WO1998021365A3 - Method for detection of metastatic prostate cancer - Google Patents

Method for detection of metastatic prostate cancer Download PDF

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Publication number
WO1998021365A3
WO1998021365A3 PCT/US1997/020948 US9720948W WO9821365A3 WO 1998021365 A3 WO1998021365 A3 WO 1998021365A3 US 9720948 W US9720948 W US 9720948W WO 9821365 A3 WO9821365 A3 WO 9821365A3
Authority
WO
WIPO (PCT)
Prior art keywords
prostate cancer
detection
metastatic prostate
polypeptide
rna
Prior art date
Application number
PCT/US1997/020948
Other languages
French (fr)
Other versions
WO1998021365A2 (en
Inventor
Donald J Tindall
Charles Y F Young
Daniel J Mccormick
George G Klee
Mohammad Saeed Saedi
Abhay Kumar
Harry G Rittenhouse
Robert L Wolfert
Original Assignee
Mayo Foundation
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation, Hybritech Inc filed Critical Mayo Foundation
Priority to AU52602/98A priority Critical patent/AU737659B2/en
Priority to CA002271770A priority patent/CA2271770A1/en
Priority to EP97947550A priority patent/EP0941368A2/en
Priority to JP52288898A priority patent/JP2001503991A/en
Publication of WO1998021365A2 publication Critical patent/WO1998021365A2/en
Publication of WO1998021365A3 publication Critical patent/WO1998021365A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

Prostate cancer is detected by determining the presence of prostate specific glandular Kallikrein (hK2) polypeptide or hK2 RNA in a physiological sample.
PCT/US1997/020948 1996-11-14 1997-11-14 Method for detection of metastatic prostate cancer WO1998021365A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU52602/98A AU737659B2 (en) 1996-11-14 1997-11-14 Method for detection of metastatic prostate cancer
CA002271770A CA2271770A1 (en) 1996-11-14 1997-11-14 Method for detection of metastatic prostate cancer
EP97947550A EP0941368A2 (en) 1996-11-14 1997-11-14 Method for detection of metastatic prostate cancer
JP52288898A JP2001503991A (en) 1996-11-14 1997-11-14 Methods for detecting metastatic prostate cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75935496A 1996-11-14 1996-11-14
US08/759,354 1996-11-14

Publications (2)

Publication Number Publication Date
WO1998021365A2 WO1998021365A2 (en) 1998-05-22
WO1998021365A3 true WO1998021365A3 (en) 1998-10-15

Family

ID=25055346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020948 WO1998021365A2 (en) 1996-11-14 1997-11-14 Method for detection of metastatic prostate cancer

Country Status (6)

Country Link
EP (1) EP0941368A2 (en)
JP (1) JP2001503991A (en)
CN (1) CN1238013A (en)
AU (1) AU737659B2 (en)
CA (1) CA2271770A1 (en)
WO (1) WO1998021365A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044940A2 (en) * 1999-01-28 2000-08-03 Gen-Probe Incorporated Nucleic acid sequences for detecting genetic markers for cancer in a biological sample
FI990382A0 (en) * 1999-02-23 1999-02-23 Arctic Partners Oy Ab New diagnostic method
US8663600B2 (en) 2005-02-17 2014-03-04 Diaprost Ab Diagnosis of prostate cancer
FR2906537A1 (en) * 2006-09-28 2008-04-04 Biomerieux Sa METHOD FOR IN VITRO DIAGNOSIS OF BRONCHO-PULMONARY CANCER BY DETECTION OF ALTERNATIVE MAJORITY TRANSCRIPTS OF KLK8 GENE ENCODING KALLICREIN 8 AND USE THEREOF FOR THE PROGNOSIS OF SURVIVAL
CA2853669C (en) 2011-10-28 2019-03-12 Fredax Ab Therapeutic agents and uses thereof
PL3071595T3 (en) 2013-11-19 2019-09-30 Fredax Ab Humanised anti kallikrein-2 antibody

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010343A1 (en) * 1992-10-29 1994-05-11 Thomas Jefferson University Methods of detecting micrometastasis of prostate cancer
WO1995028498A1 (en) * 1994-04-15 1995-10-26 The Trustees Of Columbia University In The City Of New York Method for molecular staging of prostate cancer
WO1995030758A1 (en) * 1994-05-10 1995-11-16 Mayo Foundation For Medical Education And Research Recombinant hk2 polypeptide
WO1996021042A2 (en) * 1995-01-04 1996-07-11 Trustees Of Boston University Primers for the pcr amplification of metastatic sequences
WO1996026272A1 (en) * 1995-02-24 1996-08-29 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010343A1 (en) * 1992-10-29 1994-05-11 Thomas Jefferson University Methods of detecting micrometastasis of prostate cancer
WO1995028498A1 (en) * 1994-04-15 1995-10-26 The Trustees Of Columbia University In The City Of New York Method for molecular staging of prostate cancer
WO1995030758A1 (en) * 1994-05-10 1995-11-16 Mayo Foundation For Medical Education And Research Recombinant hk2 polypeptide
WO1996021042A2 (en) * 1995-01-04 1996-07-11 Trustees Of Boston University Primers for the pcr amplification of metastatic sequences
WO1996026272A1 (en) * 1995-02-24 1996-08-29 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DEGUCHI ET AL.: "Detection of micrometastatic prostate cancer cells in lymph nodes by RT-PCR", CANCER RESEARCH, vol. 53, November 1993 (1993-11-01), pages 5350 - 5354, XP002059297 *
SAEDI M S ET AL: "OVEREXPRESSION OF A HUMAN PROSTATE-SPECIFIC GLANDULAR KALLIKREIN, HK2, IN E. COLI AND GENERATION OF ANTIBODIES", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 109, 1995, pages 237 - 241, XP002015421 *
SCHEDLICH L J ET AL: "PRIMARY STRUCTURE OF A HUMAN GLANDULAR KALLIKREIN GENE", DNA, vol. 6, no. 5, 1987, pages 429 - 437, XP002044466 *
TAKAYAMA ET AL.: "Newer applications of serum PSA in the management of prostate cancer", SEMINARS IN ONCOLOGY, vol. 21, no. 5, October 1994 (1994-10-01), pages 542 - 533, XP002059296 *
YOUNG C Y -F ET AL: "TISSUE-SPECIFIC AND HORMONAL REGULATION OF HUMAN PROSTATE-SPECIFIC GLANDULAR KALLIKREIN", BIOCHEMISTRY, vol. 31, no. 3, 1992, pages 818 - 824, XP002050778 *

Also Published As

Publication number Publication date
WO1998021365A2 (en) 1998-05-22
AU737659B2 (en) 2001-08-23
CA2271770A1 (en) 1998-05-22
EP0941368A2 (en) 1999-09-15
AU5260298A (en) 1998-06-03
JP2001503991A (en) 2001-03-27
CN1238013A (en) 1999-12-08

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