WO1998024410A3 - Controlled release matrix tablet and method for its preparation - Google Patents

Controlled release matrix tablet and method for its preparation Download PDF

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Publication number
WO1998024410A3
WO1998024410A3 PCT/JP1997/004385 JP9704385W WO9824410A3 WO 1998024410 A3 WO1998024410 A3 WO 1998024410A3 JP 9704385 W JP9704385 W JP 9704385W WO 9824410 A3 WO9824410 A3 WO 9824410A3
Authority
WO
WIPO (PCT)
Prior art keywords
controlled release
active ingredient
release matrix
matrix tablet
preparation
Prior art date
Application number
PCT/JP1997/004385
Other languages
French (fr)
Other versions
WO1998024410A2 (en
Inventor
Yoshinobu Fukumori
Hideki Ichikawa
Yoshitaka Mikami
Original Assignee
Schering Plough Kabushiki Kais
Yoshinobu Fukumori
Hideki Ichikawa
Yoshitaka Mikami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough Kabushiki Kais, Yoshinobu Fukumori, Hideki Ichikawa, Yoshitaka Mikami filed Critical Schering Plough Kabushiki Kais
Priority to AU51358/98A priority Critical patent/AU5135898A/en
Publication of WO1998024410A2 publication Critical patent/WO1998024410A2/en
Publication of WO1998024410A3 publication Critical patent/WO1998024410A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A controlled release matrix tablet comprising agglomerates of raw pharmaceutical particles, wherein said agglomerates are formed by coating said raw pharmaceutical particles with a binder and have an average particle diameter of not less than 25 νm but less than 200 νm, and a method for preparing such tablets. The tablet has a higher content of an active ingredient, can be produced by handling the active ingredient-containing particles in a tableting step in essentially the same manner irrespective of the differences in the physical properties of raw pharmaceutical particles, and exhibits a moderate sustained release property of the active ingredient after tableting.
PCT/JP1997/004385 1996-12-03 1997-12-02 Controlled release matrix tablet and method for its preparation WO1998024410A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU51358/98A AU5135898A (en) 1996-12-03 1997-12-02 Controlled release matrix tablet and method for its preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP32275096 1996-12-03
JP8/322750 1996-12-03

Publications (2)

Publication Number Publication Date
WO1998024410A2 WO1998024410A2 (en) 1998-06-11
WO1998024410A3 true WO1998024410A3 (en) 1998-08-20

Family

ID=18147230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/004385 WO1998024410A2 (en) 1996-12-03 1997-12-02 Controlled release matrix tablet and method for its preparation

Country Status (2)

Country Link
AU (1) AU5135898A (en)
WO (1) WO1998024410A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002574A1 (en) * 1977-12-08 1979-06-27 Beecham Group Plc Dispersions in particulate form, a process for making the dispersions and pharmaceutical compositions containing them
WO1984002843A1 (en) * 1983-01-26 1984-08-02 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
FR2552665A1 (en) * 1983-10-03 1985-04-05 Rotman Avner MICROENCAPSULE DRUG IN A SWEET MATRIX
US4710384A (en) * 1986-07-28 1987-12-01 Avner Rotman Sustained release tablets made from microcapsules
EP0436373A1 (en) * 1989-12-22 1991-07-10 Syntex Pharmaceuticals International Limited Process for making tablets containing spray-dried naproxen or naproxen sodium

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002574A1 (en) * 1977-12-08 1979-06-27 Beecham Group Plc Dispersions in particulate form, a process for making the dispersions and pharmaceutical compositions containing them
WO1984002843A1 (en) * 1983-01-26 1984-08-02 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
FR2552665A1 (en) * 1983-10-03 1985-04-05 Rotman Avner MICROENCAPSULE DRUG IN A SWEET MATRIX
US4710384A (en) * 1986-07-28 1987-12-01 Avner Rotman Sustained release tablets made from microcapsules
EP0436373A1 (en) * 1989-12-22 1991-07-10 Syntex Pharmaceuticals International Limited Process for making tablets containing spray-dried naproxen or naproxen sodium

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAFIEE-TEHRANI M ET AL: "FORMULATION OF CONTROLLED RELEASE LITHIUM CARBONATE TABLETS BY FLUID BED TECHNIQUE", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 39, no. 2, 1 April 1993 (1993-04-01), pages 87 - 91, XP000363223 *

Also Published As

Publication number Publication date
AU5135898A (en) 1998-06-29
WO1998024410A2 (en) 1998-06-11

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