WO1999000346A8 - Synthesis of dihydrohonokiol compositions - Google Patents

Synthesis of dihydrohonokiol compositions

Info

Publication number
WO1999000346A8
WO1999000346A8 PCT/US1998/013265 US9813265W WO9900346A8 WO 1999000346 A8 WO1999000346 A8 WO 1999000346A8 US 9813265 W US9813265 W US 9813265W WO 9900346 A8 WO9900346 A8 WO 9900346A8
Authority
WO
WIPO (PCT)
Prior art keywords
dihydrohonokiol
synthesis
compositions
disclosed
homologs
Prior art date
Application number
PCT/US1998/013265
Other languages
French (fr)
Other versions
WO1999000346A1 (en
Inventor
William B Stavinoha
Neera Satsangi
Rajiv K Satsangi
Original Assignee
Univ Texas
William B Stavinoha
Neera Satsangi
Rajiv K Satsangi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, William B Stavinoha, Neera Satsangi, Rajiv K Satsangi filed Critical Univ Texas
Priority to JP50574599A priority Critical patent/JP2002507211A/en
Priority to CA002297723A priority patent/CA2297723A1/en
Priority to EP98931609A priority patent/EP0991614A1/en
Priority to AU81689/98A priority patent/AU8168998A/en
Publication of WO1999000346A1 publication Critical patent/WO1999000346A1/en
Publication of WO1999000346A8 publication Critical patent/WO1999000346A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

The synthesis and use of the anxiolytic compound dihydrohonokiol, its derivatives, analogs and homologs are disclosed. A method for reducing anxiety in a mammal is also disclosed.
PCT/US1998/013265 1997-06-26 1998-06-26 Synthesis of dihydrohonokiol compositions WO1999000346A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP50574599A JP2002507211A (en) 1997-06-26 1998-06-26 Synthesis of dihydrohonokiol composition
CA002297723A CA2297723A1 (en) 1997-06-26 1998-06-26 Synthesis of dihydrohonokiol compositions
EP98931609A EP0991614A1 (en) 1997-06-26 1998-06-26 Synthesis of dihydrohonokiol compositions
AU81689/98A AU8168998A (en) 1997-06-26 1998-06-26 Synthesis of dihydrohonokiol compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5084597P 1997-06-26 1997-06-26
US60/050,845 1997-06-26

Publications (2)

Publication Number Publication Date
WO1999000346A1 WO1999000346A1 (en) 1999-01-07
WO1999000346A8 true WO1999000346A8 (en) 2000-02-17

Family

ID=21967834

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/013265 WO1999000346A1 (en) 1997-06-26 1998-06-26 Synthesis of dihydrohonokiol compositions

Country Status (5)

Country Link
EP (1) EP0991614A1 (en)
JP (1) JP2002507211A (en)
AU (1) AU8168998A (en)
CA (1) CA2297723A1 (en)
WO (1) WO1999000346A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1140756A2 (en) * 1998-12-31 2001-10-10 The Board Of Regents, The University Of Texas System Synthesis of dihydrohonokiol compositions
US20050070537A1 (en) * 2002-10-10 2005-03-31 Chris Rundfeldt Use of dihydroimidazolones for the treatment of dogs
CN101223120A (en) * 2005-02-23 2008-07-16 杰克·L·阿比瑟 Honokiol derivatives for the treatment of proliferative disorders
CN101279901B (en) * 2007-12-25 2011-08-17 四川大学 Honokiol series derivates, preparation and use thereof
EP2423181A1 (en) 2010-07-28 2012-02-29 Prous Institute For Biomedical Research S.A. Multitarget substituted biphenyl diol derivatives
US9486419B2 (en) 2013-04-17 2016-11-08 Ariel-University Research And Development Company CB2 receptor ligands for the treatment of psychiatric disorders
US9820988B2 (en) 2014-03-24 2017-11-21 Boehringer Ingelheim Vetmedica Gmbh Treatment of epileptic disorders in feline animals
US10836782B2 (en) 2015-06-11 2020-11-17 The Medical College Of Wisconsin, Inc. Mito-honokiol compounds and methods of synthesis and use thereof
US11897910B2 (en) 2015-06-11 2024-02-13 The Medical College Of Wisconsin, Inc. Mito-honokiol compounds and methods of synthesis and use thereof
CN108430463B (en) * 2015-10-23 2021-01-29 高露洁-棕榄公司 Improved synthesis of honokiol
CA3149491A1 (en) * 2019-08-06 2021-02-11 Justin KIRKLAND Formulations including dihydrohonokiol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5995229A (en) * 1982-11-24 1984-06-01 Tsumura Juntendo Inc Novel hydroxybiphenyl compound
EP0382213B1 (en) * 1989-02-08 1995-05-10 Otsuka Pharmaceutical Co., Ltd. Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent
US5449682A (en) * 1990-02-13 1995-09-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted benzyl element

Also Published As

Publication number Publication date
JP2002507211A (en) 2002-03-05
CA2297723A1 (en) 1999-01-07
AU8168998A (en) 1999-01-19
WO1999000346A1 (en) 1999-01-07
EP0991614A1 (en) 2000-04-12

Similar Documents

Publication Publication Date Title
AU2959995A (en) Stereochemical wortmannin derivatives
PL330635A1 (en) Inhibitor of cytokin production, triazepin compound and intermediate compounds used for obtaining the last mentioned one
AU9785098A (en) Synthesis of sapo-44
AU4677199A (en) Multibinding inhibitors of topoisomerase
EP0977563A4 (en) Synthesis of epothilones, intermediates thereto, analogues and uses thereof
AU6718494A (en) 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
WO1999002514A3 (en) Epothilone derivatives
HUP0004250A3 (en) Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates
AU3631197A (en) N-benzylpiperidine and tetrahydropyridine derivatives
PL329153A1 (en) Derivatives of pyrrolopyrolone as inhibitors of neutropil elastase
WO1999000346A8 (en) Synthesis of dihydrohonokiol compositions
AU5235299A (en) Spectral topography of mammalian matter
AU2001269063A1 (en) Shortened synthesis of 3,3-diarylpropylamine derivatives
AU5652698A (en) (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors
AU3255097A (en) Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors
WO2000040532A3 (en) Synthesis of dihydrohonokiol compositions
AU6250298A (en) Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
WO1998017230A3 (en) New 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivatives
AU5737498A (en) Method for the preparation of alpha-bromo-lactam derivatives
AU4415797A (en) New pde iv inhibitors: "bis-compounds"
AUPP342298A0 (en) Hydraulic fastening of components
HUP0003857A3 (en) Method for preparing alkyloxy furanone-amine derivatives, compounds obtained by said method and use of said compounds
AU5115598A (en) Novel pentaerythritol derivatives, preparation and use thereof and intermediates for the synthesis thereof
AU5210298A (en) Methods for the preparation of benzophenone derivatives
AU4997199A (en) Process for the synthesis of benzopyran derivatives

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1998931609

Country of ref document: EP

ENP Entry into the national phase in:

Ref document number: 2297723

Country of ref document: CA

Ref country code: CA

Ref document number: 2297723

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: C1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
WWP Wipo information: published in national office

Ref document number: 1998931609

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1998931609

Country of ref document: EP