WO1998005770A3 - Antisense rna with a secondary structure - Google Patents
Antisense rna with a secondary structure Download PDFInfo
- Publication number
- WO1998005770A3 WO1998005770A3 PCT/DE1997/001691 DE9701691W WO9805770A3 WO 1998005770 A3 WO1998005770 A3 WO 1998005770A3 DE 9701691 W DE9701691 W DE 9701691W WO 9805770 A3 WO9805770 A3 WO 9805770A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antisense rna
- secondary structure
- combination
- rnase
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01028—Chloramphenicol O-acetyltransferase (2.3.1.28)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97936610A EP0918853A2 (en) | 1996-08-07 | 1997-08-05 | Antisense rna with a secondary structure |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1996131919 DE19631919C2 (en) | 1996-08-07 | 1996-08-07 | Anti-sense RNA with secondary structure |
DE19631919.6 | 1996-08-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998005770A2 WO1998005770A2 (en) | 1998-02-12 |
WO1998005770A3 true WO1998005770A3 (en) | 1998-03-26 |
Family
ID=7802056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1997/001691 WO1998005770A2 (en) | 1996-08-07 | 1997-08-05 | Antisense rna with a secondary structure |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0918853A2 (en) |
DE (1) | DE19631919C2 (en) |
WO (1) | WO1998005770A2 (en) |
Cited By (5)
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US7888325B2 (en) | 1999-01-28 | 2011-02-15 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
US8101584B2 (en) | 1999-01-30 | 2012-01-24 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a given gene |
US9051566B2 (en) | 2001-01-31 | 2015-06-09 | Alnylam Pharmaceuticals, Inc. | Post-transcriptional gene silencing using expressed double stranded RNA |
US9422564B2 (en) | 2002-12-23 | 2016-08-23 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
US9587240B2 (en) | 2001-01-09 | 2017-03-07 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
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AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
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US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
DE10100586C1 (en) * | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Inhibiting gene expression in cells, useful for e.g. treating tumors, by introducing double-stranded complementary oligoRNA having unpaired terminal bases |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992019732A1 (en) * | 1991-04-25 | 1992-11-12 | Genset | Closed sense and antisense oligonucleotides and uses thereof |
WO1994001550A1 (en) * | 1992-07-02 | 1994-01-20 | Hybridon, Inc. | Self-stabilized oligonucleotides as therapeutic agents |
EP0592685A1 (en) * | 1992-04-17 | 1994-04-20 | Kirin Beer Kabushiki Kaisha | Plant resistant to two or more viruses and preparation thereof |
WO1994023026A1 (en) * | 1993-03-26 | 1994-10-13 | Genset | Staple and semi-staple oligonucleotides, method of preparation and applications |
WO1995010607A1 (en) * | 1993-10-14 | 1995-04-20 | The Regents Of The University Of California | Antisense oligonucleotide generators |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2273932A (en) * | 1992-11-24 | 1994-07-06 | Stiefel Laboratories | Stable oligonucleotides |
-
1996
- 1996-08-07 DE DE1996131919 patent/DE19631919C2/en not_active Expired - Fee Related
-
1997
- 1997-08-05 EP EP97936610A patent/EP0918853A2/en not_active Withdrawn
- 1997-08-05 WO PCT/DE1997/001691 patent/WO1998005770A2/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992019732A1 (en) * | 1991-04-25 | 1992-11-12 | Genset | Closed sense and antisense oligonucleotides and uses thereof |
EP0592685A1 (en) * | 1992-04-17 | 1994-04-20 | Kirin Beer Kabushiki Kaisha | Plant resistant to two or more viruses and preparation thereof |
WO1994001550A1 (en) * | 1992-07-02 | 1994-01-20 | Hybridon, Inc. | Self-stabilized oligonucleotides as therapeutic agents |
WO1994023026A1 (en) * | 1993-03-26 | 1994-10-13 | Genset | Staple and semi-staple oligonucleotides, method of preparation and applications |
WO1995010607A1 (en) * | 1993-10-14 | 1995-04-20 | The Regents Of The University Of California | Antisense oligonucleotide generators |
Non-Patent Citations (4)
Title |
---|
HELENE C ET AL: "LA STRATEGIE ANTISENS: NOUVELLES APPROCHES THERAPEUTIQUES", MEDECINE SCIENCES, vol. 10, no. 3, 1 March 1994 (1994-03-01), pages 253 - 273, XP000576223 * |
NELLEN, W. & LICHTENSTEIN, C.: "WHAT MAKES AN MESSENGER-RNA ANTI-SENSE-ITIVE ?", TRENDS IN BIOCHEMICAL SCIENCES, (NOV 1993) VOL. 18, NO. 11, PP. 419-423., XP002049385 * |
ROTONDO, G. & FRENDEWEY, D.: "PURIFICATION AND CHARACTERIZATION OF THE PAC1 RIBONUCLEASE OF SCHIZOSACCHAROMYCES-POMBE", NUCLEIC ACIDS RESEARCH, (15 JUN 1996) VOL. 24, NO. 12, PP. 2377-2386., XP002049388 * |
URATA, H. ET AL.: "NMR study of a heterochiral DNA: stable Watson-Crick-type base-pairing between the enantiomeric residues", J. AM. CHEM. SOC. (1993), 115, 9852-3, XP002052970 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7888325B2 (en) | 1999-01-28 | 2011-02-15 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
US8148345B2 (en) | 1999-01-28 | 2012-04-03 | Georgia Health Sciences University Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
US8101584B2 (en) | 1999-01-30 | 2012-01-24 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a given gene |
US8101742B2 (en) | 1999-01-30 | 2012-01-24 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a given gene |
US8114981B2 (en) | 1999-01-30 | 2012-02-14 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a given gene |
US8114851B2 (en) | 1999-01-30 | 2012-02-14 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a given gene |
US8168776B2 (en) | 1999-01-30 | 2012-05-01 | Alnylam Pharmaceuticals, Inc. | Method for making a 21 nucleotide double stranded RNA chemically linked at one end |
US8183362B2 (en) | 1999-01-30 | 2012-05-22 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a given gene |
US8729037B2 (en) | 1999-01-30 | 2014-05-20 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a given gene |
US9587240B2 (en) | 2001-01-09 | 2017-03-07 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
US9051566B2 (en) | 2001-01-31 | 2015-06-09 | Alnylam Pharmaceuticals, Inc. | Post-transcriptional gene silencing using expressed double stranded RNA |
US9422564B2 (en) | 2002-12-23 | 2016-08-23 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
Also Published As
Publication number | Publication date |
---|---|
WO1998005770A2 (en) | 1998-02-12 |
DE19631919A1 (en) | 1998-02-12 |
DE19631919C2 (en) | 1998-07-16 |
EP0918853A2 (en) | 1999-06-02 |
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