WO1999053031A3 - Process for producing cell clone libraries - Google Patents
Process for producing cell clone libraries Download PDFInfo
- Publication number
- WO1999053031A3 WO1999053031A3 PCT/EP1999/002391 EP9902391W WO9953031A3 WO 1999053031 A3 WO1999053031 A3 WO 1999053031A3 EP 9902391 W EP9902391 W EP 9902391W WO 9953031 A3 WO9953031 A3 WO 9953031A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cell clone
- producing cell
- clone libraries
- cell
- cell clones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU37070/99A AU3707099A (en) | 1998-04-08 | 1999-04-08 | Process for producing cell clone libraries |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19815590.5 | 1998-04-08 | ||
DE19815590 | 1998-04-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999053031A2 WO1999053031A2 (en) | 1999-10-21 |
WO1999053031A3 true WO1999053031A3 (en) | 1999-12-16 |
Family
ID=7863891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/002391 WO1999053031A2 (en) | 1998-04-08 | 1999-04-08 | Process for producing cell clone libraries |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU3707099A (en) |
WO (1) | WO1999053031A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6787646B1 (en) * | 1999-11-12 | 2004-09-07 | Immusol, Inc. | Tumor suppressor molecules and methods of use |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011230A1 (en) * | 1991-12-02 | 1993-06-10 | Dynal As | Modified mammalian stem cell blocking viral replication |
WO1994013833A1 (en) * | 1992-12-04 | 1994-06-23 | Innovir Laboratories, Inc. | Ribozyme amplified diagnostics |
DE4424762C1 (en) * | 1994-07-04 | 1995-07-27 | Max Planck Gesellschaft | Ribozyme library in optimised expression cassette |
WO1997027213A1 (en) * | 1996-01-23 | 1997-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening for transdominant effector peptides and rna molecules |
WO1998032880A1 (en) * | 1997-01-23 | 1998-07-30 | Immusol Incorporated | Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries |
-
1999
- 1999-04-08 WO PCT/EP1999/002391 patent/WO1999053031A2/en active Application Filing
- 1999-04-08 AU AU37070/99A patent/AU3707099A/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011230A1 (en) * | 1991-12-02 | 1993-06-10 | Dynal As | Modified mammalian stem cell blocking viral replication |
WO1994013833A1 (en) * | 1992-12-04 | 1994-06-23 | Innovir Laboratories, Inc. | Ribozyme amplified diagnostics |
DE4424762C1 (en) * | 1994-07-04 | 1995-07-27 | Max Planck Gesellschaft | Ribozyme library in optimised expression cassette |
WO1997027213A1 (en) * | 1996-01-23 | 1997-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening for transdominant effector peptides and rna molecules |
WO1998032880A1 (en) * | 1997-01-23 | 1998-07-30 | Immusol Incorporated | Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries |
Non-Patent Citations (5)
Title |
---|
HASELOFF J ET AL: "SIMPLE RNA ENZYMES WITH NEW AND HIGHLY SPECIFIC ENDORIBONUCLEASE ACTIVITIES", NATURE, vol. 334, 18 August 1988 (1988-08-18), pages 585 - 591, XP002029776, ISSN: 0028-0836 * |
JARVIS T C ET AL: "INHIBITION OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATION BY HAMMERHEAD RIBOZYMES TARGETTING C-MYB", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 19A, 1 January 1995 (1995-01-01), pages 221, XP002024063, ISSN: 0730-2312 * |
LARSSON S ET AL.,: "Reduced beta2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme", NUCLEIC ACIDS RESEARCH, vol. 22, no. 12, 1994, pages 2242 - 2248, XP002120162 * |
SKRYABIN BV AND SCHMAUSS C: "Enhanced selection fro homologous-recombinant embryonic stem cell clones with a neomycin phosphotransferase gene in antisense orientation", TRANSGENIC RESEARCH, vol. 6, 1997, pages 27 - 35, XP002120163 * |
XIE Y F ET AL: "A ribozyme -mediated, gene ''knockdown'' strategy for the identification of gene function in zebrafish", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, no. 25, 9 December 1997 (1997-12-09), pages 13777 - 13781, XP002108912, ISSN: 0027-8424 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999053031A2 (en) | 1999-10-21 |
AU3707099A (en) | 1999-11-01 |
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