WO1999044718A1 - Dispositif permettant de filtrer et de recueillir du sang ou des produits sanguins et technique afferente - Google Patents

Dispositif permettant de filtrer et de recueillir du sang ou des produits sanguins et technique afferente Download PDF

Info

Publication number
WO1999044718A1
WO1999044718A1 PCT/US1999/004544 US9904544W WO9944718A1 WO 1999044718 A1 WO1999044718 A1 WO 1999044718A1 US 9904544 W US9904544 W US 9904544W WO 9944718 A1 WO9944718 A1 WO 9944718A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
tubing
length
product
blood product
Prior art date
Application number
PCT/US1999/004544
Other languages
English (en)
Other versions
WO1999044718A8 (fr
Inventor
James L. O'connor
Original Assignee
Hemasure Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemasure Inc. filed Critical Hemasure Inc.
Priority to KR1020007009657A priority Critical patent/KR20010074437A/ko
Priority to BR9908445-7A priority patent/BR9908445A/pt
Priority to EP99909743A priority patent/EP1059989A4/fr
Priority to CA002321762A priority patent/CA2321762A1/fr
Priority to AU28882/99A priority patent/AU2888299A/en
Priority to JP2000534310A priority patent/JP2003501112A/ja
Priority to IL13808299A priority patent/IL138082A0/xx
Publication of WO1999044718A1 publication Critical patent/WO1999044718A1/fr
Publication of WO1999044718A8 publication Critical patent/WO1999044718A8/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D36/00—Filter circuits or combinations of filters with other separating devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0218—Multiple bag systems for separating or storing blood components with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0231—Multiple bag systems for separating or storing blood components with gas separating means, e.g. air outlet through microporous membrane or gas bag
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters

