WO1999064408A8 - Promedicaments a base d'antagoniste d'oestrogene - Google Patents

Promedicaments a base d'antagoniste d'oestrogene

Info

Publication number
WO1999064408A8
WO1999064408A8 PCT/JP1999/003117 JP9903117W WO9964408A8 WO 1999064408 A8 WO1999064408 A8 WO 1999064408A8 JP 9903117 W JP9903117 W JP 9903117W WO 9964408 A8 WO9964408 A8 WO 9964408A8
Authority
WO
WIPO (PCT)
Prior art keywords
prodrugs
estrogen antagonist
hydrogen
integer
general formula
Prior art date
Application number
PCT/JP1999/003117
Other languages
English (en)
Japanese (ja)
Other versions
WO1999064408A1 (fr
Inventor
Akira Okamachi
Takahiro Hatanaka
Kiyohiko Sugano
Yoshiki Hayashi
Original Assignee
C & C Research Lab
Akira Okamachi
Takahiro Hatanaka
Kiyohiko Sugano
Yoshiki Hayashi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C & C Research Lab, Akira Okamachi, Takahiro Hatanaka, Kiyohiko Sugano, Yoshiki Hayashi filed Critical C & C Research Lab
Priority to AU41652/99A priority Critical patent/AU4165299A/en
Publication of WO1999064408A1 publication Critical patent/WO1999064408A1/fr
Publication of WO1999064408A8 publication Critical patent/WO1999064408A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne des composés de la formule générale (I) ou leurs sels pharmaceutiquement acceptables. Dans cette formule, ------ désigne une liaison simple ou double; R1 et R2 désignent chacun indépendamment hydrogène, alkyle inférieur, aralkyle, alkényle, alkinyle, acyle ou similaire, à l'exception des cas où R1 et R2 désignent à la fois simultanément hydrogène ou alkyle inférieur; R3 désigne hydrogène ou méthyle; X désigne O ou S; et A désigne un groupe représenté par ex. par la formule générale (a): -(CH2)m-(NH)nS(O)p(NH)q-R4 dans laquelle R4 désigne alkyle ou haloalkyle; m désigne un nombre entier compris entre 3 et 10; n vaut 0 ou 1; p vaut 0, 1 ou 2; q vaut 0 ou 1; et r désigne un nombre entier compris entre 1 et 6.
PCT/JP1999/003117 1998-06-12 1999-06-11 Promedicaments a base d'antagoniste d'oestrogene WO1999064408A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41652/99A AU4165299A (en) 1998-06-12 1999-06-11 Prodrugs of estrogen antagonist

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16563898 1998-06-12
JP10/165638 1998-06-12

Publications (2)

Publication Number Publication Date
WO1999064408A1 WO1999064408A1 (fr) 1999-12-16
WO1999064408A8 true WO1999064408A8 (fr) 2000-03-09

Family

ID=15816172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/003117 WO1999064408A1 (fr) 1998-06-12 1999-06-11 Promedicaments a base d'antagoniste d'oestrogene

Country Status (3)

Country Link
KR (1) KR20010052673A (fr)
AU (1) AU4165299A (fr)
WO (1) WO1999064408A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000001793A (ko) * 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
ES2185054T3 (es) * 1996-12-13 2003-04-16 Chugai Pharmaceutical Co Ltd Derivados de benzopirano.

Also Published As

Publication number Publication date
AU4165299A (en) 1999-12-30
WO1999064408A1 (fr) 1999-12-16
KR20010052673A (ko) 2001-06-25

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