WO2000003994A3 - Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them - Google Patents

Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them Download PDF

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Publication number
WO2000003994A3
WO2000003994A3 PCT/EP1999/004886 EP9904886W WO0003994A3 WO 2000003994 A3 WO2000003994 A3 WO 2000003994A3 EP 9904886 W EP9904886 W EP 9904886W WO 0003994 A3 WO0003994 A3 WO 0003994A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
biphenylsulfonyl
preparation process
diagnostic agent
imidazole derivatives
Prior art date
Application number
PCT/EP1999/004886
Other languages
German (de)
French (fr)
Other versions
WO2000003994A2 (en
Inventor
Heinz-Werner Kleeman
Hans Jochen Lang
Jan-Robert Schwark
Andreas Weichert
Stefan Petry
Original Assignee
Aventis Pharma Gmbh
Kleeman Heinz Werner
Hans Jochen Lang
Schwark Jan Robert
Andreas Weichert
Stefan Petry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002338039A priority Critical patent/CA2338039A1/en
Priority to DE59908753T priority patent/DE59908753D1/en
Application filed by Aventis Pharma Gmbh, Kleeman Heinz Werner, Hans Jochen Lang, Schwark Jan Robert, Andreas Weichert, Stefan Petry filed Critical Aventis Pharma Gmbh
Priority to HU0103184A priority patent/HUP0103184A3/en
Priority to BR9912139-5A priority patent/BR9912139A/en
Priority to US09/743,941 priority patent/US6372917B1/en
Priority to JP2000560101A priority patent/JP4567884B2/en
Priority to EP99934669A priority patent/EP1097140B1/en
Priority to DK99934669T priority patent/DK1097140T3/en
Priority to PL99346165A priority patent/PL346165A1/en
Priority to KR1020017000751A priority patent/KR20010070984A/en
Priority to MXPA01000534A priority patent/MXPA01000534A/en
Priority to AU50364/99A priority patent/AU764784B2/en
Priority to AT99934669T priority patent/ATE260901T1/en
Publication of WO2000003994A2 publication Critical patent/WO2000003994A2/en
Publication of WO2000003994A3 publication Critical patent/WO2000003994A3/en
Priority to HK01109111A priority patent/HK1038352A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to compounds represented by formula (I), wherein the symbols have the meanings indicated in the description, which exhibit outstanding antiarrhythmic properties and comprise a cardioprotective component. The inventive compounds can preventively inhibit or strongly reduce pathophysiological processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
PCT/EP1999/004886 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them WO2000003994A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
PL99346165A PL346165A1 (en) 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them
DK99934669T DK1097140T3 (en) 1998-07-18 1999-07-10 Imidazole derivatives with biphenyl substitution, process for their preparation, their use as a drug or diagnostic and drug containing them
HU0103184A HUP0103184A3 (en) 1998-07-18 1999-07-10 Sulfonyl-biphenyl-methyl-substituted imidazole derivatives, their use and pharmaceutical compositions containing them
DE59908753T DE59908753D1 (en) 1998-07-18 1999-07-10 IMIDAZOLE DERIVATIVES WITH BIPHENYLSULFONYL SUBSTITUTION, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINE OR DIAGNOSTIC AND THE MEDICINE CONTAINING IT
US09/743,941 US6372917B1 (en) 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them
JP2000560101A JP4567884B2 (en) 1998-07-18 1999-07-10 Imidazole derivatives having a biphenylsulfonyl substitution, processes for their preparation, their use as medicaments or diagnostics, and medicaments containing them
KR1020017000751A KR20010070984A (en) 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them
CA002338039A CA2338039A1 (en) 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them
BR9912139-5A BR9912139A (en) 1998-07-18 1999-07-10 Imidazole derivatives with biphenylsulfonyl substitution process for its preparation its use as a medicine or diagnosis, as well as medicine containing it
EP99934669A EP1097140B1 (en) 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them
MXPA01000534A MXPA01000534A (en) 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them.
AU50364/99A AU764784B2 (en) 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them
AT99934669T ATE260901T1 (en) 1998-07-18 1999-07-10 IMIDAZOLE DERIVATIVES WITH BIPHENYLSULFONYL SUBSTITUTION, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION OR DIAGNOSTIC AND THE MEDICINAL CONTAINING THEM
HK01109111A HK1038352A1 (en) 1998-07-18 2001-12-27 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19832429.4 1998-07-18
DE19832429A DE19832429A1 (en) 1998-07-18 1998-07-18 New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction

