WO1999045905A3 - Prophylaxis and treatment of migraine headaches with thromboxane synthetase inhibitors and/or receptor antagonists - Google Patents

Prophylaxis and treatment of migraine headaches with thromboxane synthetase inhibitors and/or receptor antagonists Download PDF

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Publication number
WO1999045905A3
WO1999045905A3 PCT/US1999/004650 US9904650W WO9945905A3 WO 1999045905 A3 WO1999045905 A3 WO 1999045905A3 US 9904650 W US9904650 W US 9904650W WO 9945905 A3 WO9945905 A3 WO 9945905A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonists
synthetase inhibitors
prophylaxis
treatment
thromboxane
Prior art date
Application number
PCT/US1999/004650
Other languages
French (fr)
Other versions
WO1999045905A2 (en
Inventor
John R Plachetka
Original Assignee
Pozen Inc
John R Plachetka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pozen Inc, John R Plachetka filed Critical Pozen Inc
Priority to AU28908/99A priority Critical patent/AU2890899A/en
Publication of WO1999045905A2 publication Critical patent/WO1999045905A2/en
Publication of WO1999045905A3 publication Critical patent/WO1999045905A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine

Abstract

The use of thromboxane receptor antagonists and/or thromboxane synthetase inhibitors in the prophylaxis and treatment of migraine is described. Further described are the use of thromboxane receptor antagonists and/or thromboxane synthetase inhibitors together with known migraine palliatives such as 5-HT1 agonists, non-steroidal anti-inflammatory agents, and the like. Pharmaceutical compositions are described containing both known migraine palliatives and thromboxane receptor antagonists and/or thromboxane synthetase inhibitors.
PCT/US1999/004650 1998-03-13 1999-03-11 Prophylaxis and treatment of migraine headaches with thromboxane synthetase inhibitors and/or receptor antagonists WO1999045905A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28908/99A AU2890899A (en) 1998-03-13 1999-03-11 Prophylaxis and treatment of migraine headaches with thromboxane synthetase inhibitors and/or receptor antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7800198P 1998-03-13 1998-03-13
US60/078,001 1998-03-13

Publications (2)

Publication Number Publication Date
WO1999045905A2 WO1999045905A2 (en) 1999-09-16
WO1999045905A3 true WO1999045905A3 (en) 1999-10-21

Family

ID=22141292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004650 WO1999045905A2 (en) 1998-03-13 1999-03-11 Prophylaxis and treatment of migraine headaches with thromboxane synthetase inhibitors and/or receptor antagonists

Country Status (2)

Country Link
AU (1) AU2890899A (en)
WO (1) WO1999045905A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
WO2001089519A1 (en) * 2000-05-22 2001-11-29 Nitromed, Inc. Thromboxane inhibitors, compositions and methods of use related applications
JP4616009B2 (en) 2002-12-26 2011-01-19 ポーゼン インコーポレイテッド Multi-layer dosage form containing NSAIDs and triptan
CA2534316A1 (en) * 2003-08-07 2005-02-24 B.M.R.A. Corporation B.V. Compositions and methods involving the combination of a thromboxane a2 receptor antagonist and an inhibitor of cyclooxygenase-1

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2038821A (en) * 1978-12-13 1980-07-30 Pfizer Ltd N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme pharmaceutical compositions thereof and process for their preparation
WO1991013062A2 (en) * 1990-02-27 1991-09-05 Farmitalia Carlo Erba S.R.L. Substituted 1-(alkoxy-iminoalkyl)imidazole derivatives
WO1992002494A1 (en) * 1990-07-27 1992-02-20 Schering Aktiengesellschaft Berlin/Bergkamen Cyclopentane derivatives, process for producing them and their pharmaceutical use
WO1992019182A2 (en) * 1991-04-24 1992-11-12 Board Of Regents, The University Of Texas System Method of attenuation of neointimal proliferation
WO1992019270A1 (en) * 1991-05-02 1992-11-12 Kirchengast, Michael Novel combination of medicaments
US5605917A (en) * 1994-12-22 1997-02-25 Bristol-Myers Squibb Company Method of treating dysmenorrhea employing an interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analog

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2038821A (en) * 1978-12-13 1980-07-30 Pfizer Ltd N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme pharmaceutical compositions thereof and process for their preparation
WO1991013062A2 (en) * 1990-02-27 1991-09-05 Farmitalia Carlo Erba S.R.L. Substituted 1-(alkoxy-iminoalkyl)imidazole derivatives
WO1992002494A1 (en) * 1990-07-27 1992-02-20 Schering Aktiengesellschaft Berlin/Bergkamen Cyclopentane derivatives, process for producing them and their pharmaceutical use
WO1992019182A2 (en) * 1991-04-24 1992-11-12 Board Of Regents, The University Of Texas System Method of attenuation of neointimal proliferation
WO1992019270A1 (en) * 1991-05-02 1992-11-12 Kirchengast, Michael Novel combination of medicaments
US5605917A (en) * 1994-12-22 1997-02-25 Bristol-Myers Squibb Company Method of treating dysmenorrhea employing an interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analog

Also Published As

Publication number Publication date
AU2890899A (en) 1999-09-27
WO1999045905A2 (en) 1999-09-16

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