WO1998029069B1 - Procede de modification de la refringence d'un oeil - Google Patents
Procede de modification de la refringence d'un oeilInfo
- Publication number
- WO1998029069B1 WO1998029069B1 PCT/US1997/023794 US9723794W WO9829069B1 WO 1998029069 B1 WO1998029069 B1 WO 1998029069B1 US 9723794 W US9723794 W US 9723794W WO 9829069 B1 WO9829069 B1 WO 9829069B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- refractive power
- eye
- change
- composition according
- composition
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 claims abstract 6
- 150000003431 steroids Chemical class 0.000 claims abstract 4
- 210000002469 Basement Membrane Anatomy 0.000 claims abstract 2
- 230000036040 emmetropia Effects 0.000 claims abstract 2
- 229960001209 CLONIXIN Drugs 0.000 claims 2
- CLOMYZFHNHFSIQ-UHFFFAOYSA-N Clonixin Chemical compound CC1=C(Cl)C=CC=C1NC1=NC=CC=C1C(O)=O CLOMYZFHNHFSIQ-UHFFFAOYSA-N 0.000 claims 2
- 229960004369 Flufenamic Acid Drugs 0.000 claims 2
- LPEPZBJOKDYZAD-UHFFFAOYSA-N Flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 claims 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N Indometacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 2
- 230000003110 anti-inflammatory Effects 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- RUAYXHSDAMWEDR-UHFFFAOYSA-N 2-(4-tert-butylphenyl)acetic acid Chemical compound CC(C)(C)C1=CC=C(CC(O)=O)C=C1 RUAYXHSDAMWEDR-UHFFFAOYSA-N 0.000 claims 1
- SNUBSRMFCPAKSI-UHFFFAOYSA-N 2-(dimethylamino)ethanol;2-(4-phenylphenyl)butanoic acid Chemical compound CN(C)CCO.C1=CC(C(C(O)=O)CC)=CC=C1C1=CC=CC=C1 SNUBSRMFCPAKSI-UHFFFAOYSA-N 0.000 claims 1
- XKSAJZSJKURQRX-UHFFFAOYSA-N 2-acetyloxy-5-(4-fluorophenyl)benzoic acid Chemical compound C1=C(C(O)=O)C(OC(=O)C)=CC=C1C1=CC=C(F)C=C1 XKSAJZSJKURQRX-UHFFFAOYSA-N 0.000 claims 1
- UREBDLICKHMUKA-DVTGEIKXSA-N Betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 1
- 210000004087 Cornea Anatomy 0.000 claims 1
- JYGXADMDTFJGBT-VWUMJDOOSA-N Cortisol Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 1
- 229950007979 FLUFENISAL Drugs 0.000 claims 1
- 229960001419 Fenoprofen Drugs 0.000 claims 1
- RDJGLLICXDHJDY-UHFFFAOYSA-N Fenoprofen Chemical compound OC(=O)C(C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-UHFFFAOYSA-N 0.000 claims 1
- FAOZLTXFLGPHNG-KNAQIMQKSA-N Fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 claims 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N Flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- 229960000905 Indomethacin Drugs 0.000 claims 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N Ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N Ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 claims 1
- YMBXTVYHTMGZDW-UHFFFAOYSA-N Loxoprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1CC1C(=O)CCC1 YMBXTVYHTMGZDW-UHFFFAOYSA-N 0.000 claims 1
- GZENKSODFLBBHQ-ILSZZQPISA-N Medrysone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@H](C(C)=O)CC[C@H]21 GZENKSODFLBBHQ-ILSZZQPISA-N 0.000 claims 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N Mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 claims 1
- 229950008948 Namoxyrate Drugs 0.000 claims 1
- CMWTZPSULFXXJA-VIFPVBQESA-N Naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N Prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N Prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 229960001487 RIMEXOLONE Drugs 0.000 claims 1
- QTTRZHGPGKRAFB-OOKHYKNYSA-N Rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 claims 1
- 229960004492 Suprofen Drugs 0.000 claims 1
- MDKGKXOCJGEUJW-UHFFFAOYSA-N Suprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-UHFFFAOYSA-N 0.000 claims 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N Triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 1
- -1 alkylofenac Chemical compound 0.000 claims 1
- 229960002537 betamethasone Drugs 0.000 claims 1
- 229960001048 fluorometholone Drugs 0.000 claims 1
- 229960002390 flurbiprofen Drugs 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- CYWFCPPBTWOZSF-UHFFFAOYSA-N ibufenac Chemical compound CC(C)CC1=CC=C(CC(O)=O)C=C1 CYWFCPPBTWOZSF-UHFFFAOYSA-N 0.000 claims 1
- 229950009183 ibufenac Drugs 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 229960000991 ketoprofen Drugs 0.000 claims 1
- 229960004752 ketorolac Drugs 0.000 claims 1
- 229960002373 loxoprofen Drugs 0.000 claims 1
- 229960001011 medrysone Drugs 0.000 claims 1
- 229960003464 mefenamic acid Drugs 0.000 claims 1
- 229960002009 naproxen Drugs 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- 229960005294 triamcinolone Drugs 0.000 claims 1
- 206010020675 Hypermetropia Diseases 0.000 abstract 1
- 208000001491 Myopia Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000004305 hyperopia Effects 0.000 abstract 1
- 201000006318 hyperopia Diseases 0.000 abstract 1
- 230000004379 myopia Effects 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Abstract
Procédé pour la modification de la réfringence d'un oeil, consistant à choisir une correction dioptrique pour un oeil, sans compromis lié à la baisse de réfringence due à une réaction biologique découlant d'un changement du profil cornéen, puis à modifier le profil de la cornée de l'oeil considéré pour amener la réfringence de cet oeil à la dioptrie voulue (par exemple, au laser ou sur intervention chirurgicale) et, enfin, à limiter la régression du profil cornéen (due aux réactions biologiques parasites) environ à la dioptrie retenue en appliquant à la cornée une composition renfermant un agent capable de maîtriser la réaction biologique. L'agent peut être un anti-inflammatoire stéroïde ou non stéroïde ou bien un constituant de la membrane basale. L'objectif de la modification de réfringence est d'induire l'emmétropie. Le procédé décrit permet de corriger les troubles de réfringence/d'accommodation, comme la myopie, l'hyperopie, l'(a)stigmatisme, etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU58059/98A AU5805998A (en) | 1997-01-02 | 1997-12-29 | Method for changing the refractive power of an eye |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77803297A | 1997-01-02 | 1997-01-02 | |
| US08/778,032 | 1997-01-02 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1998029069A2 WO1998029069A2 (fr) | 1998-07-09 |
| WO1998029069A3 WO1998029069A3 (fr) | 1998-10-08 |
| WO1998029069B1 true WO1998029069B1 (fr) | 1998-11-12 |
Family
ID=25112096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/023794 WO1998029069A2 (fr) | 1997-01-02 | 1997-12-29 | Procede de modification de la refringence d'un oeil |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU5805998A (fr) |
| WO (1) | WO1998029069A2 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0002211D0 (sv) * | 2000-06-13 | 2000-06-13 | Synphora Ab | Methods and compositions for prevention of myopia |
| US6878694B2 (en) | 2000-12-20 | 2005-04-12 | Alcon, Inc. | Ophthalmic irrigating solution adapted for use in lasik surgery |
| WO2002049611A2 (fr) | 2000-12-20 | 2002-06-27 | Alcon, Inc. | Solution ophtalmique lubrifiante convenant a la chirurgie lasik |
| WO2008070848A2 (fr) * | 2006-12-07 | 2008-06-12 | Priavision, Inc. | Procédé et matériau d'augmentation de la structure cornéenne in situ |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3831604A (en) * | 1973-04-18 | 1974-08-27 | C Neefe | Method of reshaping the cornea |
| CA1016435A (fr) * | 1973-06-28 | 1977-08-30 | Charles W. Neefe | Moule concave permettant de reformer la cornee et d'eliminer toute mauvaise refraction |
| US4983580A (en) * | 1986-04-04 | 1991-01-08 | Allergan, Inc. | Methods and materials for use in corneal wound healing |
| WO1989004172A1 (fr) * | 1987-11-09 | 1989-05-18 | Chiron Ophthalmics Inc. | Procede et composition de cicatrisation de blessures |
| US4973466A (en) * | 1988-06-21 | 1990-11-27 | Chiron Ophthalmics, Inc. | Wound-healing dressings and methods |
| US5360611A (en) * | 1988-10-03 | 1994-11-01 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation |
| US5036046A (en) * | 1988-10-12 | 1991-07-30 | Eye Research Institute Of Retina Foundation, Inc. | Method for enhancing healing of corneal endothelial wounds |
| JPH07501320A (ja) * | 1991-10-11 | 1995-02-09 | ギリーズ，マーク・セドリック | インタ−フェロン・アルファによる眼線維症の治療 |
| US5270051A (en) * | 1991-10-15 | 1993-12-14 | Harris Donald H | Enzyme-orthokeratology |
| WO1994005322A1 (fr) * | 1992-09-04 | 1994-03-17 | Summit Technology, Inc. | Agent reducteur de l'activite des plasmines pour le traitement d'une plaie resultant de l'ablation superficielle de la cornee et procede de depistage associe |
| WO1995020969A1 (fr) * | 1994-02-04 | 1995-08-10 | University Of Southern California | Procede de prevention de la perte de keratocytes |
-
1997
- 1997-12-29 WO PCT/US1997/023794 patent/WO1998029069A2/fr active Application Filing
- 1997-12-29 AU AU58059/98A patent/AU5805998A/en not_active Abandoned
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