WO1998032858A3 - Mammalian chemokines; receptors; reagents; uses - Google Patents

Mammalian chemokines; receptors; reagents; uses Download PDF

Info

Publication number
WO1998032858A3
WO1998032858A3 PCT/US1998/000902 US9800902W WO9832858A3 WO 1998032858 A3 WO1998032858 A3 WO 1998032858A3 US 9800902 W US9800902 W US 9800902W WO 9832858 A3 WO9832858 A3 WO 9832858A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagents
receptors
chemokines
mammalian chemokines
mammalian
Prior art date
Application number
PCT/US1998/000902
Other languages
French (fr)
Other versions
WO1998032858A2 (en
Inventor
Jeanine D Mattson
Hortensia Soto-Trejo
Joseph A Hedrick
Daniel M Gorman
Albert Zlotnik
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU61326/98A priority Critical patent/AU6132698A/en
Publication of WO1998032858A2 publication Critical patent/WO1998032858A2/en
Publication of WO1998032858A3 publication Critical patent/WO1998032858A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding said chemokines or receptors. Methods of using said reagents and diagnostic kits are also provided.
PCT/US1998/000902 1997-01-23 1998-01-22 Mammalian chemokines; receptors; reagents; uses WO1998032858A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU61326/98A AU6132698A (en) 1997-01-23 1998-01-22 Mammalian chemokines; receptors; reagents; uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3671597P 1997-01-23 1997-01-23
US60/036,715 1997-01-23

Publications (2)

Publication Number Publication Date
WO1998032858A2 WO1998032858A2 (en) 1998-07-30
WO1998032858A3 true WO1998032858A3 (en) 1998-11-12

Family

ID=21890201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000902 WO1998032858A2 (en) 1997-01-23 1998-01-22 Mammalian chemokines; receptors; reagents; uses

Country Status (2)

Country Link
AU (1) AU6132698A (en)
WO (1) WO1998032858A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US6140064A (en) 1996-09-10 2000-10-31 Theodor-Kocher Institute Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3
US6576445B1 (en) 1996-09-12 2003-06-10 Human Genome Sciences, Inc. Chemokine α-4
WO1999013082A1 (en) * 1997-09-12 1999-03-18 Incyte Pharmaceuticals, Inc. Cxc chemokine
AU1824499A (en) * 1997-12-30 1999-07-19 Chiron Corporation Human cxc chemokine ((tim-1))
CA2320144A1 (en) * 1998-02-10 1999-08-12 Millennium Pharmaceuticals, Inc. Neokine protein and nucleic acid molecules and uses therefor
US6573095B1 (en) 1998-04-29 2003-06-03 Genesis Research & Development Corporation Limited Polynucleotides isolated from skin cells
EP1676861A3 (en) * 1998-10-13 2006-07-19 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human G protein-coupled receptors
US20030229216A1 (en) 1998-10-13 2003-12-11 Ruoping Chen Constitutively activated human G protein coupled receptors
US6329159B1 (en) 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US6919176B2 (en) 2001-05-07 2005-07-19 Amgen Inc. Polypeptides and nucleic acids associated with cancer
WO2003065045A2 (en) * 2002-02-01 2003-08-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with the gpr65 receptor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016979A1 (en) * 1994-11-29 1996-06-06 Incyte Pharmaceuticals, Inc. Expressed chemokines, their production and uses
WO1996022371A2 (en) * 1995-01-19 1996-07-25 Leukosite, Inc. C-C CHEMOKINE RECEPTOR 3: CKP-3 OR Eos-L2
WO1996039520A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Human chemokine beta-12
WO1997000960A1 (en) * 1995-06-23 1997-01-09 Leukosite, Inc. Novel human chemotactic cytokine
WO1997035010A1 (en) * 1996-03-19 1997-09-25 Human Genome Sciences, Inc. Chemokine alpha 2

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016979A1 (en) * 1994-11-29 1996-06-06 Incyte Pharmaceuticals, Inc. Expressed chemokines, their production and uses
WO1996022371A2 (en) * 1995-01-19 1996-07-25 Leukosite, Inc. C-C CHEMOKINE RECEPTOR 3: CKP-3 OR Eos-L2
WO1996039520A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Human chemokine beta-12
WO1997000960A1 (en) * 1995-06-23 1997-01-09 Leukosite, Inc. Novel human chemotactic cytokine
WO1997035010A1 (en) * 1996-03-19 1997-09-25 Human Genome Sciences, Inc. Chemokine alpha 2

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COMBADIERE C ET AL: "CLONING AND FUNCTIONAL EXPRESSION OF CC CKR5, A HUMAN MONOCYTE CC CHEMOKINE RECEPTOR SELECTIVE FOR MIP-1ALPHA, MIP-1BETA, AND RANTES", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 60, no. 1, July 1996 (1996-07-01), pages 147 - 152, XP002055732 *
J.A. HEDRICK ET AL: "Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10", BLOOD, vol. 91, no. 11, 1 June 1998 (1998-06-01), pages 4242 - 4247, XP002076800 *
M.R. SANDHYA ET AL: "Characterization of beta-R1, a gene that is selectively induced by Interferon beta (IFN-beta) compared with IFN-alpha", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 271, no. 37, 13 September 1996 (1996-09-13), MD US, pages 22878 - 22884, XP002076799 *
SCHALL T J ET AL: "CHEMOKINES, LEUKOCYTE TRAFFICKING, AND INFLAMMATION", CURRENT OPINION IN IMMUNOLOGY, vol. 6, no. 6, December 1994 (1994-12-01), pages 865 - 873, XP002048194 *

Also Published As

Publication number Publication date
WO1998032858A2 (en) 1998-07-30
AU6132698A (en) 1998-08-18

Similar Documents

Publication Publication Date Title
WO1997021812A3 (en) Mammalian chemokine ccf8 and chemokine receptor cckr3
EP2100959A3 (en) Mammalian cytokine: interleukin-B30 and related reagents
CA2263129A1 (en) Mammalian cell surface antigens; related reagents
WO1998001557A3 (en) Mammalian chemokine reagents
WO1998027114A3 (en) Mammalian cell surface antigens; related reagents
WO1995018826A3 (en) Purified primate ctla-8 antigens and related reagents
WO2000042188A3 (en) Interleukin-17 related mammalian cytokines. polynucleotides encoding them. uses
EP1114864A3 (en) Mammalian cell surface antigens, related reagents
EP1980573A3 (en) Isolated dendritic cell membrane protein genes
WO1998011226A3 (en) Mammalian chemokines, related reagents
WO1998024906A3 (en) Isolated mammalian monocyte cell genes; related reagents
WO1998032858A3 (en) Mammalian chemokines; receptors; reagents; uses
EP1897949A3 (en) Human interleukin-B50. Therapeutic uses
EP1942114A3 (en) Mammalian cytokines; related reagents and methods
WO1998023750A3 (en) Mammalian chemokines
AU1825097A (en) Mammalian cx3c chemokine genes
WO1998031810A3 (en) Mammalian chemokines; receptors; reagents; uses
WO1998039421A3 (en) Mammalian proteinases; oxidoreductases; gtp binding proteins; related reagents
WO2003020005A3 (en) Lp mammalian proteins; related reagents
WO1999047673A3 (en) Isolated mammalian membrane protein genes and related reagents
AU1695595A (en) Mammalian thymokine genes
EP0997476A3 (en) Antibodies to a mammalian Langerhans cell antigen and their uses
WO2002068596A3 (en) Mammalian cytokines; related reagents
BR9713632A (en) Il-10 related mammalian cytokine
WO2002074906A3 (en) Lp mammalian proteins; related reagents

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CZ EE GE GW HU ID IL IS JP KG KR KZ LC LK LR LT LV MD MG MK MN MX NO NZ PL RO RU SG SI SK SL TJ TM TR TT UA UZ VN YU

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998532052

Format of ref document f/p: F

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA