WO1998016645A3 - Compounds and methods for diagnosis of tuberculosis - Google Patents

Compounds and methods for diagnosis of tuberculosis Download PDF

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Publication number
WO1998016645A3
WO1998016645A3 PCT/US1997/018214 US9718214W WO9816645A3 WO 1998016645 A3 WO1998016645 A3 WO 1998016645A3 US 9718214 W US9718214 W US 9718214W WO 9816645 A3 WO9816645 A3 WO 9816645A3
Authority
WO
WIPO (PCT)
Prior art keywords
tuberculosis
polypeptides
compounds
methods
diagnosis
Prior art date
Application number
PCT/US1997/018214
Other languages
French (fr)
Other versions
WO1998016645A2 (en
Inventor
Steven G Reed
Yasir A W Skeiky
Davin C Dillon
Antonio Campos-Neto
Raymond Houghton
Thomas S Vedvick
Daniel R Twardzik
Michael J Lodes
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/818,111 external-priority patent/US6338852B1/en
Application filed by Corixa Corp filed Critical Corixa Corp
Priority to BR9712298-0A priority Critical patent/BR9712298A/en
Priority to AU47505/97A priority patent/AU4750597A/en
Priority to JP10518432A priority patent/JP2001500383A/en
Priority to EP97910030A priority patent/EP0934415A2/en
Priority to CA002268036A priority patent/CA2268036A1/en
Priority to IL12938997A priority patent/IL129389A0/en
Publication of WO1998016645A2 publication Critical patent/WO1998016645A2/en
Publication of WO1998016645A3 publication Critical patent/WO1998016645A3/en
Priority to NO991693A priority patent/NO991693L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
PCT/US1997/018214 1996-10-11 1997-10-07 Compounds and methods for diagnosis of tuberculosis WO1998016645A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR9712298-0A BR9712298A (en) 1996-10-11 1997-10-07 Polypeptide, DNA molecule, recombinant expression vector, host cell, process to detect infection by m. tuberculosis in a biological sample, diagnostic kit, monoclonal, and, polyclonal, and, fusion protein
AU47505/97A AU4750597A (en) 1996-10-11 1997-10-07 Compounds and methods for diagnosis of tuberculosis
JP10518432A JP2001500383A (en) 1996-10-11 1997-10-07 Compounds and methods for diagnosing tuberculosis
EP97910030A EP0934415A2 (en) 1996-10-11 1997-10-07 Compounds and methods for diagnosis of tuberculosis
CA002268036A CA2268036A1 (en) 1996-10-11 1997-10-07 Compounds and methods for diagnosis of tuberculosis
IL12938997A IL129389A0 (en) 1996-10-11 1997-10-07 Compounds and methods for diagnsosis of tuberculosis
NO991693A NO991693L (en) 1996-10-11 1999-04-09 Compounds and methods for the diagnosis of tuberculosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72962296A 1996-10-11 1996-10-11
US08/818,111 US6338852B1 (en) 1995-09-01 1997-03-13 Compounds and methods for diagnosis of tuberculosis
US08/818,111 1997-03-13
US08/729,622 1997-03-13

Publications (2)

Publication Number Publication Date
WO1998016645A2 WO1998016645A2 (en) 1998-04-23
WO1998016645A3 true WO1998016645A3 (en) 1998-08-06

Family

ID=27111919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/018214 WO1998016645A2 (en) 1996-10-11 1997-10-07 Compounds and methods for diagnosis of tuberculosis

Country Status (11)

Country Link
EP (1) EP0934415A2 (en)
JP (1) JP2001500383A (en)
AU (1) AU4750597A (en)
BR (1) BR9712298A (en)
CA (1) CA2268036A1 (en)
CZ (1) CZ126699A3 (en)
IL (2) IL129389A0 (en)
NO (1) NO991693L (en)
PL (1) PL333304A1 (en)
TR (1) TR199901569T2 (en)
WO (1) WO1998016645A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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US6991797B2 (en) 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
US6982085B2 (en) 1997-04-02 2006-01-03 Statens Serum Institut TB diagnostic based on antigens from M. tuberculosis
US6613881B1 (en) * 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
WO1999004005A1 (en) * 1997-07-16 1999-01-28 Institut Pasteur A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same
EP1484405A1 (en) * 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
US20030027774A1 (en) * 1999-03-18 2003-02-06 Ronald C. Hendrickson Tuberculosis antigens and methods of use therefor
DK1214088T3 (en) 1999-05-04 2009-08-24 Univ New Jersey Med Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
ATE354663T1 (en) * 1999-10-07 2007-03-15 Corixa Corp A MYCOBACTERIUM TUBERCULOSIS CODING SEQUENCE FOR EXPRESSING HETEROLOGUE PROTEINS
US7009042B1 (en) 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
US6316205B1 (en) 2000-01-28 2001-11-13 Genelabs Diagnostics Pte Ltd. Assay devices and methods of analyte detection
AU2001241738A1 (en) 2000-02-25 2001-09-03 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
PT1542732E (en) 2000-06-20 2009-11-06 Corixa Corp Fusion proteins of mycobacterium tuberculosis
WO2002004018A2 (en) * 2000-07-10 2002-01-17 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
AU2002317940B9 (en) 2001-06-22 2008-06-05 The Secretary Of State For Health Mycobacterial antigens expressed under low oxygen tension
EP2196473A1 (en) 2001-07-04 2010-06-16 Health Protection Agency Mycobacterial antigens expressed during latency
US7105319B2 (en) * 2001-07-25 2006-09-12 Tosoh Corporation Oligonucleotides for detecting tubercle bacillus and method therefor
GB0125535D0 (en) * 2001-10-24 2001-12-12 Microbiological Res Authority Mycobacterial genes down-regulated during latency
US7026465B2 (en) 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
US8475735B2 (en) 2004-11-01 2013-07-02 Uma Mahesh Babu Disposable immunodiagnostic test system
BRPI0518933A2 (en) 2004-11-16 2008-12-16 Crucell Holland B V E Aeras Gl replication defective recombinant adenovirus, recombinant polynucleotide vector, multivalent tuberculosis vaccine, and use of mycobacterium antigen tb10.4
EP2457926B1 (en) 2005-04-29 2014-09-24 GlaxoSmithKline Biologicals S.A. Novel method for preventing or treating M. tuberculosis infection
CA2616766A1 (en) * 2005-07-26 2007-02-01 University Of Medicine And Dentistry Of New Jersey Antibody profiles characteristic of tuberculosis state
CN100999550B (en) * 2006-01-10 2010-10-06 中国人民解放军第三○九医院 Tubercle branch bacillus fusion protein and application thereof
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker
EP2368568A1 (en) 2006-11-01 2011-09-28 Immport Therapeutics, INC. Compositions and methods for immunodominant antigens
EA201290590A1 (en) 2010-01-27 2013-03-29 Глаксосмитклайн Байолоджикалс С.А. MODIFIED TUBERCULOSIS ANTIGENS

