WO1999026975A3 - Method for obtaining biologically active dimers of recombinant human growth factors from the cysteine knot family, use of dimers thus obtained - Google Patents
Method for obtaining biologically active dimers of recombinant human growth factors from the cysteine knot family, use of dimers thus obtained Download PDFInfo
- Publication number
- WO1999026975A3 WO1999026975A3 PCT/EP1998/007051 EP9807051W WO9926975A3 WO 1999026975 A3 WO1999026975 A3 WO 1999026975A3 EP 9807051 W EP9807051 W EP 9807051W WO 9926975 A3 WO9926975 A3 WO 9926975A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dimers
- growth factors
- recombinant human
- biologically active
- human growth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98965656A EP1028976A2 (en) | 1997-11-05 | 1998-11-05 | Method for obtaining biologically active dimers of recombinant human growth factors from the cysteine knot family, use of dimers thus obtained |
JP2000522131A JP2001524304A (en) | 1997-11-05 | 1998-11-05 | Method for producing biologically active dimer of cysteine-knot family recombinant human growth factor and use of the generated dimer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1997148734 DE19748734A1 (en) | 1997-11-05 | 1997-11-05 | Preparing active growth factor dimers from inclusion bodies in high yield |
DE19748734.3 | 1997-11-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999026975A2 WO1999026975A2 (en) | 1999-06-03 |
WO1999026975A3 true WO1999026975A3 (en) | 1999-08-12 |
Family
ID=7847606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/007051 WO1999026975A2 (en) | 1997-11-05 | 1998-11-05 | Method for obtaining biologically active dimers of recombinant human growth factors from the cysteine knot family, use of dimers thus obtained |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1028976A2 (en) |
JP (1) | JP2001524304A (en) |
DE (1) | DE19748734A1 (en) |
WO (1) | WO1999026975A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69628652T3 (en) | 1995-09-08 | 2012-05-03 | Genentech, Inc. | VEGF-RELATED PROTEIN |
ES2284816T3 (en) * | 2002-02-05 | 2007-11-16 | Geymonat S.P.A. | PRODUCTION PROCESS OF A RECOMBINANT PLACENTARY GROWTH FACTOR. |
ITRM20020277A1 (en) * | 2002-05-17 | 2003-11-17 | Geymonat Spa | TYPE 1 PLACENTAR GROWTH FACTOR MUTEINE, PREPARATION METHOD AND THEIR APPLICATIONS. |
EP1449848A1 (en) * | 2003-02-20 | 2004-08-25 | GBF German Research Centre for Biotechnology | Method for the production of cystine-knot proteins |
EP1692505B1 (en) * | 2003-11-03 | 2012-09-05 | Danisco US Inc. | Cd4+ epitopes of bone morphogenetic proteins |
EP2975120A1 (en) * | 2014-07-17 | 2016-01-20 | Institut Pasteur | Monomeric and functional adenylate cyclase CyaA toxin |
CA2995751A1 (en) * | 2015-08-25 | 2017-03-02 | Histide Ag | Compounds for inducing tissue formation and uses thereof |
US11578110B2 (en) | 2015-08-25 | 2023-02-14 | Histide Ag | Compounds for inducing tissue formation and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0504751A1 (en) * | 1991-03-22 | 1992-09-23 | CEINGE SOCIETA CONSORTILE a.r.l. | Method for the preparation of interleukin 6 |
EP0553494A1 (en) * | 1991-12-31 | 1993-08-04 | Lucky Ltd. | Recombinant gene coding for human alpha interferon and expression vector thereof, ETC. |
-
1997
- 1997-11-05 DE DE1997148734 patent/DE19748734A1/en not_active Withdrawn
-
1998
- 1998-11-05 WO PCT/EP1998/007051 patent/WO1999026975A2/en not_active Application Discontinuation
- 1998-11-05 JP JP2000522131A patent/JP2001524304A/en active Pending
- 1998-11-05 EP EP98965656A patent/EP1028976A2/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0504751A1 (en) * | 1991-03-22 | 1992-09-23 | CEINGE SOCIETA CONSORTILE a.r.l. | Method for the preparation of interleukin 6 |
EP0553494A1 (en) * | 1991-12-31 | 1993-08-04 | Lucky Ltd. | Recombinant gene coding for human alpha interferon and expression vector thereof, ETC. |
Also Published As
Publication number | Publication date |
---|---|
JP2001524304A (en) | 2001-12-04 |
EP1028976A2 (en) | 2000-08-23 |
DE19748734A1 (en) | 1999-05-06 |
WO1999026975A2 (en) | 1999-06-03 |
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