WO1999042087A3 - Controlled release potassium chloride pellet based pharmaceutical compositions having a high active ingredient content - Google Patents

Controlled release potassium chloride pellet based pharmaceutical compositions having a high active ingredient content Download PDF

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Publication number
WO1999042087A3
WO1999042087A3 PCT/HU1999/000013 HU9900013W WO9942087A3 WO 1999042087 A3 WO1999042087 A3 WO 1999042087A3 HU 9900013 W HU9900013 W HU 9900013W WO 9942087 A3 WO9942087 A3 WO 9942087A3
Authority
WO
WIPO (PCT)
Prior art keywords
potassium chloride
weight
controlled release
pellets
active ingredient
Prior art date
Application number
PCT/HU1999/000013
Other languages
French (fr)
Other versions
WO1999042087A2 (en
Inventor
Tibor Nagy
Karoly Pataki
Gabor Guenther
Pal Fekete
Gabor Farago
Blanka Lady
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Tibor Nagy
Karoly Pataki
Gabor Guenther
Pal Fekete
Gabor Farago
Blanka Lady
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Tibor Nagy, Karoly Pataki, Gabor Guenther, Pal Fekete, Gabor Farago, Blanka Lady filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to SK1188-2000A priority Critical patent/SK287281B6/en
Priority to PL343268A priority patent/PL193028B1/en
Priority to AU25404/99A priority patent/AU2540499A/en
Publication of WO1999042087A2 publication Critical patent/WO1999042087A2/en
Publication of WO1999042087A3 publication Critical patent/WO1999042087A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

The invention relates to controlled release multi-dosage pharmaceutical composition in solid oral form, preferably in the form of tablets or hard gelatine capsules and having a potassium chloride content of 500-1000 mg per dosage unit characterized by a content of at least 70 % by weight of potassium chloride, in the form of coated or partially uncoated pellets. The tablets or hard gelatine capsules according to the present invention are comprising pellets which contain at least 70 % by weight of potassium chloride, 10-25 % by weight of microcrystalline cellulose, 0.1-0.5 % by weight of an anti-adhesion agent and 0.1-5.0 % by weight of a hydrophobizing agent; a coating layer applied onto said pellets comprising 3-10 % by weight of an ethyl acrylate/methyl methacrylate copolymer and/or an ammonium methacrylate copolymer, a hydrophobizing agent, talc and optionally a dye; and optionally potassium chloride particles and further auxiliary agents applied onto said layer.
PCT/HU1999/000013 1998-02-20 1999-02-19 Controlled release potassium chloride pellet based pharmaceutical compositions having a high active ingredient content WO1999042087A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SK1188-2000A SK287281B6 (en) 1998-02-20 1999-02-19 Controlled release multi-dosage pharmaceutical composition in solid peroral form and method for the preparation thereof
PL343268A PL193028B1 (en) 1998-02-20 1999-02-19 Controlled release potassium chloride pellet based pharmaceutical compositions having a high active ingredient content
AU25404/99A AU2540499A (en) 1998-02-20 1999-02-19 Controlled release potassium chloride pellet based pharmaceutical compositions having a high active ingredient content

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP9800369 1998-02-20
HU9800369A HU221435B (en) 1998-02-20 1998-02-20 Pellet-based pharmaceutical composition of controlled release with high content of potassium-chloride, and process for it's production

Publications (2)

Publication Number Publication Date
WO1999042087A2 WO1999042087A2 (en) 1999-08-26
WO1999042087A3 true WO1999042087A3 (en) 1999-11-25

Family

ID=89996172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU1999/000013 WO1999042087A2 (en) 1998-02-20 1999-02-19 Controlled release potassium chloride pellet based pharmaceutical compositions having a high active ingredient content

Country Status (6)

Country Link
AU (1) AU2540499A (en)
CZ (1) CZ299182B6 (en)
HU (1) HU221435B (en)
PL (1) PL193028B1 (en)
SK (1) SK287281B6 (en)
WO (1) WO1999042087A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19928312A1 (en) * 1999-06-16 2000-12-21 Schering Ag Drug preparation with delayed drug delivery
DE10347242A1 (en) * 2003-10-10 2005-05-04 Wella Ag Dye-containing pellets for dyeing keratin fibers
EP2023903B1 (en) * 2006-05-19 2014-04-23 EGIS Gyógyszergyár Nyilvánosan Müködõ Részvénytársaság Process for the preparation and surface coating of pellets
DE102008063800A1 (en) 2008-12-19 2010-06-24 Henkel Ag & Co. Kgaa Coated colorants
CN102961363B (en) * 2012-12-14 2014-09-17 河南中帅医药科技股份有限公司 Potassium chloride slow release capsule
EP3213747B1 (en) 2016-03-04 2019-02-13 Laboratorio Reig Jofre S.A. Tablets with a high-content of active ingredients useful for treating hair loss or stimulating its growth
EP4308286A1 (en) 2021-03-16 2024-01-24 Symrise AG Active substance capsules

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2087235A (en) * 1980-11-12 1982-05-26 Ciba Geigy Ag A granular delayed-release form of pharmaceutical active substances
WO1984002843A1 (en) * 1983-01-26 1984-08-02 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
GB2157170A (en) * 1984-03-23 1985-10-23 Ciba Geigy Ag Quick-disintegrating pressed shapes
US5397574A (en) * 1993-10-04 1995-03-14 Andrx Pharmaceuticals, Inc. Controlled release potassium dosage form

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2087235A (en) * 1980-11-12 1982-05-26 Ciba Geigy Ag A granular delayed-release form of pharmaceutical active substances
WO1984002843A1 (en) * 1983-01-26 1984-08-02 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
GB2157170A (en) * 1984-03-23 1985-10-23 Ciba Geigy Ag Quick-disintegrating pressed shapes
US5397574A (en) * 1993-10-04 1995-03-14 Andrx Pharmaceuticals, Inc. Controlled release potassium dosage form

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THOMA, K. ET AL: "Preparation and testing of potassium chloride diffusion pellets", PHARM. IND. (1989), 51(6), 685-9, XP002116009 *

Also Published As

Publication number Publication date
SK287281B6 (en) 2010-05-07
WO1999042087A2 (en) 1999-08-26
PL193028B1 (en) 2007-01-31
SK11882000A3 (en) 2001-01-18
CZ299182B6 (en) 2008-05-14
CZ20002858A3 (en) 2001-01-17
HU221435B (en) 2002-10-28
PL343268A1 (en) 2001-08-13
AU2540499A (en) 1999-09-06
HU9800369D0 (en) 1998-04-28
HUP9800369A1 (en) 2000-08-28

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