WO2000002522A3 - Anthrax vaccine - Google Patents

Anthrax vaccine Download PDF

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Publication number
WO2000002522A3
WO2000002522A3 PCT/US1999/015568 US9915568W WO0002522A3 WO 2000002522 A3 WO2000002522 A3 WO 2000002522A3 US 9915568 W US9915568 W US 9915568W WO 0002522 A3 WO0002522 A3 WO 0002522A3
Authority
WO
WIPO (PCT)
Prior art keywords
anthrax vaccine
anthrax
vaccine
anthracis
subjects
Prior art date
Application number
PCT/US1999/015568
Other languages
French (fr)
Other versions
WO2000002522A9 (en
WO2000002522A2 (en
Inventor
John S Lee
Peter Pushko
Michael D Parker
Jonathan F Smith
Susan L Welkos
Original Assignee
Us Med Res Inst Infect Disease
John S Lee
Peter Pushko
Michael D Parker
Jonathan F Smith
Susan L Welkos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Med Res Inst Infect Disease, John S Lee, Peter Pushko, Michael D Parker, Jonathan F Smith, Susan L Welkos filed Critical Us Med Res Inst Infect Disease
Priority to EP99941953A priority Critical patent/EP1097212B1/en
Priority to DE69940157T priority patent/DE69940157D1/en
Priority to CA002339355A priority patent/CA2339355A1/en
Priority to AU55426/99A priority patent/AU758019B2/en
Publication of WO2000002522A2 publication Critical patent/WO2000002522A2/en
Publication of WO2000002522A3 publication Critical patent/WO2000002522A3/en
Publication of WO2000002522A9 publication Critical patent/WO2000002522A9/en

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Using the nontoxic protective antigen PA protein from B. anthracis, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.
PCT/US1999/015568 1998-07-10 1999-07-09 Anthrax vaccine WO2000002522A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99941953A EP1097212B1 (en) 1998-07-10 1999-07-09 Anthrax vaccine
DE69940157T DE69940157D1 (en) 1998-07-10 1999-07-09 Anthrax-impfstoff
CA002339355A CA2339355A1 (en) 1998-07-10 1999-07-09 Anthrax vaccine
AU55426/99A AU758019B2 (en) 1998-07-10 1999-07-09 Anthrax vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9241698P 1998-07-10 1998-07-10
US60/092,416 1998-07-10

Publications (3)

Publication Number Publication Date
WO2000002522A2 WO2000002522A2 (en) 2000-01-20
WO2000002522A3 true WO2000002522A3 (en) 2000-10-12
WO2000002522A9 WO2000002522A9 (en) 2001-04-05

Family

ID=22233100

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1999/015568 WO2000002522A2 (en) 1998-07-10 1999-07-09 Anthrax vaccine
PCT/US1999/015569 WO2000002523A2 (en) 1998-07-10 1999-07-09 Vaccine against staphylococcus intoxication

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015569 WO2000002523A2 (en) 1998-07-10 1999-07-09 Vaccine against staphylococcus intoxication

Country Status (7)

Country Link
US (2) US6632640B1 (en)
EP (2) EP1097213B1 (en)
AT (2) ATE418612T1 (en)
AU (2) AU761021B2 (en)
CA (2) CA2339355A1 (en)
DE (2) DE69940157D1 (en)
WO (2) WO2000002522A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906119B1 (en) 2002-06-26 2011-03-15 Human Genome Sciences, Inc. Antibodies against protective antigen