Publications (2)

Publication Number Publication Date
WO2000003994A2 WO2000003994A2 (en) 2000-01-27
WO2000003994A3 true WO2000003994A3 (en) 2000-04-20

Family

ID=7874575

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/004886 WO2000003994A2 (en) 1998-07-18 1999-07-10 Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them

Country Status (23)

Country Link
US (1) US6372917B1 (en)
EP (1) EP1097140B1 (en)
JP (1) JP4567884B2 (en)
KR (1) KR20010070984A (en)
CN (1) CN1177827C (en)
AR (1) AR019404A1 (en)
AT (1) ATE260901T1 (en)
AU (1) AU764784B2 (en)
BR (1) BR9912139A (en)
CA (1) CA2338039A1 (en)
DE (2) DE19832429A1 (en)
DK (1) DK1097140T3 (en)
ES (1) ES2217779T3 (en)
HK (1) HK1038352A1 (en)
HU (1) HUP0103184A3 (en)
ID (1) ID27023A (en)
MX (1) MXPA01000534A (en)
PL (1) PL346165A1 (en)
PT (1) PT1097140E (en)
RU (1) RU2246489C2 (en)
TR (1) TR200100123T2 (en)
WO (1) WO2000003994A2 (en)
ZA (1) ZA200100318B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19832429A1 (en) 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction
DE19832428A1 (en) 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction
KR20030024259A (en) * 2001-09-17 2003-03-26 주식회사케이텍정보통신 Electronic toll collection system
US6844361B2 (en) * 2002-02-04 2005-01-18 Aventis Pharma Deutschland Gmbh Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor
US20030220383A1 (en) * 2002-02-14 2003-11-27 Aventis Pharma Deutschland Gmbh Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders
DE10206354A1 (en) * 2002-02-14 2003-08-28 Aventis Pharma Gmbh Use of inhibitors of the sodium-dependent chloride-bicarbonate exchanger for the treatment of thrombotic and inflammatory diseases
DE10356717A1 (en) * 2003-12-02 2005-07-07 Aventis Pharma Deutschland Gmbh Process for the preparation of (3-oxo-2,3-dihydro-1H-isoindol-1-yl) -acetylguanidine derivatives
US7531569B2 (en) * 2003-12-02 2009-05-12 Sanofi-Aventis Deutschland Gmbh Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0479479A1 (en) * 1990-10-01 1992-04-08 Merck & Co. Inc. Imadazole angiotensin II antagonists incorporating acidic functional groups
EP0503838A2 (en) * 1991-03-08 1992-09-16 Merck & Co. Inc. Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists
WO1992020662A1 (en) * 1991-05-10 1992-11-26 Merck & Co., Inc. Acidic aralkyl triazole derivatives active as angiotensin ii antagonists
WO1994003435A1 (en) * 1992-08-06 1994-02-17 E.I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists
US5391732A (en) * 1993-09-16 1995-02-21 Roussel-Uclaf Process for the preparation of biphenyl-imidazole derivatives
EP0648763A1 (en) * 1993-10-19 1995-04-19 Roussel Uclaf Process for the preparation of sulfur derivatives of imidazole and intermediates obtained
WO1995023791A1 (en) * 1994-03-04 1995-09-08 Roussel Uclaf Novel tetrasubstituted imidazole derivatives, method for preparing same, resulting novel intermediates, use thereof as drugs, and pharmaceutical compositions containing same
US5482957A (en) * 1991-01-04 1996-01-09 Hoechst Aktiengesellschaft Azole derivatives, process for their preparation and their use
US5604251A (en) * 1992-03-07 1997-02-18 Hoechst Aktiengesellschaft Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors
EP0855392A2 (en) * 1997-01-22 1998-07-29 Hoechst Aktiengesellschaft Five-membered heterocycles having biphenylsulphonyl substituents, processes for the preparation thereof, their use as medicaments or diagnostic agent and medicaments containing them

