WO1999019481A3 - Mammalian genes involved in viral infection and tumor suppression - Google Patents

Mammalian genes involved in viral infection and tumor suppression Download PDF

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Publication number
WO1999019481A3
WO1999019481A3 PCT/US1998/021276 US9821276W WO9919481A3 WO 1999019481 A3 WO1999019481 A3 WO 1999019481A3 US 9821276 W US9821276 W US 9821276W WO 9919481 A3 WO9919481 A3 WO 9919481A3
Authority
WO
WIPO (PCT)
Prior art keywords
viral infection
genes involved
tumor suppression
mammalian genes
methods
Prior art date
Application number
PCT/US1998/021276
Other languages
French (fr)
Other versions
WO1999019481A2 (en
Inventor
Donald H Rubin
Edward L Organ
Raymond N Dubois
Original Assignee
Univ Vanderbilt
Donald H Rubin
Edward L Organ
Raymond N Dubois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt, Donald H Rubin, Edward L Organ, Raymond N Dubois filed Critical Univ Vanderbilt
Priority to US09/509,712 priority Critical patent/US6777177B1/en
Priority to AU96041/98A priority patent/AU9604198A/en
Priority to JP2000516033A priority patent/JP2001520012A/en
Priority to EP98949800A priority patent/EP1021536A2/en
Priority to CA2305312A priority patent/CA2305312C/en
Publication of WO1999019481A2 publication Critical patent/WO1999019481A2/en
Publication of WO1999019481A3 publication Critical patent/WO1999019481A3/en
Priority to US10/877,807 priority patent/US20050112553A1/en
Priority to US11/033,764 priority patent/US20050244817A1/en
Priority to US12/210,869 priority patent/US20090092594A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/60—Vectors containing traps for, e.g. exons, promoters

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides methods of identifying cellular genes necessary for viral growth and cellular genes that function as tumor suppressors. Thus, the present invention provides nucleic acids related to and methods of reducing or preventing viral infection or cancer. The invention also provides methods of producing substantially virus-free cell cultures and methods for screening for additional such genes.
PCT/US1998/021276 1996-04-15 1998-10-08 Mammalian genes involved in viral infection and tumor suppression WO1999019481A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US09/509,712 US6777177B1 (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression
AU96041/98A AU9604198A (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression
JP2000516033A JP2001520012A (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression
EP98949800A EP1021536A2 (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression
CA2305312A CA2305312C (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression
US10/877,807 US20050112553A1 (en) 1997-10-10 2004-06-25 Mammalian genes involved in viral infection and tumor suppression
US11/033,764 US20050244817A1 (en) 1996-04-15 2005-01-12 Mammalian genes involved in viral infection and tumor suppression
US12/210,869 US20090092594A1 (en) 1996-04-15 2008-09-15 Mammalian genes involved in viral infection and tumor suppression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6202197P 1997-10-10 1997-10-10
US60/062,021 1997-10-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/877,807 Continuation US20050112553A1 (en) 1996-04-15 2004-06-25 Mammalian genes involved in viral infection and tumor suppression

Publications (2)

Publication Number Publication Date
WO1999019481A2 WO1999019481A2 (en) 1999-04-22
WO1999019481A3 true WO1999019481A3 (en) 1999-11-04

Family

ID=22039706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/021276 WO1999019481A2 (en) 1996-04-15 1998-10-08 Mammalian genes involved in viral infection and tumor suppression

Country Status (5)

Country Link
EP (1) EP1021536A2 (en)
JP (2) JP2001520012A (en)
AU (1) AU9604198A (en)
CA (2) CA2696653A1 (en)
WO (1) WO1999019481A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016323A2 (en) * 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
JP2002300900A (en) * 2001-04-05 2002-10-15 National Institute Of Advanced Industrial & Technology Method for screening tumor-worsening factor and tumor worsening-inhibiting compound
US20030087273A1 (en) * 2001-06-29 2003-05-08 Holzmayer Tanya A. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
AU2003234445B2 (en) * 2002-05-02 2009-11-26 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression
EP2339009A1 (en) * 2009-12-22 2011-06-29 Sandoz Ag Cold inducible promoter sequences

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009192A1 (en) * 1989-02-14 1990-08-23 Massachusetts Institute Of Technology Inhibiting transformation of cells having elevated purine metabolic enzyme activity
WO1993009230A1 (en) * 1991-11-05 1993-05-13 Board Of Regents, The University Of Texas System Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
US5627058A (en) * 1990-05-14 1997-05-06 Massachusetts Institute Of Technology Retrovirus promoter-trap vectors
WO1997039119A1 (en) * 1996-04-15 1997-10-23 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009192A1 (en) * 1989-02-14 1990-08-23 Massachusetts Institute Of Technology Inhibiting transformation of cells having elevated purine metabolic enzyme activity
US5627058A (en) * 1990-05-14 1997-05-06 Massachusetts Institute Of Technology Retrovirus promoter-trap vectors
WO1993009230A1 (en) * 1991-11-05 1993-05-13 Board Of Regents, The University Of Texas System Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
WO1997039119A1 (en) * 1996-04-15 1997-10-23 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
E. ORGAN ET AL.: "U3 gene-trap retrovirus selection of cellular mutants resistant to lytic reovirus infection", J. INVESTIGATIVE MEDICINE, ISSN: 1081-5589,, vol. 44, no. 3, March 1996 (1996-03-01), pages 320A, XP002090533 *
EVANS M J ET AL: "Gene trapping and functional genomics", TRENDS IN GENETICS, vol. 13, no. 9, September 1997 (1997-09-01), pages 370-374, XP004086832 *
SKARNES W C: "THE IDENTIFICATION OF NEW GENES: GENE TRAPPING IN TRANSGENIC MICE", CURRENT OPINION IN BIOTECHNOLOGY, vol. 4, 1 January 1993 (1993-01-01), pages 684 - 689, XP000569473 *

Also Published As

Publication number Publication date
AU9604198A (en) 1999-05-03
CA2305312A1 (en) 1999-04-22
JP2001520012A (en) 2001-10-30
JP2009100780A (en) 2009-05-14
EP1021536A2 (en) 2000-07-26
CA2696653A1 (en) 1999-04-22
WO1999019481A2 (en) 1999-04-22
CA2305312C (en) 2010-03-23

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