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US7087235B2 (en) * 1997-06-25 2006-08-08 The United States Of America As Represented By The Secretary Of The Army Fusion protein of streptococcal pyrogenic exotoxins
ATE418612T1 (en) * 1998-07-10 2009-01-15 U S Medical Res Inst Of Infect ANTHRAX VACCINE
MXPA01001631A (en) * 1998-08-13 2002-04-08 Walter Reed Army Inst Of Res D Bacterial superantigen vaccines.
WO2000062856A1 (en) 1999-04-16 2000-10-26 Johnson & Johnson Consumer Companies, Inc. Drug delivery device comprising a dual chamber reservoir
US6783939B2 (en) * 2000-07-07 2004-08-31 Alphavax, Inc. Alphavirus vectors and virosomes with modified HIV genes for use in vaccines
GB0016702D0 (en) 2000-07-08 2000-08-23 Secr Defence Brit Expression system
SE0102327D0 (en) * 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy
GB0118009D0 (en) * 2001-07-24 2001-09-19 Regma Biotechnologies Ltd Novel preparation
CA2460269C (en) * 2001-09-06 2013-01-15 Alphavax, Inc. Alphavirus replicon vector systems
JP2005511059A (en) 2001-12-05 2005-04-28 バートナガー ラケシュ Process for the preparation of non-toxic anthrax vaccine
WO2003087378A1 (en) * 2002-04-11 2003-10-23 Powderject Research Limited Nucleic acid immunization
US20070105799A1 (en) * 2002-09-10 2007-05-10 Vical Incorporated Codon-optimized polynucleotide-based vaccines against Bacillus anthracis infection
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
JP4991108B2 (en) * 2002-12-13 2012-08-01 アルファバックス，インコーポレイティド Multi-antigenic alphavirus replicon particles and methods
KR101518309B1 (en) * 2003-03-20 2015-05-08 알파벡스, 인크. Improved alphavirus replicons and helper constructs
WO2005034841A2 (en) * 2003-05-14 2005-04-21 Merck & Co., Inc. Anthrax vaccine
AU2004257214B2 (en) * 2003-07-11 2010-04-22 Alphavax, Inc. Alphavirus-based cytomegalovirus vaccines
WO2005026203A2 (en) 2003-09-18 2005-03-24 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dna promoters and anthrax vaccines
US8409590B2 (en) 2004-02-11 2013-04-02 Ligocyte Pharmaceuticals, Inc. Anthrax antigens and methods of use
US20080095777A1 (en) 2004-09-22 2008-04-24 Glaxosmithkline Biologicals S.A. Immunogenic Composition for Use in Vaccination Against Staphylococcei
BRPI0609362A2 (en) * 2005-04-11 2010-03-30 Us Gov Health & Human Serv recombinant adenovirus vector, recombinant adenovirus, immunogenic composition and method for producing said immunogenic composition
CN101242856A (en) 2005-09-09 2008-08-13 莱博法姆公司 Sustained drug release compositions
JP2009531387A (en) 2006-03-30 2009-09-03 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Immunogenic composition
US20070248960A1 (en) * 2006-04-19 2007-10-25 Rees Dianne M Arrays containing cleavable RNAi molecules
US7850977B2 (en) * 2007-06-21 2010-12-14 Alphavax, Inc. Promoterless cassettes for expression of alphavirus structural proteins
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
CA2697538C (en) 2007-08-31 2019-02-12 University Of Chicago Methods and compositions related to immunizing against staphylococcal lung diseases and conditions
WO2009063507A1 (en) * 2007-11-12 2009-05-22 Rakesh Bhatnagar Dna vaccine against anthrax
US8758765B2 (en) 2008-07-29 2014-06-24 The University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
EP2341929B1 (en) 2008-10-06 2017-01-25 University Of Chicago Compositions and methods related to bacterial emp proteins
WO2011005341A2 (en) 2009-04-03 2011-01-13 University Of Chicago Compositions and methods related to protein a (spa) variants
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
EP2555794A4 (en) 2010-04-05 2014-01-15 Univ Chicago COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SpA) ANTIBODIES AS AN ENHANCER OF IMMUNE RESPONSE
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EP2614074A1 (en) 2010-09-09 2013-07-17 The University of Chicago Methods and compositions involving protective staphylococcal antigens
CA2830415A1 (en) * 2011-03-16 2012-12-13 Regents Of The University Of Minnesota Compositions and methods for inducing immune responses against bacteria in the genus staphylococcus
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
CN103906535B (en) 2011-08-15 2017-07-14 芝加哥大学 The composition related to the antibody of staphylococcal protein A and method
JP6670106B2 (en) 2012-04-26 2020-03-18 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ Staphylococcal coagulase antigen and method of use
JP6251730B2 (en) 2012-04-26 2017-12-20 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ Compositions and methods related to antibodies that neutralize coagulase activity during STAPHYLOCOCUSAUREUS disease
WO2014205111A1 (en) 2013-06-19 2014-12-24 Integrated Biotherapeutics, Inc. Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof
US10314910B2 (en) 2016-01-10 2019-06-11 Neotx Therapeutics Ltd. Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy
US11505722B2 (en) * 2017-06-30 2022-11-22 The Boeing Company Nonaqueous sol-gel for adhesion enhancement of water-sensitive materials
JP7303791B2 (en) 2017-07-27 2023-07-05 アブヴァク インコーポレイテッド Immunogenic compositions containing fusion peptides derived from superantigen toxoids
KR20220009428A (en) 2019-05-15 2022-01-24 네오티엑스 테라퓨틱스 엘티디. cancer treatment
BR112022005615A2 (en) 2019-10-02 2022-07-12 Janssen Vaccines & Prevention Bv STAPHYLOCOCCUS PEPTIDES AND METHODS OF USE
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906119B1 (en) 2002-06-26 2011-03-15 Human Genome Sciences, Inc. Antibodies against protective antigen

Also Published As

Publication number Publication date
CA2337966A1 (en) 2000-01-20
DE69940157D1 (en) 2009-02-05
DE69941454D1 (en) 2009-11-05
US20040009183A1 (en) 2004-01-15
CA2339355A1 (en) 2000-01-20
WO2000002523A2 (en) 2000-01-20
EP1097213B1 (en) 2009-09-23
ATE443768T1 (en) 2009-10-15
WO2000002523A3 (en) 2000-11-23
WO2000002522A9 (en) 2001-04-05
AU5667399A (en) 2000-02-01
US7374931B2 (en) 2008-05-20
AU758019B2 (en) 2003-03-13
EP1097212A2 (en) 2001-05-09
AU5542699A (en) 2000-02-01
ATE418612T1 (en) 2009-01-15
WO2000002523A9 (en) 2000-07-27
AU761021B2 (en) 2003-05-29
US6632640B1 (en) 2003-10-14
WO2000002522A2 (en) 2000-01-20
EP1097212B1 (en) 2008-12-24
EP1097213A2 (en) 2001-05-09

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