WO1999007738A3 - Human orphan receptor ntr-1 - Google Patents

Human orphan receptor ntr-1 Download PDF

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Publication number
WO1999007738A3
WO1999007738A3 PCT/US1998/016202 US9816202W WO9907738A3 WO 1999007738 A3 WO1999007738 A3 WO 1999007738A3 US 9816202 W US9816202 W US 9816202W WO 9907738 A3 WO9907738 A3 WO 9907738A3
Authority
WO
WIPO (PCT)
Prior art keywords
ntr
orphan receptor
provides
human
present
Prior art date
Application number
PCT/US1998/016202
Other languages
French (fr)
Other versions
WO1999007738A2 (en
Inventor
Piotr J Masiakowski
Jodi Morris
David M Valenzuela
Original Assignee
Regeneron Pharma
Procter & Gamble Compagny
Piotr J Masiakowski
Jodi Morris
David M Valenzuela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Procter & Gamble Compagny, Piotr J Masiakowski, Jodi Morris, David M Valenzuela filed Critical Regeneron Pharma
Priority to JP2000506239A priority Critical patent/JP2001512667A/en
Priority to CA002299619A priority patent/CA2299619A1/en
Priority to AU87676/98A priority patent/AU8767698A/en
Priority to EP98939199A priority patent/EP1019502A2/en
Publication of WO1999007738A2 publication Critical patent/WO1999007738A2/en
Publication of WO1999007738A3 publication Critical patent/WO1999007738A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides for a nucleic acid sequence, designated as HUMAN NTR-1, that encodes a novel orphan receptor expressed in pancreas and fetal heart. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the HUMAN NTR-1 gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between NTR-1 and agents that initiate signal transduction through binding to NTR-1.
PCT/US1998/016202 1997-08-06 1998-08-04 Human orphan receptor ntr-1 WO1999007738A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000506239A JP2001512667A (en) 1997-08-06 1998-08-04 Human orphan receptor NTR-1
CA002299619A CA2299619A1 (en) 1997-08-06 1998-08-04 Human orphan receptor ntr-1
AU87676/98A AU8767698A (en) 1997-08-06 1998-08-04 Novel orphan receptor
EP98939199A EP1019502A2 (en) 1997-08-06 1998-08-04 Human orphan receptor ntr-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5486997P 1997-08-06 1997-08-06
US60/054,869 1997-08-06

Publications (2)

Publication Number Publication Date
WO1999007738A2 WO1999007738A2 (en) 1999-02-18
WO1999007738A3 true WO1999007738A3 (en) 1999-04-15

Family

ID=21994032

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/016202 WO1999007738A2 (en) 1997-08-06 1998-08-04 Human orphan receptor ntr-1

Country Status (5)

Country Link
EP (1) EP1019502A2 (en)
JP (1) JP2001512667A (en)
AU (1) AU8767698A (en)
CA (1) CA2299619A1 (en)
WO (1) WO1999007738A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
KR20000070174A (en) 1997-01-14 2000-11-25 벤슨 로버트 에이치. Tumor necrosis factor receptors 6α and 6β
AU762959B2 (en) 1997-09-18 2003-07-10 Genentech Inc. DcR3 polypeptide, A TNFR homolog
WO1999026977A1 (en) * 1997-11-24 1999-06-03 Biogen, Inc. Novel receptors opg-2
WO1999031128A2 (en) * 1997-12-16 1999-06-24 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins
DE19809978A1 (en) * 1998-03-09 1999-09-16 Basf Ag New soluble member of tumor necrosis factor receptor family, useful for identification specific modulators and for treating disease e.g. tumors
KR20010042364A (en) * 1998-03-30 2001-05-25 피터 지. 스트링거 Therapeutic Applications of Mature FLINT(mFLINT) Polypeptides or OPG3, A Member of the TNF Receptor Superfamily
EP1140138A2 (en) * 1998-12-22 2001-10-10 Eli Lilly And Company Therapeutic applications of flint polypeptides
AU767378B2 (en) 1999-02-10 2003-11-06 Genset Polymorphic markers of the LSR gene
CN1345329A (en) * 1999-03-04 2002-04-17 人体基因组科学有限公司 Tumor mecrosis factor receptors 6 alpha and beta
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US6965012B1 (en) * 1999-03-30 2005-11-15 Eli Lilly And Company Flint polypeptide analogs
US6627199B1 (en) 1999-07-09 2003-09-30 Amgen Inc Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
AU6517800A (en) 1999-08-04 2001-03-05 Amgen, Inc. Ntr3, a member of the tnf-receptor supergene family
US6521422B1 (en) 1999-08-04 2003-02-18 Amgen Inc. Fhm, a novel member of the TNF ligand supergene family
US7338787B2 (en) 2000-01-14 2008-03-04 Serono Genetics Institute S.A. Nucleic acids encoding OBG3 globular head and uses thereof
ES2267593T3 (en) 2000-02-16 2007-03-16 Genentech, Inc. ANTI-APRIL ANTIBODIES AND HYBRIDOMA CELLS.
DK2857516T3 (en) 2000-04-11 2017-08-07 Genentech Inc Multivalent antibodies and uses thereof
CA2415473A1 (en) 2000-07-27 2002-02-07 Genentech, Inc. Apo-2l receptor agonist and cpt-11 synergism
WO2003066661A2 (en) 2001-07-03 2003-08-14 Genentech, Inc. Human dr4 antibodies and uses thereof
CA2629306A1 (en) 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851A (en) * 1992-04-02 1995-09-05 Board Of Regents, The University Of Texas System DNA encoding a chimeric polypeptide comprising the extracellular domain of TNF receptor fused to IgG, vectors, and host cells
DE19654610A1 (en) * 1995-12-22 1997-06-26 Amgen Inc Osteoproteger
WO1998030694A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
EP0861850A1 (en) * 1997-02-04 1998-09-02 Smithkline Beecham Corporation Tumor necrosis related receptor, TR4

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851A (en) * 1992-04-02 1995-09-05 Board Of Regents, The University Of Texas System DNA encoding a chimeric polypeptide comprising the extracellular domain of TNF receptor fused to IgG, vectors, and host cells
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
DE19654610A1 (en) * 1995-12-22 1997-06-26 Amgen Inc Osteoproteger
WO1998030694A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
EP0861850A1 (en) * 1997-02-04 1998-09-02 Smithkline Beecham Corporation Tumor necrosis related receptor, TR4

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HILLIER L ET AL: "Human cDNA clone 366305", EMBL SEQUENCE DATABASE, 16 August 1996 (1996-08-16), HEIDELBERG DE, XP002091562 *
HILLIER L ET AL: "Human cDNA clone 592256", EMBL SEQUENCE DATABASE, 18 January 1997 (1997-01-18), HEIDELBERG DE, XP002091560 *

Also Published As

Publication number Publication date
JP2001512667A (en) 2001-08-28
CA2299619A1 (en) 1999-02-18
WO1999007738A2 (en) 1999-02-18
EP1019502A2 (en) 2000-07-19
AU8767698A (en) 1999-03-01

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