

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009156A1 (en) * 1992-10-08 1994-04-28 The Regents Of The University Of California Pcr assays to determine the presence and concentration of a target
WO1997010365A1 (en) * 1995-09-15 1997-03-20 Affymax Technologies N.V. Expression monitoring by hybridization to high density oligonucleotide arrays
WO1997027317A1 (en) * 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US5827648A (en) * 1995-12-13 1998-10-27 Chiron Corporation Differential hybridization for relative quantification of variant populations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
WO1994009156A1 (en) * 1992-10-08 1994-04-28 The Regents Of The University Of California Pcr assays to determine the presence and concentration of a target
WO1997010365A1 (en) * 1995-09-15 1997-03-20 Affymax Technologies N.V. Expression monitoring by hybridization to high density oligonucleotide arrays
US5827648A (en) * 1995-12-13 1998-10-27 Chiron Corporation Differential hybridization for relative quantification of variant populations
WO1997027317A1 (en) * 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
COLLINS M ET AL: "PREPARATION AND CHARACTERIZATION OF RNA STANDARDS FOR USE IN QUANTITATIVE BRANCHED DNS HYBRIDIZATION ASSAYS", ANALYTICAL BIOCHEMISTRY,US,ACADEMIC PRESS, SAN DIEGO, CA, vol. 226, no. 1, 20 March 1995 (1995-03-20), pages 120 - 129, XP000497066, ISSN: 0003-2697 *
MORRE S A ET AL: "RNA AMPLIFICATION BY NUCLEIC ACID SEQUENCE-BASED AMPLIFICATION WITHAN INTERNAL STANDARD ENABLES RELIABLE DETECTION OF CHLAMYDIA TRACHOMATIS IN CERVICAL SCRAPINGS AND URINE SAMPLES", JOURNAL OF CLINICAL MICROBIOLOGY,US,WASHINGTON, DC, vol. 34, no. 12, 1 December 1996 (1996-12-01), pages 3108 - 3114, XP000749295, ISSN: 0095-1137 *
PIETU G ET AL: "NOVEL GENE TRANSCRIPTS PREFERENTIALLY EXPRESSED IN HUMAN MUSCLES REVEALED BY QUANTITATIVE HYBRIDIZATION OF A HIGH DENSITY CDNA ARRAY", GENOME RESEARCH,US,COLD SPRING HARBOR LABORATORY PRESS, vol. 6, no. 6, 1 June 1996 (1996-06-01), pages 492 - 503, XP000597086, ISSN: 1088-9051 *
WANG S ET AL.: "Internal cRNA standards for quantitative northern analysis", BIOTECHNIQUES, vol. 14, no. 6, 1993, pages 935 - 941, XP002133186 *
ZARSKI J P ET AL.: "Comparison of a quantitative standardized HBV-DNA assay and a classical spot hybridization test in chronic active hepatitis B patients undergoing antiviral therapy", RESEARCH IN VIROLOGY, vol. 149, 1989, pages 283 - 291, XP000890113 *

Also Published As

Publication number Publication date
AU4991199A (en) 2000-02-07
WO2000004188A2 (en) 2000-01-27

Similar Documents

Publication Publication Date Title
WO2003020952A3 (en) Affinity-shifted probes for quantifying analyte polynucleotides
WO2003036256A3 (en) Method and apparatus for increasing the dynamic range and accuracy of binding assays
WO2003040395A3 (en) Universal nucleotides for nucleic acid analysis
WO2003042774A3 (en) Mass intensity profiling system and uses thereof
GB2330655A (en) Method and system for performing a binding assay
WO2003100012A3 (en) Microarrays and method for running hybridization reaction for multiple samples on a single microarray
NO881064L (en) PROCEDURE FOR DETERMINING NUCLEIC ACIDS BY HYBRIDIZATION TECHNIQUE, REAGENT COMBINATION AND TEST PACKAGE FOR CARRYING OUT THE PROCEDURE.
WO2000003038A3 (en) Method and reagents for analyzing the nucleotide sequence of nucleic acids
CA2163858A1 (en) Improved method and analytical system for performing fibrinogen assays accurately, rapidly and simply
WO2000058514A3 (en) Methods for improving sensitivity and specificity of screening assays
WO2001042496A3 (en) A method of assessing the amount of nucleic acid in a sample
WO2003036434A3 (en) A system and method for consensus-calling with per-base quality values for sample assemblies
GB2233450B (en) Detecting or quantifing multiple analytes with luminescent reagents
WO2002048404A3 (en) Method and kit for enhancing the association rates of polynucleotides
DE60143888D1 (en) METHOD TO INCREASE THE SENSITIVITY OF LUMINESIS ASSAY
CA2326791A1 (en) Hardness indicator composition and method of water hardness analysis
CA2204305A1 (en) Apparatus and method for determination of urine color
WO2000004188A3 (en) Methods and compositions for comparing and normalizing assays
WO2002013066A3 (en) Applying interpretations of chemical names
AU3775099A (en) Methods, kits and compositions for detecting and quantitating target sequences
FR2702060B1 (en) CRANK, ESPECIALLY WINCH OR CAPSTAN.
CA2095245A1 (en) Method of assay
WO2003067212A3 (en) Methods and reagents for conducting multiplexed assays of multiple analytes
WO1998026097A3 (en) NUCLEIC ACID PRIMERS AND PROBES FOR DETECTING $i(LEGIONELLA PNEUMOPHILA)
CA2377528A1 (en) Method and apparatus for presenting thrombosis and hemostasis assay data

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase