WO1998051667A1 - Derives d'indole et derives de mono- et diazaindole - Google Patents

Derives d'indole et derives de mono- et diazaindole Download PDF

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Publication number
WO1998051667A1
WO1998051667A1 PCT/JP1998/002139 JP9802139W WO9851667A1 WO 1998051667 A1 WO1998051667 A1 WO 1998051667A1 JP 9802139 W JP9802139 W JP 9802139W WO 9851667 A1 WO9851667 A1 WO 9851667A1
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
mono
diazaindole
indole
compounds
Prior art date
Application number
PCT/JP1998/002139
Other languages
English (en)
Japanese (ja)
Inventor
Hiroharu Matsuoka
Noriaki Maruyama
Hirotaka Kashiwagi
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to AU72379/98A priority Critical patent/AU7237998A/en
Publication of WO1998051667A1 publication Critical patent/WO1998051667A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule générale (I). Dans ladite formule, A1 est =N- etc.; A2 est =N- ou =CH-; R1 est hydrogène etc; R3 est alkyle etc.; R4 est aryle éventuellement substitué etc. On décrit lesdits composés, leurs hydrates et sels pharmaceutiquement acceptables. Ces composés ont une action inhibitrice sur COX-2 et sont utiles comme médicaments, par exemple du type antiphlogistique.
PCT/JP1998/002139 1997-05-16 1998-05-15 Derives d'indole et derives de mono- et diazaindole WO1998051667A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU72379/98A AU7237998A (en) 1997-05-16 1998-05-15 Indole derivatives and mono- and diazaindole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12705997 1997-05-16
JP9/127059 1997-05-16

Publications (1)

Publication Number Publication Date
WO1998051667A1 true WO1998051667A1 (fr) 1998-11-19

Family

ID=14950582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/002139 WO1998051667A1 (fr) 1997-05-16 1998-05-15 Derives d'indole et derives de mono- et diazaindole

Country Status (2)

Country Link
AU (1) AU7237998A (fr)
WO (1) WO1998051667A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012187A2 (fr) * 1999-08-18 2001-02-22 Astrazeneca Ab Composes chimiques
WO2003029212A1 (fr) * 2001-09-27 2003-04-10 F. Hoffmann-La Roche Ag Derives d'indole utiles comme inhibiteurs de cox ii
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7683091B2 (en) 2005-08-17 2010-03-23 Wyeth Substituted indoles and methods of their use
WO2011013624A1 (fr) * 2009-07-27 2011-02-03 キッセイ薬品工業株式会社 Dérivé d'indole et ses sels pharmacologiquement acceptables
CN102498097A (zh) * 2009-07-27 2012-06-13 橘生药品工业株式会社 吲哚衍生物或其可药用盐
JP2012167085A (ja) * 2011-01-25 2012-09-06 Kissei Pharmaceutical Co Ltd インドール誘導体、またはその薬理学的に許容される塩の医薬用途
WO2022195579A1 (fr) 2021-03-15 2022-09-22 Saul Yedgar Dipalmitoyl-phosphatidyl-éthanol-amine conjuguée à l'acide hyaluronique en combinaison avec des médicaments anti-inflammatoires non stéroïdiens (ains) pour traiter ou soulager des maladies inflammatoires

