WO1998004589A3 - Production of recombinant plasma gelsolin containing a disulfide bond - Google Patents

Production of recombinant plasma gelsolin containing a disulfide bond Download PDF

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Publication number
WO1998004589A3
WO1998004589A3 PCT/US1997/013277 US9713277W WO9804589A3 WO 1998004589 A3 WO1998004589 A3 WO 1998004589A3 US 9713277 W US9713277 W US 9713277W WO 9804589 A3 WO9804589 A3 WO 9804589A3
Authority
WO
WIPO (PCT)
Prior art keywords
gelsolin
disulfide bond
production
plasma gelsolin
recombinant plasma
Prior art date
Application number
PCT/US1997/013277
Other languages
French (fr)
Other versions
WO1998004589A2 (en
Inventor
R Blake Pepinsky
Stephan Miller
Karen Hurkmans
Dingyi Wen
Original Assignee
Biogen Inc
R Blake Pepinsky
Stephan Miller
Karen Hurkmans
Dingyi Wen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc, R Blake Pepinsky, Stephan Miller, Karen Hurkmans, Dingyi Wen filed Critical Biogen Inc
Priority to AU38174/97A priority Critical patent/AU3817497A/en
Publication of WO1998004589A2 publication Critical patent/WO1998004589A2/en
Publication of WO1998004589A3 publication Critical patent/WO1998004589A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A method is provided for producing recombinant gelsolin containing a disulfide bond. The oxidized gelsolin may be produced by treating intracellular recombinant gelsolin with an oxidant, or by denaturing gelsolin and then refolding gelsolin.
PCT/US1997/013277 1996-07-30 1997-07-30 Production of recombinant plasma gelsolin containing a disulfide bond WO1998004589A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38174/97A AU3817497A (en) 1996-07-30 1997-07-30 Production of recombinant plasma gelsolin containing a disulfide bond

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2279296P 1996-07-30 1996-07-30
US60/022,792 1996-07-30

Publications (2)

Publication Number Publication Date
WO1998004589A2 WO1998004589A2 (en) 1998-02-05
WO1998004589A3 true WO1998004589A3 (en) 1998-03-26

Family

ID=21811477

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/013277 WO1998004589A2 (en) 1996-07-30 1997-07-30 Production of recombinant plasma gelsolin containing a disulfide bond

Country Status (2)

Country Link
AU (1) AU3817497A (en)
WO (1) WO1998004589A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101314461B1 (en) * 2004-05-12 2013-10-07 더 브리검 앤드 우먼즈 하스피털, 인크. Use of gelsolin to treat infections
HUE056086T2 (en) 2006-03-15 2022-01-28 Brigham & Womens Hospital Inc Use of gelsolin to diagnose and treat inflammatory diseases
HUE032875T2 (en) 2008-01-25 2017-11-28 Massachusetts Gen Hospital Diagnostic and therapeutic uses of gelsolin in renal failure

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0312358A2 (en) * 1987-10-14 1989-04-19 Mallinckrodt Veterinary, Inc. Method for promoting intramolecular disulfide bond formation in recombinant proteins contained in a denaturant solution
WO1991017170A1 (en) * 1990-05-04 1991-11-14 Biogen, Inc. Multimeric gelsolin fusion constructs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0312358A2 (en) * 1987-10-14 1989-04-19 Mallinckrodt Veterinary, Inc. Method for promoting intramolecular disulfide bond formation in recombinant proteins contained in a denaturant solution
WO1991017170A1 (en) * 1990-05-04 1991-11-14 Biogen, Inc. Multimeric gelsolin fusion constructs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALLEN PG: "Functional consequences of disulfide bond formation in gelsolin.", FEBS LETT, JAN 13 1997, 401 (1) P89-94, NETHERLANDS, XP002045562 *
BURTNICK L D ET AL: "The structure of horse plasma gelsolin to 2.5. A", BIOPHYSICAL JOURNAL, 70 (2 PART 2). 1996. A14., XP002045564 *
ITO H ET AL: "Affinity chromatography of human plasma gelsolin with polyphosphate compounds on immobilized Cibacron Blue F3GA.", J CHROMATOGR, APR 6 1990, 526 (2) P397-406, NETHERLANDS, XP002045565 *
WEN D ET AL: "The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure.", BIOCHEMISTRY, JUL 30 1996, 35 (30) P9700-9, UNITED STATES, XP002045563 *

Also Published As

Publication number Publication date
WO1998004589A2 (en) 1998-02-05
AU3817497A (en) 1998-02-20

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