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2716882B1 (en) 1994-03-04 1996-04-05 Roussel Uclaf Use of imidazole derivatives for the treatment of conditions involving the AT1 and AT2 receptors of Angiotensin, some of these products, their preparation, pharmaceutical compositions.
DE19540995A1 (en) * 1995-11-03 1997-05-07 Hoechst Ag Substituted sulfonimidamides, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE19832428A1 (en) 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction
DE19832429A1 (en) 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh New imidazolylmethyl-biphenyl-sulfonylcyanamides, are sodium-dependent bicarbonate/chloride exchanger inhibitors used e.g. for treating cardiovascular disorders such as cardiac infarction

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0479479A1 (en) * 1990-10-01 1992-04-08 Merck & Co. Inc. Imadazole angiotensin II antagonists incorporating acidic functional groups
US5482957A (en) * 1991-01-04 1996-01-09 Hoechst Aktiengesellschaft Azole derivatives, process for their preparation and their use
EP0503838A2 (en) * 1991-03-08 1992-09-16 Merck & Co. Inc. Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists
WO1992020662A1 (en) * 1991-05-10 1992-11-26 Merck & Co., Inc. Acidic aralkyl triazole derivatives active as angiotensin ii antagonists
US5604251A (en) * 1992-03-07 1997-02-18 Hoechst Aktiengesellschaft Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors
WO1994003435A1 (en) * 1992-08-06 1994-02-17 E.I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists
US5391732A (en) * 1993-09-16 1995-02-21 Roussel-Uclaf Process for the preparation of biphenyl-imidazole derivatives
EP0648763A1 (en) * 1993-10-19 1995-04-19 Roussel Uclaf Process for the preparation of sulfur derivatives of imidazole and intermediates obtained
WO1995023791A1 (en) * 1994-03-04 1995-09-08 Roussel Uclaf Novel tetrasubstituted imidazole derivatives, method for preparing same, resulting novel intermediates, use thereof as drugs, and pharmaceutical compositions containing same
EP0855392A2 (en) * 1997-01-22 1998-07-29 Hoechst Aktiengesellschaft Five-membered heterocycles having biphenylsulphonyl substituents, processes for the preparation thereof, their use as medicaments or diagnostic agent and medicaments containing them

Also Published As

Publication number Publication date
CA2338039A1 (en) 2000-01-27
HUP0103184A2 (en) 2002-04-29
BR9912139A (en) 2001-04-10
DE59908753D1 (en) 2004-04-08
ZA200100318B (en) 2002-04-11
CN1309644A (en) 2001-08-22
AU5036499A (en) 2000-02-07
MXPA01000534A (en) 2002-06-04
US6372917B1 (en) 2002-04-16
PL346165A1 (en) 2002-01-28
DK1097140T3 (en) 2004-05-24
ATE260901T1 (en) 2004-03-15
CN1177827C (en) 2004-12-01
AR019404A1 (en) 2002-02-20
EP1097140B1 (en) 2004-03-03
ID27023A (en) 2001-02-22
JP2002520397A (en) 2002-07-09
PT1097140E (en) 2004-07-30
DE19832429A1 (en) 2000-01-20
HUP0103184A3 (en) 2002-05-28
RU2246489C2 (en) 2005-02-20
HK1038352A1 (en) 2002-03-15
WO2000003994A2 (en) 2000-01-27
JP4567884B2 (en) 2010-10-20
AU764784B2 (en) 2003-08-28
KR20010070984A (en) 2001-07-28
TR200100123T2 (en) 2001-05-21
EP1097140A2 (en) 2001-05-09
ES2217779T3 (en) 2004-11-01

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