WO1998031735A1 - Improved polypropylene suture material - Google Patents

Improved polypropylene suture material Download PDF

Info

Publication number
WO1998031735A1
WO1998031735A1 PCT/US1997/012328 US9712328W WO9831735A1 WO 1998031735 A1 WO1998031735 A1 WO 1998031735A1 US 9712328 W US9712328 W US 9712328W WO 9831735 A1 WO9831735 A1 WO 9831735A1
Authority
WO
WIPO (PCT)
Prior art keywords
suture material
branched chain
improved
polypropylene
surgical
Prior art date
Application number
PCT/US1997/012328
Other languages
French (fr)
Inventor
Russell L. Stainfield
Andrea M. Sadowski
Original Assignee
Aristech Chemical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aristech Chemical Corporation filed Critical Aristech Chemical Corporation
Publication of WO1998031735A1 publication Critical patent/WO1998031735A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/04—Non-resorbable materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/10—Homopolymers or copolymers of propene
    • C08L23/12—Polypropene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L91/00—Compositions of oils, fats or waxes; Compositions of derivatives thereof
    • C08L91/06—Waxes

Definitions

  • This invention is drawn to an improved extrusion grade polypropylene based formulation suitable for use as surgical suture material.
  • the improved suture material possesses enhanced physical properties including: suppleness, softness, fray resistance, knot retention and skin slipperiness.
  • the present invention is drawn to an improved formulation for polypropylene.
  • This improved formulation is useful in the production of surgical sutures and the like.
  • surgical sutures made of polypropylene have suffered from the drawbacks of: (1) lacking suppleness and softness; (2) being prone to fraying when a surgical knot is slid down the suture; and (3) not maintaining skin slipperiness.
  • sutures Menezes et al, in U.S. Patent Nos. 4,520,822 and 4,620,542 disclose surgical monofilament sutures.
  • the sutures are said to possess improved compliance, compared with polypropylene homopolymer sutures.
  • these sutures suffer from the above drawbacks.
  • the sutures of the present invention possess superior suppleness, softness, fray resistance, knot retention and skin slipperiness.
  • Hinsch in U.S. Patent No. 4,577,264 discloses surgical filaments such as sutures and ligatures made of a blend of polypropylene and linear low density polyethylene. These sutures are not subject to the above drawbacks.
  • the present invention overcomes the same drawbacks without the need for a low density polyethylene additive.
  • the present invention attains these superior properties by incorporating a branched chain polyolefin wax, such as a polyethylene wax, into the blend. Additionally, the present invention attains these superior properties with lower concentrations of additive than is taught by the Hinch reference.
  • the object of present invention is to provide an improved formulation for polypropylene useful in the production of surgical sutures and the like. It is a further objective of the present invention to provide for a surgical suture material having improved suppleness, softness, fray resistance, knot retention and having improved skin slipperiness.
  • a further object of the present invention is to provide for an improved additive package to be used in combination with typical extrusion grade polypropylene formulations.
  • Another object of the invention is to provide for a suture material suitable for use within the human body.
  • the improved suture material must be suitable for use in surgical material. That is, the material must be approved by the relevant governmental agency(s) regulating materials suitable for use in medical application.
  • the present invention provides for a polypropylene surgical material comprising extrusion grade polypropylene.
  • the polypropylene is made as is common in the art. For example, as disclosed in the '264 reference.
  • the improvement comprises the addition of a branched chain polyolefin wax, to a typical additive package for polypropylene blend suture material.
  • Typical polypropylene suture material composition additive packages are well known in the art. For example, additive packages as disclosed in any of the cited references.
  • the present invention is an improved material suitable for use as a surgical suture material.
  • the material comprises extrusion grade polypropylene suitable for use as a surgical suture material and the like. These materials are well known in the art.
  • the material comprises a polypropylene homopolymer.
  • F-040-A suture grade polypropylene material manufactured by Aristech Chemical Corporation.
  • the improvement of the present invention comprises the addition of a branched chain polyolefin wax to the polypropylene blend formulation.
  • the olefin wax is a branched chain low molecular weight polyolefin wax such as a branched chain low molecular weight polyethylene wax.
  • a branched chain low molecular weight polyethylene wax such as AC-617, manufactured by Allied Signal.
  • the was is added in an amount of about 0.1 to 2.0 wt%. Preferably, 0.5 to 0.95 wt%.
  • a 2 melt flow homopolymer reactor powder is blended in: 0.2 wt% of a lubricant such as calcium stearate; 0.2 wt% anti-static agent, 0.4 wt% of a thermal stabilizer, 0.2 wt% of a primary anti-oxidant, and 0.75 wt% AC-617 branched chain low molecular weight polyethylene wax. Wherein all additive quantities measured +/- 20%.
  • a lubricant such as calcium stearate
  • anti-static agent 0.2 wt% anti-static agent
  • 0.4 wt% of a thermal stabilizer 0.2 wt% of a primary anti-oxidant
  • 0.75 wt% AC-617 branched chain low molecular weight polyethylene wax 0.75 wt% AC-617 branched chain low molecular weight polyethylene wax.