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244539A1 (en) * 1973-07-13 1975-04-18 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
FR2265402A1 (en) * 1974-03-29 1975-10-24 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
EP0419355A1 (en) * 1989-09-19 1991-03-27 N.V. Innogenetics S.A. Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis
WO1992021758A1 (en) * 1991-06-07 1992-12-10 Institut Pasteur Mycobacterium proteins and applications
WO1994000493A1 (en) * 1992-06-29 1994-01-06 Archana Kapoor Membrane-associated immunogens of mycobacteria
WO1995001440A1 (en) * 1993-07-02 1995-01-12 Statens Seruminstitut Diagnostic skin test for tuberculosis
WO1995001441A1 (en) * 1993-07-02 1995-01-12 Statens Serumsinstitut Tuberculosis vaccine
WO1996023885A1 (en) * 1995-02-01 1996-08-08 Institut Pasteur Mycobacterial proteins, microorganisms producing same and uses of said proteins in vaccines and for detecting tuberculosis
WO1997009428A2 (en) * 1995-09-01 1997-03-13 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
WO1997009429A2 (en) * 1995-09-01 1997-03-13 Corixa Corporation Compounds and methods for diagnosis of tuberculosis

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244539A1 (en) * 1973-07-13 1975-04-18 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
FR2265402A1 (en) * 1974-03-29 1975-10-24 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
EP0419355A1 (en) * 1989-09-19 1991-03-27 N.V. Innogenetics S.A. Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis
WO1992021758A1 (en) * 1991-06-07 1992-12-10 Institut Pasteur Mycobacterium proteins and applications
WO1994000493A1 (en) * 1992-06-29 1994-01-06 Archana Kapoor Membrane-associated immunogens of mycobacteria
WO1995001440A1 (en) * 1993-07-02 1995-01-12 Statens Seruminstitut Diagnostic skin test for tuberculosis
WO1995001441A1 (en) * 1993-07-02 1995-01-12 Statens Serumsinstitut Tuberculosis vaccine
WO1996023885A1 (en) * 1995-02-01 1996-08-08 Institut Pasteur Mycobacterial proteins, microorganisms producing same and uses of said proteins in vaccines and for detecting tuberculosis
WO1997009428A2 (en) * 1995-09-01 1997-03-13 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
WO1997009429A2 (en) * 1995-09-01 1997-03-13 Corixa Corporation Compounds and methods for diagnosis of tuberculosis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANDERSEN A B ET AL: "STRUCTURE AND MAPPING OF ANTIGENIC DOMAINS OF PROTEIN ANTIGEN B, A 38,000-MOLECULAR-WEIGHT PROTEIN OF MYCOBACTERIUM TUBERCULOSIS", INFECTION AND IMMUNITY, vol. 57, no. 8, August 1989 (1989-08-01), pages 2481 - 2488, XP002026677 *
ANDERSEN P. ET AL.: "Identification of immunodominant antigens during infection with Mycobacterium tuberculosis", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 36, 1992, pages 823 - 831, XP002057751 *
AUSUBEL ET AL: "ISOLATION OF PROTEINS FOR MICROSEQUENCE ANALYSIS", CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, 1993, pages 10.19.01 - 10.19.12, XP002026411 *
ROMAIN ET AL: "PREPARATION OF TUBERCULIN ANTIGEN L", ANNALES DE L'INSTITUT PASTEUR / MICROBIOLOGIE, vol. 136B, 1985, pages 235 - 248, XP002026409 *
YOUNG D B ET AL: "SCREENING OF A RECOMBINANT MYCOBACTERIAL DNA LIBRARY WITH POLYCLONAL ANTISERUM AND MOLECULAR WEIGHT ANALYSIS OF EXPRESSED ANTIGENS", INFECTION AND IMMUNITY, vol. 55, no. 6, June 1987 (1987-06-01), pages 1421 - 1425, XP002026410 *

Also Published As

Publication number Publication date
IL129389A0 (en) 2000-02-17
AU4750597A (en) 1998-05-11
CA2268036A1 (en) 1998-04-23
IL121936A0 (en) 1998-03-10
PL333304A1 (en) 1999-11-22
CZ126699A3 (en) 1999-09-15
WO1998016645A2 (en) 1998-04-23
EP0934415A2 (en) 1999-08-11
NO991693L (en) 1999-06-09
NO991693D0 (en) 1999-04-09
BR9712298A (en) 2000-10-24
TR199901569T2 (en) 2000-12-21
JP2001500383A (en) 2001-01-16

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