WO1999032075A1 - Compositions for inhibiting gingivitis - Google Patents
Compositions for inhibiting gingivitis Download PDFInfo
- Publication number
- WO1999032075A1 WO1999032075A1 PCT/US1998/025496 US9825496W WO9932075A1 WO 1999032075 A1 WO1999032075 A1 WO 1999032075A1 US 9825496 W US9825496 W US 9825496W WO 9932075 A1 WO9932075 A1 WO 9932075A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dentifrice
- menthol
- composition
- eucalyptol
- thymol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
Definitions
- the present invention relates to compositions and a method for
- the invention is directed to a dentifrice
- composition with particular amounts of specific essential oils and a method for
- Volatile or essential oils are widely used in oral care products.
- Essential oils are aromatic compounds that are derived from plant sources or
- Thymol is a well-known substance that is associated with oral malodor, plaque and gingivitis.
- oils include menthol, methyl salicylate, eucalyptol, anethol and eugenol. Essential oils have been included in formulations of toothpaste. U.S.
- Patent No. 1,526,940 to Staegemann teaches a toothpaste with the germicide
- Euthymol toothpaste has a pH
- an antiplaque oral composition including a toothpaste, with triclosan.
- antiplaque activity of the triclosan is increased by essential oils such as eucalyptol,
- an antiseptic, anticaries dentifrice having a pH of about 3.0 to about 5.5.
- dentifrice contains thymol from about 0.01% w/w to about 1.0 % w/w, menthol
- formula contains 20 grains each of thymol, menthol, eucalyptol and oil of
- dental hygiene composition in an acidic pH range of from 3.0 to 5.0, pH buffers,
- composition is methyl salicylate or thyme oil and other flavors such that the composition is
- compositions with antiseptic essential oils there is a need for dentifrice
- compositions providing antigingivitis efficacy. Additionally, there is a need for a
- dentifrice composition containing antigingivitis ingredients that remain stable for
- the present invention is directed to a method of inhibiting gingivitis
- methyl salicylate about 0.7 % w/w to about 1.0% w/w eucalyptol and about 0.3%
- a dentifrice composition used in conjunction with a toothbrush cleans
- Dentifrice compositions of this invention contain
- the composition also has anticaries activity.
- Dentifrice compositions of this invention also contain, but are not limited to, one
- dentifrice additives acidifiers, abrasives, surfactants,
- binders and thickeners binders and thickeners, humectants, sweeteners, desensitizing agents, flavors,
- the dentifrice composition of the invention is acidified
- acidifiers including, but not limited to,
- Essential oils are volatile aromatic oils that are synthetic or are derived
- compositions of this invention antigingivitis activity is provided by essential oils.
- inventions include, but are not limited to, thymol, menthol, methyl salicylate
- Thymol is a white crystalline
- Thymol is soluble in organic solvents but
- Menthol is isolated principally from the oil of Mentha arvensis. In its
- menthol is available as L-menthol crystals obtained from a
- Eucalyptol is derived from the eucalyptus tree. Having a cam-
- Combinations of menthol and eucalyptol are widely used. Particularly preferred uses of the menthol-eucalyptol combination include, according to the
- dentifrices such as toothpastes or dental gels.
- Methyl salicylate is the main ingredient in many essential oils
- the four essential oils used in the present invention are also used in the present invention.
- Listerine® well .known mouthwash Listerine®. The amount of the oils in Listerine®
- mouthwash is 0.064% thymol, 0.092% eucalyptol, 0.060% methyl salicylate and
- Listerine® mouthwash is known to help reduce the incidence of
- the recommended amount of mouthwash used at one time is the recommended amount of mouthwash used at one time.
- thymol about 0.4644% to about 0.5676% methyl salicylate, about 0.306% to
- Fluoride-releasing compounds may be used in the dentifrice
- compositions of the present invention may be fully or slightly
- compositions containing fluoride-releasing compounds help prevent dental caries.
- Typical fluoride-releasing compounds are inorganic fluoride salts such as
- compositions are preferred.
- compositions of this invention must be nontoxic. The specific amount depends on
- the fluoride-releasing compound will be present in an amount by weight
- composition so as to provide 800 - 1500 ppm F " .
- invention is from about 4.0 to about 5.0.