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018799A1 (fr) * 1994-01-10 1995-07-13 Merck Frosst Canada Inc. Heterocycles phenyliques utilises comme inhibiteurs de cox-2
JPH08504408A (ja) * 1992-12-11 1996-05-14 メルク フロスト カナダ インコーポレーテツド シクロオキシゲナーゼ−２阻害剤としての５−メタンスルホンアミド−１−インダノン
JPH08157631A (ja) * 1994-10-05 1996-06-18 Sekisui Chem Co Ltd ポリオレフィン系架橋発泡体及びその製造方法
JPH08325249A (ja) * 1994-12-20 1996-12-10 Japan Tobacco Inc オキサゾール誘導体
JPH0952882A (ja) * 1994-12-20 1997-02-25 Japan Tobacco Inc オキサゾール系複素環式芳香族化合物
JPH0977664A (ja) * 1995-09-13 1997-03-25 Yakult Honsha Co Ltd シクロオキシゲナーゼ−２特異的阻害剤及び抗炎症剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08504408A (ja) * 1992-12-11 1996-05-14 メルク フロスト カナダ インコーポレーテツド シクロオキシゲナーゼ−２阻害剤としての５−メタンスルホンアミド−１−インダノン
WO1995018799A1 (fr) * 1994-01-10 1995-07-13 Merck Frosst Canada Inc. Heterocycles phenyliques utilises comme inhibiteurs de cox-2
JPH08157631A (ja) * 1994-10-05 1996-06-18 Sekisui Chem Co Ltd ポリオレフィン系架橋発泡体及びその製造方法
JPH08325249A (ja) * 1994-12-20 1996-12-10 Japan Tobacco Inc オキサゾール誘導体
JPH0952882A (ja) * 1994-12-20 1997-02-25 Japan Tobacco Inc オキサゾール系複素環式芳香族化合物
JPH0977664A (ja) * 1995-09-13 1997-03-25 Yakult Honsha Co Ltd シクロオキシゲナーゼ−２特異的阻害剤及び抗炎症剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GLAMKOWSKI E. J., REITANO P. A.: "SYNTHESIS AND EVALUATION FOR DIURETIC ACTIVITY OF 1-SUBSTITUTED 6- CHLORO-5-SULFAMYLINDOLINES.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 22., no. 01., 1 January 1979 (1979-01-01), US, pages 106 - 109., XP002912309, ISSN: 0022-2623, DOI: 10.1021/jm00187a023 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012187A2 (fr) * 1999-08-18 2001-02-22 Astrazeneca Ab Composes chimiques
WO2001012187A3 (fr) * 1999-08-18 2001-06-07 Astrazeneca Ab Composes chimiques
WO2003029212A1 (fr) * 2001-09-27 2003-04-10 F. Hoffmann-La Roche Ag Derives d'indole utiles comme inhibiteurs de cox ii
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7683091B2 (en) 2005-08-17 2010-03-23 Wyeth Substituted indoles and methods of their use
CN102498097A (zh) * 2009-07-27 2012-06-13 橘生药品工业株式会社 吲哚衍生物或其可药用盐
WO2011013624A1 (fr) * 2009-07-27 2011-02-03 キッセイ薬品工業株式会社 Dérivé d'indole et ses sels pharmacologiquement acceptables
CN102498096A (zh) * 2009-07-27 2012-06-13 橘生药品工业株式会社 吲哚衍生物或其可药用盐
EP2474530A1 (fr) * 2009-07-27 2012-07-11 Kissei Pharmaceutical Co., Ltd. Dérivé d'indole et sel pharmacologiquement acceptable de celui-ci
EP2474530A4 (fr) * 2009-07-27 2013-01-02 Kissei Pharmaceutical Dérivé d'indole et sel pharmacologiquement acceptable de celui-ci
JPWO2011013624A1 (ja) * 2009-07-27 2013-01-07 キッセイ薬品工業株式会社 インドール誘導体、またはその薬理学的に許容される塩
US8680120B2 (en) 2009-07-27 2014-03-25 Kissei Pharmaceutical Co., Ltd. Indole derivative or pharmaceutically acceptable salt thereof
JP2012167085A (ja) * 2011-01-25 2012-09-06 Kissei Pharmaceutical Co Ltd インドール誘導体、またはその薬理学的に許容される塩の医薬用途
WO2022195579A1 (fr) 2021-03-15 2022-09-22 Saul Yedgar Dipalmitoyl-phosphatidyl-éthanol-amine conjuguée à l'acide hyaluronique en combinaison avec des médicaments anti-inflammatoires non stéroïdiens (ains) pour traiter ou soulager des maladies inflammatoires

Also Published As

Publication number Publication date
AU7237998A (en) 1998-12-08

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