WO1999036105A3 - USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE - Google Patents
USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE Download PDFInfo
- Publication number
- WO1999036105A3 WO1999036105A3 PCT/US1999/000857 US9900857W WO9936105A3 WO 1999036105 A3 WO1999036105 A3 WO 1999036105A3 US 9900857 W US9900857 W US 9900857W WO 9936105 A3 WO9936105 A3 WO 9936105A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- igm
- cancer
- therapy
- autoimmune disease
- monoclonal igm
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000539876A JP2002509122A (en) | 1998-01-16 | 1999-01-15 | Use of radiolabeled monoclonal IgM in the treatment for cancer and autoimmune diseases |
AU35445/99A AU3544599A (en) | 1998-01-16 | 1999-01-15 | Use of radiolabeled monoclonal igm in therapy for cancer and autoimmune disease |
EP99917293A EP1047457A2 (en) | 1998-01-16 | 1999-01-15 | USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE |
CA002318231A CA2318231A1 (en) | 1998-01-16 | 1999-01-15 | Use of radiolabeled monoclonal igm in therapy for cancer and autoimmune disease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US862098A | 1998-01-16 | 1998-01-16 | |
US09/008,620 | 1998-01-16 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1999036105A2 WO1999036105A2 (en) | 1999-07-22 |
WO1999036105A9 WO1999036105A9 (en) | 1999-10-21 |
WO1999036105A3 true WO1999036105A3 (en) | 2000-02-10 |
Family
ID=21732655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/000857 WO1999036105A2 (en) | 1998-01-16 | 1999-01-15 | USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1047457A2 (en) |
JP (1) | JP2002509122A (en) |
AU (1) | AU3544599A (en) |
CA (1) | CA2318231A1 (en) |
WO (1) | WO1999036105A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002096948A2 (en) | 2001-01-29 | 2002-12-05 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
IL157142A0 (en) * | 2001-01-29 | 2004-02-08 | Idec Pharma Corp | Modified antibodies and methods of use |
AU2004256354B2 (en) | 2003-07-15 | 2011-07-07 | Chugai Seiyaku Kabushiki Kaisha | IgM production by transformed cells and methods for quantifying said IgM production |
WO2005035574A1 (en) | 2003-10-09 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | IgM HIGH CONCENTRATION STABILIZED SOLUTION |
US20060127311A1 (en) * | 2004-11-17 | 2006-06-15 | Duke University | Radiation dosimetry and blocking antibodies and methods and uses therefor in the treatment of cancer |
CN101873854B (en) * | 2007-10-09 | 2014-09-10 | 内华达高等教育***董事会,代表内华达大学雷诺校区 | Laminins, derivatives, and compositions including same and method for their therapeutic use |
KR102289054B1 (en) * | 2019-03-29 | 2021-08-19 | 한국수력원자력 주식회사 | Prevention of rheumatoid arthritis by low-dose ionizing radiation |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015625A1 (en) * | 1989-06-19 | 1990-12-27 | Akzo N.V. | RADIOIMMUNOTHERAPY USING α-PARTICLES EMISSION |
WO1993017707A1 (en) * | 1992-03-04 | 1993-09-16 | Akzo N.V. | In vivo binding pair pretargeting |
US5583219A (en) * | 1989-05-26 | 1996-12-10 | Akzo Nobel N.V. | Macrocyclic chelating agent |
WO1997044461A2 (en) * | 1996-05-22 | 1997-11-27 | Novopharm Biotech, Inc. | Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers |
-
1999
- 1999-01-15 AU AU35445/99A patent/AU3544599A/en not_active Abandoned