- a pH greater than about 5.0 has been
- pH of the dentifrice compositions from about 4.0 to about 5.0 also provides for a
- the pH of the claimed dentifrice is adjusted to below 5.0 using suitable
- Acidifiers in the present invention include
- o sodium phosphate from about 0.01% w/w to about 1% w/w, preferably from about
- the pH of the products may be buffered with salts of the acids in
- citric acid-sodium citrate examples include citric acid-sodium citrate, phosphoric acid-sodium phosphate, sodium
- composition and most preferably from about 0.1% w/w to about 0.5% w/w of the
- compositions of the present invention may also contain
- conventional dentifrice additives including, but not limited to, humectants,
- binders thickeners, surfactants, preservatives, sweeteners, flavors, colors,
- glycerin glycerin, and a buffer. These additives are present in amounts that do not interfere with the antiseptic, antigingivitis and anticaries properties of the composition of
- Surfactants or surface active agents are organic compounds that reduce
- the surfactant in the present invention may be anionic,
- present invention may contain surfactants in amounts up to about 5.0% w/w; pre ⁇
- the most preferred surfactants are anionic. These anionic
- surfactants include, but are not limited to, sodium lauryl sulfate, sodium lauroyl
- compositions according to the invention are sodium lauryl sulfate.
- present invention are substantially free from one or more highly pure alkali metal
- .Amphoteric surfactants have the capacity to behave as either an acid or
- a base and include quaternized imidazole derivatives.
- surfactants include long chain (alkyl) amino-alkylene aklylated amine derivatives
- MIRANOL® manufactured by Rhone-Poulanc, Cranberry, New
- the sweetener may be selected from a wide range of well .known
- soluble saccharin salts e.g., sodium or calcium
- Dipeptide sweeteners include
- Naturally occurring water-soluble sweeteners include,
- sugar alcohols including sorbitol as 70% sorbitol solution,
- mannitol xylitol
- maltitol hydrogenated starch hydrolysates and mixtures thereof.
- water-soluble sweeteners include, but are not limited to, chlorinated derivatives of sucrose, .known, for example, under the product designation of Sucralose; and
- Protein-based sweeteners such as thaumaoccous danielli (Thaumatin I and II).
- Sorbitol solution supplies sweetness and body to the composition
- Sorbitol solution also enhances flavor, prevents
- an effective amount of sweetener is utilized to provide the
- composition The exact range of amounts for each type of sweetener in a
- dentifrice is readily determined by those skill in the art.
- the flavors that may be used in the invention include natural and
- Suitable flavors include, but are not
- mints such as peppermint
- citrus flavors such as orange and lemon
- camphor, p-propenyl anisole is a flavor constituent of anise and fennel oils that
- the flavors are preferably utilized in amounts that may
- the dentifrice composition range from about 0.01% w/w to about 6% w/w of the dentifrice composition.
- flavors used in the compositions according to the present invention comprise
- flavoring oils that are not substantially free of terpenes.
- coloring agents may be incorporated in amounts up to
- the coloring agents may also
- coloring agents are known as FD & C dyes and lakes.
- coloring materials are preferably water-soluble.
- Illustrative nonlimiting examples are exemplary nonlimiting examples
- titanium dioxide may be incorporated in amounts up to about 2.0% w/w,
- composition preferably less than about 1.0% w/w of the composition and most preferably less
- Suitable humectants in this invention include sorbitol, as 70% sorbitol
- Humectants may be present in amounts from about 1.0% to about 75.0% by
- Suitable abrasive substances for use in this invention must be
- composition according to this invention may include among others, ZEODENT®
- polishing agents manufactured by W.R. Grace Co. These polishing agents may be used in amounts
- composition up to about 75.0% w/w of the composition, preferably in amounts from about
- the dentifrice composition includes an oral vehicle that can be a paste,
- composition may also include binders or gelling agents to provide a desired
- Gelling agents such as hydroxyethyl cellulose, carboxymethyl
- cellulose methyl cellulose, xanthan gum, gelling silicas and the like may be used
- the preferred gelling system is a mixture of carboxy
- Gelling agents may be used in
- the dentifrice composition of this invention may also contain a
- desensitizing agent such as strontium chloride, potassium nitrate or sodium citrate-
- citric acid which may be used in an amount from about 0.5% w/w to about 10%
- Suitable preservatives include benzoic acid, butylated hydroxyanisole
- BHA butylated hydroxytoluene