Abstract

The present invention is an improved composition suitable for use as a surgical suture material. The composition comprises the addition of a branched chain polyolefin wax to typical extrusion grade polypropylene suitable for surgical applications. The improved suture material enhances the suppleness, softness, fray resistance, knot retention and skin slipperiness of the suture material.

Description

IMPROVED POLYPROPYLENE SUTURE MATERIAL
Technical Field
This invention is drawn to an improved extrusion grade polypropylene based formulation suitable for use as surgical suture material. The improved suture material possesses enhanced physical properties including: suppleness, softness, fray resistance, knot retention and skin slipperiness.
Background of the Invention
The present invention is drawn to an improved formulation for polypropylene. This improved formulation is useful in the production of surgical sutures and the like. Until now, surgical sutures made of polypropylene have suffered from the drawbacks of: (1) lacking suppleness and softness; (2) being prone to fraying when a surgical knot is slid down the suture; and (3) not maintaining skin slipperiness.
Menezes et al, in U.S. Patent Nos. 4,520,822 and 4,620,542 disclose surgical monofilament sutures. The sutures are said to possess improved compliance, compared with polypropylene homopolymer sutures. However, these sutures suffer from the above drawbacks. The sutures of the present invention possess superior suppleness, softness, fray resistance, knot retention and skin slipperiness.
Hinsch, in U.S. Patent No. 4,577,264 discloses surgical filaments such as sutures and ligatures made of a blend of polypropylene and linear low density polyethylene. These sutures are not subject to the above drawbacks. However, the present invention overcomes the same drawbacks without the need for a low density polyethylene additive. The present invention attains these superior properties by incorporating a branched chain polyolefin wax, such as a polyethylene wax, into the blend. Additionally, the present invention attains these superior properties with lower concentrations of additive than is taught by the Hinch reference.
Object of the Invention
The object of present invention is to provide an improved formulation for polypropylene useful in the production of surgical sutures and the like. It is a further objective of the present invention to provide for a surgical suture material having improved suppleness, softness, fray resistance, knot retention and having improved skin slipperiness.
A further object of the present invention is to provide for an improved additive package to be used in combination with typical extrusion grade polypropylene formulations.
Another object of the invention is to provide for a suture material suitable for use within the human body. As is required in the art, the improved suture material must be suitable for use in surgical material. That is, the material must be approved by the relevant governmental agency(s) regulating materials suitable for use in medical application.
The present invention provides for a polypropylene surgical material comprising extrusion grade polypropylene. The polypropylene is made as is common in the art. For example, as disclosed in the '264 reference. The improvement comprises the addition of a branched chain polyolefin wax, to a typical additive package for polypropylene blend suture material. Typical polypropylene suture material composition additive packages are well known in the art. For example, additive packages as disclosed in any of the cited references.
Detailed Description of the Invention
The present invention is an improved material suitable for use as a surgical suture material. The material comprises extrusion grade polypropylene suitable for use as a surgical suture material and the like. These materials are well known in the art. Preferably, the material comprises a polypropylene homopolymer. For example, F-040-A suture grade polypropylene material manufactured by Aristech Chemical Corporation.
The improvement of the present invention comprises the addition of a branched chain polyolefin wax to the polypropylene blend formulation. Preferably, the olefin wax is a branched chain low molecular weight polyolefin wax such as a branched chain low molecular weight polyethylene wax. For example, AC-617, manufactured by Allied Signal. The was is added in an amount of about 0.1 to 2.0 wt%. Preferably, 0.5 to 0.95 wt%.
The invention is illustrated by the following Example:
Example 1
To a set quantity of a 2 melt flow homopolymer reactor powder is blended in: 0.2 wt% of a lubricant such as calcium stearate; 0.2 wt% anti-static agent, 0.4 wt% of a thermal stabilizer, 0.2 wt% of a primary anti-oxidant, and 0.75 wt% AC-617 branched chain low molecular weight polyethylene wax. Wherein all additive quantities measured +/- 20%. The above composition is extruded into pellet form. The pellets are later extruded into suture filaments.

Claims

Claims
1. A composition suitable for surgical suture material comprising a blend of:
(a) an extrusion grade polypropylene composition; and
(b) 0.1-0.95 wt % of a branched chain polyolefin wax.
2. A composition according to claim 1 wherein 0.5-0.95 wt% of the branched chain polyolefin wax is added.
3. A composition according to claim 1 wherein the branched chain polyolefin wax is a branched chain low molecular weight polyethylene wax.
4. A composition according to claim 1 wherein the polypropylene is an extrusion grade homopolymer.
5. A suture material comprising a blend of:
(a) an extrusion grade polypropylene composition; and
(b) 0.1-0.95 wt% of a branched chain polyolefin wax.
6. A method of making a surgical suture comprising the steps of:
(a) blending: an extrusion grade polypropylene composition and 0.1-0.95 wt% of a branched chain polyolefin wax to make a blend;
(b) extruding the blend into at least one surgical suture filament.
PCT/US1997/012328 1997-01-21 1997-07-14 Improved polypropylene suture material WO1998031735A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78659497A 1997-01-21 1997-01-21
US08/786,594 1997-01-21

Publications (1)

Publication Number Publication Date
WO1998031735A1 true WO1998031735A1 (en) 1998-07-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012328 WO1998031735A1 (en) 1997-01-21 1997-07-14 Improved polypropylene suture material

Country Status (1)

Country Link
WO (1) WO1998031735A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076521A2 (en) * 2001-03-26 2002-10-03 Tyco Healthcare Group Lp Polyolefin sutures having improved processing and handling characteristics
WO2009152487A3 (en) * 2008-06-13 2010-08-19 Smith & Nephew, Inc. Fixation devices for tissue repair
WO2012162135A1 (en) * 2011-05-20 2012-11-29 The Procter & Gamble Company A disposable article comprising fibers of polymer -wax compositions
WO2012162130A1 (en) * 2011-05-20 2012-11-29 The Procter & Gamble Company Fibers of polymer-wax compositions
US9205006B2 (en) 2013-03-15 2015-12-08 The Procter & Gamble Company Absorbent articles with nonwoven substrates having fibrils
US9504610B2 (en) 2013-03-15 2016-11-29 The Procter & Gamble Company Methods for forming absorbent articles with nonwoven substrates
US11090407B2 (en) 2017-03-09 2021-08-17 The Procter & Gamble Company Thermoplastic polymeric materials with heat activatable compositions
US11110013B2 (en) 2014-09-10 2021-09-07 The Procter & Gamble Company Nonwoven webs with hydrophobic and hydrophilic layers
US11129919B2 (en) 2016-03-09 2021-09-28 The Procter & Gamble Company Absorbent article with activatable material

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3791388A (en) * 1971-09-22 1974-02-12 Ethicon Inc Covered suture
US4701487A (en) * 1983-06-06 1987-10-20 Petrolite Corporation Extrusion processing aid composition and polyolefin containing same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3791388A (en) * 1971-09-22 1974-02-12 Ethicon Inc Covered suture
US4701487A (en) * 1983-06-06 1987-10-20 Petrolite Corporation Extrusion processing aid composition and polyolefin containing same

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076521A2 (en) * 2001-03-26 2002-10-03 Tyco Healthcare Group Lp Polyolefin sutures having improved processing and handling characteristics
WO2002076521A3 (en) * 2001-03-26 2003-02-27 Tyco Healthcare Polyolefin sutures having improved processing and handling characteristics
WO2009152487A3 (en) * 2008-06-13 2010-08-19 Smith & Nephew, Inc. Fixation devices for tissue repair
US9926653B2 (en) 2011-05-20 2018-03-27 The Procter & Gamble Company Fibers of polymer-wax compositions
WO2012162130A1 (en) * 2011-05-20 2012-11-29 The Procter & Gamble Company Fibers of polymer-wax compositions
CN103561780A (en) * 2011-05-20 2014-02-05 宝洁公司 A disposable article comprising fibers of polymer-wax compositions
CN103562291A (en) * 2011-05-20 2014-02-05 宝洁公司 Fibers of polymer-wax compositions
US11339514B2 (en) 2011-05-20 2022-05-24 The Procter & Gamble Company Fibers of polymer-wax compositions
US9328440B2 (en) 2011-05-20 2016-05-03 The Procter & Gamble Company Fibers of polymer-wax compositions
US10151055B2 (en) 2011-05-20 2018-12-11 The Procter & Gamble Company Fibers of polymer-wax compositions
WO2012162135A1 (en) * 2011-05-20 2012-11-29 The Procter & Gamble Company A disposable article comprising fibers of polymer -wax compositions
US10016319B2 (en) 2013-03-15 2018-07-10 The Procter & Gamble Company Absorbent articles with nonwoven substrates having fibrils
US9974700B2 (en) 2013-03-15 2018-05-22 The Procter & Gamble Company Absorbent articles with nonwoven substrates having fibrils
US9504610B2 (en) 2013-03-15 2016-11-29 The Procter & Gamble Company Methods for forming absorbent articles with nonwoven substrates
US10993855B2 (en) 2013-03-15 2021-05-04 The Procter & Gamble Company Absorbent articles with nonwoven substrates having fibrils
US9205006B2 (en) 2013-03-15 2015-12-08 The Procter & Gamble Company Absorbent articles with nonwoven substrates having fibrils
US11110013B2 (en) 2014-09-10 2021-09-07 The Procter & Gamble Company Nonwoven webs with hydrophobic and hydrophilic layers
US11839531B2 (en) 2014-09-10 2023-12-12 The Procter And Gamble Company Nonwoven webs with hydrophobic and hydrophilic layers
US11129919B2 (en) 2016-03-09 2021-09-28 The Procter & Gamble Company Absorbent article with activatable material
US11090407B2 (en) 2017-03-09 2021-08-17 The Procter & Gamble Company Thermoplastic polymeric materials with heat activatable compositions

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