WO1998007844A3 - Screening assay for the identification of agents which alter expression of pth-rp - Google Patents
Screening assay for the identification of agents which alter expression of pth-rp Download PDFInfo
- Publication number
- WO1998007844A3 WO1998007844A3 PCT/US1997/014836 US9714836W WO9807844A3 WO 1998007844 A3 WO1998007844 A3 WO 1998007844A3 US 9714836 W US9714836 W US 9714836W WO 9807844 A3 WO9807844 A3 WO 9807844A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pth
- agents
- expression
- assayable product
- production
- Prior art date
Links
- 238000007423 screening assay Methods 0.000 title 1
- 108700008625 Reporter Genes Proteins 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 108700039691 Genetic Promoter Regions Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 102100036899 Parathyroid hormone-related protein Human genes 0.000 abstract 1
- 101710123753 Parathyroid hormone-related protein Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000000423 cell based assay Methods 0.000 abstract 1
- 239000013043 chemical agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000004565 tumor cell growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU41587/97A AU4158797A (en) | 1996-08-23 | 1997-08-22 | Screening assay for the identification of agents which alter expression of pth-rp |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2521596P | 1996-08-23 | 1996-08-23 | |
US60/025,215 | 1996-08-23 | ||
US08/915,868 US5914233A (en) | 1996-08-23 | 1997-08-21 | Screening assay for the identification of agents which alter expression of PTH-rP |
US08/915,868 | 1997-08-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998007844A2 WO1998007844A2 (en) | 1998-02-26 |
WO1998007844A3 true WO1998007844A3 (en) | 1998-08-27 |
Family
ID=26699451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/014836 WO1998007844A2 (en) | 1996-08-23 | 1997-08-22 | SCREENING ASSAY FOR THE IDENTIFICATION OF AGENTS WHICH ALTER EXPRESSION OF PTH-rP |
Country Status (3)
Country | Link |
---|---|
US (2) | US5914233A (en) |
AU (1) | AU4158797A (en) |
WO (1) | WO1998007844A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000005416A2 (en) * | 1998-07-23 | 2000-02-03 | Georgetown University | Fgf-bp promoter sequences as sensors of drug effects |
DE69924027T2 (en) * | 1998-09-04 | 2005-07-21 | Aventis Pharmaceuticals Inc. | LUCIFERASE REPORTER TEST PROCEDURE FOR PARATHYROIDHORMONE COMPOUNDS |
EP1385994A2 (en) * | 2001-04-02 | 2004-02-04 | Bayer HealthCare AG | Method for specifically detecting, isolating and characterizing cells from body samples by transfecting nucleic acid constructs |
CA2496761C (en) | 2002-08-21 | 2015-06-02 | Revivicor, Inc. | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
EP1393720A1 (en) * | 2002-08-27 | 2004-03-03 | Universiteit Utrecht | Vesicle-encapsulated corticosteroids for treatment of cancer |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
EP1601576A4 (en) | 2003-03-03 | 2007-12-05 | Univ Columbia | Ligand/binding partner bio-labeling systems |
WO2006014899A2 (en) | 2004-07-26 | 2006-02-09 | Dow Global Technologies Inc. | Process for improved protein expression by strain engineering |
EP3138403A1 (en) | 2005-08-09 | 2017-03-08 | Revivicor, Inc. | Transgenic ungulates expressing ctla4-ig and uses thereof |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
AU2008245696B2 (en) | 2007-04-27 | 2013-11-07 | Pelican Technology Holdings, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
WO2012170417A2 (en) | 2011-06-06 | 2012-12-13 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022790A1 (en) * | 1995-01-23 | 1996-08-01 | Xenotech Incorporated | Composition to ameliorate osteolysis and metastasis |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0487298A3 (en) * | 1990-11-21 | 1992-12-16 | Schering Corporation | Human gamma interferon antagonist/agonist screen |
-
1997
- 1997-08-21 US US08/915,868 patent/US5914233A/en not_active Expired - Fee Related
- 1997-08-22 WO PCT/US1997/014836 patent/WO1998007844A2/en active Application Filing
- 1997-08-22 AU AU41587/97A patent/AU4158797A/en not_active Abandoned
-
2001
- 2001-06-11 US US09/879,445 patent/US20020061509A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022790A1 (en) * | 1995-01-23 | 1996-08-01 | Xenotech Incorporated | Composition to ameliorate osteolysis and metastasis |
Non-Patent Citations (8)
Title |
---|
ALAM J ET AL: "REPORTER GENES: APPLICATION TO THE STUDY OF MAMMALIAN GENE TRANSCRIPTION", ANALYTICAL BIOCHEMISTRY, vol. 188, no. 2, 1 August 1990 (1990-08-01), pages 245 - 254, XP000563914 * |
BOUIZAR ET AL.: "POLYMERASE CHAIN REACTION ANALYSIS OF PARATHYROID HORMONE-RELATED PROTEIN GENE EXPRESSION IN BREAST CANCER PATIENTS AND OCCURRENCE OF BONE METASTASES", CANCER RESEARCH, vol. 53, 1993, pages 5076 - 5078, XP002051653 * |
M.L. CASEY ET AL.: "Regulation of parathyroid hormone-related protein gene expression in human endometrial stromal cells in culture.", J. CLIN. ENDOCRINOL. METAB., vol. 77, no. 1, 1993, pages 188 - 194, XP002068021 * |
MANGIN ET AL.: "IDENTIFICATION OF AN UP-STREAM PROMOTER OF THE HUMAN PARATHYROID HORMONE-RELATED PEPTIDE GENE", MOL. ENDOCRINOLOGY, vol. 4, 1990, pages 851 - 858, XP002051652 * |
S .BUDAVARI , EDITOR: "the merck index", 1996, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION, NJ, USA, XP002068022 * |
S BUDAVARI, EDITOR: "the merck index", 1996, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION, NJ,USA, XP002068023 * |
WYSOLMERSKI ET AL.: "TRANSACTIVATION OF THE PTHRP GENE IN SQUAMOUS CARCINOMAS PREDICTS THE OCCURRENCE OF HYPERCALCEMIA IN ATHYMIC MICE", CANCER RESEARCH, vol. 56, 1996, pages 1043 - 1049, XP002051650 * |
YU ET AL.: "VITAMIN D ANALOGS: NEW THERAPEUTIC AGENTS FOR THE TREATMENT OF SQUAMOUS CANCER AND ITS ASSOCIATED HYPERCALCEMIA", ANTI-CANCER DRUGS, vol. 6, 1995, pages 101 - 108, XP002051651 * |
Also Published As
Publication number | Publication date |
---|---|
US20020061509A1 (en) | 2002-05-23 |
AU4158797A (en) | 1998-03-06 |
US5914233A (en) | 1999-06-22 |
WO1998007844A2 (en) | 1998-02-26 |
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