- BHT butylated hydroxytoluene
- ascorbic acid methyl paraben
- methyl paraben propyl
- Dentifrice compositions were formulated with the ingredients listed in
- the plaque index used was the Turesky modification of the Quigley-Hein
- index scores the amount of the toothsurface covered with plaque using a 0-5 point
- the bleeding index used was the Gingival Bleeding Index as described in
- Example 1 The subjects using Example 1 had a 39.6% reduction in Plaque Index, a
- Example 2 The procedures and indices used in Example 2 were also used in
- Example 3 In addition to the indices measured in the three week study, the
- interproximal Plaque Index The subjects were measured at three and six months.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR9813729-8A BR9813729A (en) | 1997-12-22 | 1998-12-02 | Compositions for gingivitis inhibition |
CA002300205A CA2300205A1 (en) | 1997-12-22 | 1998-12-02 | Compositions for inhibiting gingivitis |
JP2000525071A JP2001526202A (en) | 1997-12-22 | 1998-12-02 | Composition for controlling gingivitis |
AU17076/99A AU1707699A (en) | 1997-12-22 | 1998-12-02 | Compositions for inhibiting gingivitis |
EP98961857A EP1041959A1 (en) | 1997-12-22 | 1998-12-02 | Compositions for inhibiting gingivitis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6839197P | 1997-12-22 | 1997-12-22 | |
US60/068,391 | 1997-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999032075A1 true WO1999032075A1 (en) | 1999-07-01 |
Family
ID=22082272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/025496 WO1999032075A1 (en) | 1997-12-22 | 1998-12-02 | Compositions for inhibiting gingivitis |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1041959A1 (en) |
JP (1) | JP2001526202A (en) |
AU (1) | AU1707699A (en) |
BR (1) | BR9813729A (en) |
CA (1) | CA2300205A1 (en) |
WO (1) | WO1999032075A1 (en) |
ZA (1) | ZA9811727B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002525306A (en) * | 1998-09-25 | 2002-08-13 | ワーナー−ランバート・カンパニー | Rapidly dissolving oral consumable film |
CN114306141A (en) * | 2021-12-31 | 2022-04-12 | 赣南医学院 | Active composition for mouthwash, mouthwash and preparation method of active composition |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4482270B2 (en) * | 2002-10-31 | 2010-06-16 | 花王株式会社 | Oral composition |
JP2017119639A (en) * | 2015-12-28 | 2017-07-06 | 花王株式会社 | TRPV4 activator |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5094843A (en) * | 1990-09-10 | 1992-03-10 | Beecham Inc. | Antimicrobial toothpaste |
WO1996003109A1 (en) * | 1994-07-25 | 1996-02-08 | Warner-Lambert Company | Antiseptic dentifrice |
WO1997015277A1 (en) * | 1995-10-23 | 1997-05-01 | Warner-Lambert Company | Enhanced stannous oral composition |
EP0803243A2 (en) * | 1996-04-24 | 1997-10-29 | Pfizer Inc. | Cyclodextrins and phenolic compounds in dental products |
WO1997040812A1 (en) * | 1996-04-26 | 1997-11-06 | Warner-Lambert Company | Enhanced zinc containing oral composition |
-
1998
- 1998-12-02 BR BR9813729-8A patent/BR9813729A/en not_active IP Right Cessation
- 1998-12-02 JP JP2000525071A patent/JP2001526202A/en active Pending
- 1998-12-02 EP EP98961857A patent/EP1041959A1/en not_active Withdrawn
- 1998-12-02 AU AU17076/99A patent/AU1707699A/en not_active Abandoned
- 1998-12-02 CA CA002300205A patent/CA2300205A1/en not_active Abandoned
- 1998-12-02 WO PCT/US1998/025496 patent/WO1999032075A1/en not_active Application Discontinuation
- 1998-12-21 ZA ZA9811727A patent/ZA9811727B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5094843A (en) * | 1990-09-10 | 1992-03-10 | Beecham Inc. | Antimicrobial toothpaste |
WO1996003109A1 (en) * | 1994-07-25 | 1996-02-08 | Warner-Lambert Company | Antiseptic dentifrice |
WO1997015277A1 (en) * | 1995-10-23 | 1997-05-01 | Warner-Lambert Company | Enhanced stannous oral composition |
EP0803243A2 (en) * | 1996-04-24 | 1997-10-29 | Pfizer Inc. | Cyclodextrins and phenolic compounds in dental products |
WO1997040812A1 (en) * | 1996-04-26 | 1997-11-06 | Warner-Lambert Company | Enhanced zinc containing oral composition |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002525306A (en) * | 1998-09-25 | 2002-08-13 | ワーナー−ランバート・カンパニー | Rapidly dissolving oral consumable film |
US7407669B2 (en) | 1998-09-25 | 2008-08-05 | Mcneil-Ppc, Inc. | Fast dissolving orally consumable films |
US7491406B2 (en) | 1998-09-25 | 2009-02-17 | Mcneil-Ppc, Inc. | Fast dissolving orally consumable films |
CN114306141A (en) * | 2021-12-31 | 2022-04-12 | 赣南医学院 | Active composition for mouthwash, mouthwash and preparation method of active composition |
Also Published As
Publication number | Publication date |
---|---|
JP2001526202A (en) | 2001-12-18 |
EP1041959A1 (en) | 2000-10-11 |
AU1707699A (en) | 1999-07-12 |
CA2300205A1 (en) | 1999-07-01 |
BR9813729A (en) | 2000-10-10 |
ZA9811727B (en) | 1999-06-24 |
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