- 1999-01-15 EP EP99917293A patent/EP1047457A2/en not_active Withdrawn
- 1999-01-15 WO PCT/US1999/000857 patent/WO1999036105A2/en not_active Application Discontinuation
- 1999-01-15 CA CA002318231A patent/CA2318231A1/en not_active Abandoned
- 1999-01-15 JP JP2000539876A patent/JP2002509122A/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583219A (en) * | 1989-05-26 | 1996-12-10 | Akzo Nobel N.V. | Macrocyclic chelating agent |
WO1990015625A1 (en) * | 1989-06-19 | 1990-12-27 | Akzo N.V. | RADIOIMMUNOTHERAPY USING α-PARTICLES EMISSION |
WO1993017707A1 (en) * | 1992-03-04 | 1993-09-16 | Akzo N.V. | In vivo binding pair pretargeting |
WO1997044461A2 (en) * | 1996-05-22 | 1997-11-27 | Novopharm Biotech, Inc. | Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers |
Non-Patent Citations (11)
Title |
---|
"Ph. D Thesis", 1997, THE UNIVERSITY OF TEXAS H.S.C. AT HOUSTON GRAD. SCH. OF BIOMED. SCI, HOUSTON, US * |
BENACH J L ET AL: "A MURINE IGM MONOCLONAL ANTIBODY BINDS AN ANTIGENIC DETERMINANT IN OUTER SURFACE PROTEIN A, AN IMMUNODOMINANT BASIC PROTEIN OF THE LYME DISEASE SPIROCHETE", JOURNAL OF IMMUNOLOGY, vol. 140, no. 1, 1 January 1988 (1988-01-01), pages 265 - 272, XP002001274 * |
BORCHARDT P.E. ET AL: "Intralesional radiolabeled human monoclonal IgM in human tumor xenografts", RADIOTHERAPY AND ONCOLOGY, 1997, VOL. 44, NO. 3, PAGE(S) 283-293, XP002112294 * |
BORCHARDT PE ET AL: "Indium-111- and yttrium-90- labeled human monoclonal immunoglobulin M targeting of human ovarian cancer in mice.", J NUCL MED, MARCH 1998, VOL. 39, NO. 3, PAGE(S) 476-484, XP002112298 * |
DATABASE DISSERTATION ABSTRACTS University Microflims International; BORCHARDT, PAUL ERIC: "RADIOLABELED HUMAN MONOCLONAL IGM FOR INTRACOMPARTMENTAL CANCER THERAPY (RADIOIMMUNOTHERAPY, INDIUM, YTTRIUM, LYMPHOMAS)", XP002112299 * |
DISSERTATION ABSTRACTS INTERNATIONAL, vol. 58, no. 08 part B, 1997, pages 4177 * |
QUADRI S M: "Intraperitoneal In-111 and Y - 90 labeled human IgM ( AC6C3 -2B12) in nude mice with peritoneal carcinomatosis of a human cancer.", JOURNAL OF NUCLEAR MEDICINE, 1995, VOL. 36, NO. 5, PAGE(S) 160P, XP002112295 * |
QUADRI, SYED M. ET AL: "Intraperitoneal indium-111- and yttrium-90-labeled human IgM (AC6C3-2B12) in nude mice bearing peritoneal carcinomatosis", J. NUCL. MED., 1996, VOL. 37, NO. 9, PAGE(S) 1545-1551, XP002112297 * |
QUADRI, SYED M. ET AL: "Preclinical analysis of intraperitoneal administration of 111In-labeled human tumor reactive monoclonal IgM AC6C3-2B12", CANCER RES., 1995, VOL. 55, NO. 23, SUPPL., PAGE(S) 5736S-5742S, XP002112296 * |
RIVA P ET AL: "LOCOREGIONAL IMMUNOTHERAPY OF HUMAN OVARIAN CANCER: PRELIMINARY RESULTS", INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART B: NUCLEAR MEDICINE AND BIOLOGY, vol. 16, no. 6, 1 January 1989 (1989-01-01), pages 659 - 666, XP000054551 * |
WATANABE N ET AL: "Preparation of Yttrium-90-Labeled Human Macroaggregated Albumin for Regional Radiotherapy", NUCLEAR MEDICINE AND BIOLOGY, vol. 24, no. 5, 1 July 1997 (1997-07-01), pages 465-469, XP004085841 * |
Also Published As
Publication number | Publication date |
---|---|
JP2002509122A (en) | 2002-03-26 |
AU3544599A (en) | 1999-08-02 |
CA2318231A1 (en) | 1999-07-22 |
WO1999036105A2 (en) | 1999-07-22 |
EP1047457A2 (en) | 2000-11-02 |
WO1999036105A9 (en) | 1999-10-21 |
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