WO2000000158A3 - Alkylamines and their precursors as specific modulators of human gamma-delta t cell function - Google Patents

Alkylamines and their precursors as specific modulators of human gamma-delta t cell function Download PDF

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Publication number
WO2000000158A3
WO2000000158A3 PCT/US1999/014303 US9914303W WO0000158A3 WO 2000000158 A3 WO2000000158 A3 WO 2000000158A3 US 9914303 W US9914303 W US 9914303W WO 0000158 A3 WO0000158 A3 WO 0000158A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkylamines
precursors
delta
cell function
human gamma
Prior art date
Application number
PCT/US1999/014303
Other languages
French (fr)
Other versions
WO2000000158A2 (en
WO2000000158A9 (en
Inventor
Jack F Bukowski
Michael B Brenner
Original Assignee
Brigham & Womens Hospital
Jack F Bukowski
Michael B Brenner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Jack F Bukowski, Michael B Brenner filed Critical Brigham & Womens Hospital
Priority to CA002335791A priority Critical patent/CA2335791A1/en
Priority to JP2000556744A priority patent/JP2002519007A/en
Priority to AU52059/99A priority patent/AU5205999A/en
Priority to EP99937178A priority patent/EP1090106A2/en
Publication of WO2000000158A2 publication Critical patent/WO2000000158A2/en
Publication of WO2000000158A9 publication Critical patent/WO2000000158A9/en
Publication of WO2000000158A3 publication Critical patent/WO2000000158A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Methods and compositions for inducing the proliferation of Vη2Vδ2 T cells are provided. The compositions contain alkyklamine agents, such as alkylamines and alkylamine precursors. The agents also are useful for activating the ηδ T cell receptor.
PCT/US1999/014303 1998-06-30 1999-06-24 Alkylamines and their precursors as specific modulators of human gamma-delta t cell function WO2000000158A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002335791A CA2335791A1 (en) 1998-06-30 1999-06-24 Alkylamines and their precursors as specific modulators of human gamma-delta t cell function
JP2000556744A JP2002519007A (en) 1998-06-30 1999-06-24 Alkylamines and their precursors as specific modulators of human gamma-delta T cell function
AU52059/99A AU5205999A (en) 1998-06-30 1999-06-24 Alkylamines and their precursors as specific modulators of human gamma-delta t cell function
EP99937178A EP1090106A2 (en) 1998-06-30 1999-06-24 Alkylamines and their precursors as specific modulators of human gamma-delta t cell function

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9119798P 1998-06-30 1998-06-30
US60/091,197 1998-06-30

Publications (3)

Publication Number Publication Date
WO2000000158A2 WO2000000158A2 (en) 2000-01-06
WO2000000158A9 WO2000000158A9 (en) 2000-06-22
WO2000000158A3 true WO2000000158A3 (en) 2000-11-16

Family

ID=22226564

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/014303 WO2000000158A2 (en) 1998-06-30 1999-06-24 Alkylamines and their precursors as specific modulators of human gamma-delta t cell function

Country Status (5)

Country Link
EP (1) EP1090106A2 (en)
JP (1) JP2002519007A (en)
AU (1) AU5205999A (en)
CA (1) CA2335791A1 (en)
WO (1) WO2000000158A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003245835A1 (en) * 2002-02-18 2003-09-04 Ajinomoto Co., Inc. Novel preventive for infections
US7767714B2 (en) 2002-02-18 2010-08-03 Ajinomoto Co., Inc. Method of preventing infectious diseases
ATE441420T1 (en) * 2002-12-02 2009-09-15 Innate Pharma COMPOSITIONS CONTAINING INTERLEUKIN-2 AND GAMMA DELTA T CELL ACTIVATOR AND USES THEREOF
EP1767200A4 (en) * 2004-06-15 2007-08-15 Osaka Prefecture Antiaging agent

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574859A (en) * 1968-07-05 1971-04-13 Carl M Kosti Process for the treatment of hypertrophied gums
US4153679A (en) * 1972-04-18 1979-05-08 Wilkinson Sword Limited Acyclic carboxamides having a physiological cooling effect
US4242359A (en) * 1977-04-01 1980-12-30 Cornell Research Foundation, Inc. Spermicidal agents
US5601822A (en) * 1986-07-03 1997-02-11 T Cell Sciences, Inc. γ, δ T cell receptor and methods for detection
US5639653A (en) * 1993-07-19 1997-06-17 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy Method for proliferating Vγ2Vδ2 T cells
US5679347A (en) * 1992-12-10 1997-10-21 Brigham And Women's Hospital Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574859A (en) * 1968-07-05 1971-04-13 Carl M Kosti Process for the treatment of hypertrophied gums
US4153679A (en) * 1972-04-18 1979-05-08 Wilkinson Sword Limited Acyclic carboxamides having a physiological cooling effect
US4242359A (en) * 1977-04-01 1980-12-30 Cornell Research Foundation, Inc. Spermicidal agents
US5601822A (en) * 1986-07-03 1997-02-11 T Cell Sciences, Inc. γ, δ T cell receptor and methods for detection
US5679347A (en) * 1992-12-10 1997-10-21 Brigham And Women's Hospital Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
US5639653A (en) * 1993-07-19 1997-06-17 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy Method for proliferating Vγ2Vδ2 T cells
US5902793A (en) * 1993-07-19 1999-05-11 Albert Einstein College Of Medicine Of Yeshiva University Method for proliferating Vγ2Vδ2 T cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BUDAVARI S.: "MERCK INDEX. ENCYCLOPEDIA OF CHEMICALS, DRUGS, AND BIOLOGICALS.", vol. ED. 11, 1 January 1989, RAHWAY, MERCK & CO., US, article "THE MERCK INDEX AN ENCYCLOPEDIA OF CHEMICALS, DRUGS AND BIOLOGICALS", pages: 5943/5944, XP002931120, 019997 *
MCMURRY J: "ORGANIC CHEMISTRY", ORGANIC CHEMISTRY, XX, XX, no. 02, 1 January 1988 (1988-01-01), XX, pages 738 - 740, XP002931119 *

Also Published As

Publication number Publication date
WO2000000158A2 (en) 2000-01-06
CA2335791A1 (en) 2000-01-06
WO2000000158A9 (en) 2000-06-22
JP2002519007A (en) 2002-07-02
EP1090106A2 (en) 2001-04-11
AU5205999A (en) 2000-01-17

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