Definitions

  • This invention relates generally to liquid filtration techniques. More
  • this invention relates to an in-line gravity driven liquid filtration method usable to filter and collect biological liquids such as blood or blood products.
  • blood filtration devices allow liquid filtrate to remain within the
  • This remaining liquid referred to as a
  • filtration devices allow an undesirably high amount of air that is purged therefrom to
  • the filtration method of the present invention is useable when
  • blood products involves filtering the blood or blood product, collecting the blood or
  • a receiving bag e.g., a conventional transfer or storage bag
  • the blood in the sealed segments of the first length of tubing may then be used for cross-matching, and/or the blood sealed in the segments of the second length of tubing may be used for
  • the air within the receiving bag may be expressed into an air bag which is
  • the blood or blood product may be filtered for removal of cells and
  • the blood or blood product within the segments of the second length of tubing may be any blood or blood product within the segments of the second length of tubing.
  • the filtered cells may be
  • the blood or blood product may be filtered
  • first and second lengths of tubing may be sealed using a heat sealing device.
  • the blood or blood product may be filtered for removal of cells and
  • the blood or blood product within the segments of the second length of tubing may be any blood or blood product within the segments of the second length of tubing.
  • the filtered cells may be
  • the blood or blood product may be filtered
  • first and second lengths of tubing may be sealed using a heat sealing device.
  • Figure 1 depicts a filtration device in an operational assembly with a blood
  • Figure 2 depicts an isometric view of a receiving blood bag, air bag, air bag
  • upstream, top or up refers to a location of the flow of liquid prior to filtration through filter elements within the filtration device of
  • the present invention is intended to be used for in-line gravity filtration of
  • the filtration device used should automatically drain the upstream side when filtration is complete. Preferably, draining occurs without the manipulation of
  • One type of filtration device, useable in the present invention incorporates an
  • a filtration device 223 is depicted in operational
  • bag 294 air bag 295, inlet tube clamp 266, outlet tube clamp 267, and air tube clamp
  • inlet tube clamp 266 For performing filtration, inlet tube clamp 266,
  • tube clamp 267 is opened and air tube clamp 268, preferably located close to the air
  • socket 287 above the center of inlet section 201 may now be attached to a feed blood
  • feed blood bag 293 may be hung from hook 297 on blood bag pole
  • Receiving blood bag 294 and air bag 295 could be placed on a surface such as a
  • feed blood bag 293 is empty it will be collapsed and therefore, close the inlet end of
  • tube clamp 267 located between the filtration device
  • tube clamp 267 can be sealed, typically by heat using a conventional heat
  • safety device which closes portions of tubing by melting the same, by clamping the tubing closed or by any other means to temporarily or permanently seal or close the
  • the blood may now be mixed to ensure consistency, and preferably the blood is mixed after the air is removed, though mixing could occur before removing the air if desired.
  • mixed blood from receiving blood bag 294 can be expressed into air bag tubing 298 to
  • Tube clamp 268 can now be closed and air bag tubing 298 sealed near
  • Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the air bag 295, using any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295.
  • Both outlet tubing 218 and air bag tubing 298 may have segment marks
  • Figure 2 depicts the segment marks 292 on air bag tubing 298.
  • the blood that is sealed in the segments in outlet tubing 218 may be tested for its compatibility with a patient
  • segments of air bag tubing 298 may be tested for the concentration of filtered matter
  • the filtered blood sealed in tubing 298 may be tested for the presence and
  • agents can be tested for the presence and concentration of such agents after filtration.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Cette invention a trait à une technique permettant de filtrer et de recueillir du sang ou des produits sanguins, laquelle technique consiste à filtrer le sang ou le produit sanguin à l'aide d'un dispositif de filtration (223), à recueillir le sang ou le produit sanguin dans une poche (294), à laisser le sang ou le produit sanguin dans une première longueur d'un tuyau aval (218), à mélanger le sang ou le produit sanguin dans la poche (294), à constituer, dans cette première longueur, un ou plusieurs compartiments hermétiquement fermés dans lesquels demeure le sang ou le produit sanguin, celui-ci ou ceux-ci devant être utilisé(s) pour des épreuves de la compatibilité directe, à transférer le sang ou le produit sanguin de la poche (294) dans une seconde longueur de tuyau (298) reliée à cette poche (294) et à constituer, dans cette seconde longueur, un ou plusieurs compartiments hermétiquement fermés dans lesquels demeure le sang ou le produit sanguin, celui-ci ou ceux-ci devant être utilisé(s) pour des épreuves de contrôle de qualité.
PCT/US1999/004544 1998-03-02 1999-03-02 Dispositif permettant de filtrer et de recueillir du sang ou des produits sanguins et technique afferente WO1999044718A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020007009657A KR20010074437A (ko) 1998-03-02 1999-03-02 혈액 또는 혈액 생성물의 여과 및 수집 시스템 및 방법
BR9908445-7A BR9908445A (pt) 1998-03-02 1999-03-02 Sistema e método de filtração e coleta de sangue ou de produtos de sangue
EP99909743A EP1059989A4 (fr) 1998-03-02 1999-03-02 Dispositif permettant de filtrer et de recueillir du sang ou des produits sanguins et technique afferente
CA002321762A CA2321762A1 (fr) 1998-03-02 1999-03-02 Dispositif permettant de filtrer et de recueillir du sang ou des produits sanguins et technique afferente
AU28882/99A AU2888299A (en) 1998-03-02 1999-03-02 System and method of filtering and collecting blood or blood products
JP2000534310A JP2003501112A (ja) 1998-03-02 1999-03-02 血液又は血液産物を濾過しそして採集するシステム及び方法
IL13808299A IL138082A0 (en) 1998-03-02 1999-03-02 System and method for filtering and collecting blood or blood products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7655898P 1998-03-02 1998-03-02
US60/076,558 1998-03-02

Publications (2)

Publication Number Publication Date
WO1999044718A1 true WO1999044718A1 (fr) 1999-09-10
WO1999044718A8 WO1999044718A8 (fr) 2000-02-10

Family

ID=22132781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004544 WO1999044718A1 (fr) 1998-03-02 1999-03-02 Dispositif permettant de filtrer et de recueillir du sang ou des produits sanguins et technique afferente

Country Status (9)

Country Link
EP (1) EP1059989A4 (fr)
JP (1) JP2003501112A (fr)
KR (1) KR20010074437A (fr)
CN (1) CN1227764A (fr)
AU (1) AU2888299A (fr)
BR (1) BR9908445A (fr)
CA (1) CA2321762A1 (fr)
IL (1) IL138082A0 (fr)
WO (1) WO1999044718A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1222935A1 (fr) * 2000-12-04 2002-07-17 Terumo Kabushiki Kaisha Procédé et dispositiv pour obtenir une préparation de sang déporvoue de leucocytes et entrainant moins d'effets secondaires
DE102004035352A1 (de) * 2004-07-21 2006-02-16 Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH Geschlossenes steriles System und Verfahren zum Filtrieren von biologischen oder medizinischen Flüssigkeiten, insbesondere von Vollblut
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10335802B2 (en) 2015-03-18 2019-07-02 Terumo Kabushiki Kaisha Centrifuge and segment holder
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006016421A1 (ja) * 2004-08-12 2008-05-01 株式会社ジェイ・エム・エス 濾過装置及び濾過方法
CN106577636B (zh) * 2016-12-29 2018-01-30 银丰生物工程集团有限公司 一种符合无菌操作要求的新型细胞冻存袋及使用方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180504A (en) * 1991-05-22 1993-01-19 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
US5512187A (en) * 1991-05-08 1996-04-30 Baxter International Inc. Methods for processing red cell products for long term storage free of microorganisms
US5527472A (en) * 1993-06-14 1996-06-18 Baxter International Inc. Closed systems and methods for removing undesired matter from blood cells
US5601730A (en) * 1992-09-02 1997-02-11 Pall Corporation Process and apparatus for removal of unwanted fluids from processed blood products

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68902698C5 (de) * 1988-06-23 2005-07-14 Asahi Medical Co. Ltd. Verfahren zur Trennung von Blut in Blutkomponenten und Einheit zur Trennung von Blutkomponenten.
AU674692B2 (en) * 1992-07-13 1997-01-09 Haemonetics Puerto Rico, Llc Automatic processing of biological fluids such as whole bloodpacked red cells, platelet concentrate & plasma
US6010633A (en) * 1997-03-06 2000-01-04 Hemasure Inc. Method of preventing air from becoming entrapped within a filtration device
DE19712298C2 (de) * 1997-03-24 1999-05-20 Fresenius Ag Vorrichtung und Verfahren zum Trennen von Blut in Blutkomponenten

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512187A (en) * 1991-05-08 1996-04-30 Baxter International Inc. Methods for processing red cell products for long term storage free of microorganisms
US5180504A (en) * 1991-05-22 1993-01-19 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
US5601730A (en) * 1992-09-02 1997-02-11 Pall Corporation Process and apparatus for removal of unwanted fluids from processed blood products
US5527472A (en) * 1993-06-14 1996-06-18 Baxter International Inc. Closed systems and methods for removing undesired matter from blood cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1059989A4 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1222935A1 (fr) * 2000-12-04 2002-07-17 Terumo Kabushiki Kaisha Procédé et dispositiv pour obtenir une préparation de sang déporvoue de leucocytes et entrainant moins d'effets secondaires
US6796954B2 (en) 2000-12-04 2004-09-28 Terumo Kabushiki Kaisha Method for preparing leucocyte-free blood preparation and blood administration set
DE102004035352A1 (de) * 2004-07-21 2006-02-16 Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH Geschlossenes steriles System und Verfahren zum Filtrieren von biologischen oder medizinischen Flüssigkeiten, insbesondere von Vollblut
DE102004035352B4 (de) * 2004-07-21 2007-05-10 Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH Geschlossenes steriles System zum Filtrieren von biologischen oder medizinischen Flüssigkeiten, insbesondere von Vollblut
US7910008B2 (en) 2004-07-21 2011-03-22 Fresenius Hemocare Austria Gmbh Sealed sterile system and method for filtering biological or medical fluids, in particular whole blood
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10183475B2 (en) 2014-03-24 2019-01-22 Fenwal, Inc. Flexible biological fluid filters
US10343093B2 (en) 2014-03-24 2019-07-09 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US10335802B2 (en) 2015-03-18 2019-07-02 Terumo Kabushiki Kaisha Centrifuge and segment holder

Also Published As

Publication number Publication date
EP1059989A4 (fr) 2001-08-22
EP1059989A1 (fr) 2000-12-20
WO1999044718A8 (fr) 2000-02-10
CN1227764A (zh) 1999-09-08
AU2888299A (en) 1999-09-20
BR9908445A (pt) 2000-11-14
CA2321762A1 (fr) 1999-09-10
KR20010074437A (ko) 2001-08-04
IL138082A0 (en) 2001-10-31
JP2003501112A (ja) 2003-01-14

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