WO1998001460A8 - Brca1 compositions and methods for the diagnosis and treatment of breast cancer - Google Patents

Brca1 compositions and methods for the diagnosis and treatment of breast cancer

Info

Publication number
WO1998001460A8
WO1998001460A8 PCT/US1997/011946 US9711946W WO9801460A8 WO 1998001460 A8 WO1998001460 A8 WO 1998001460A8 US 9711946 W US9711946 W US 9711946W WO 9801460 A8 WO9801460 A8 WO 9801460A8
Authority
WO
WIPO (PCT)
Prior art keywords
brca1
methods
compositions
diagnosis
treatment
Prior art date
Application number
PCT/US1997/011946
Other languages
French (fr)
Other versions
WO1998001460A1 (en
WO1998001460A9 (en
Inventor
Wen-Hwa Lee
Yumay Chen
Chi-Fen Chen
Phang-Lang Chen
Andrew A Farmer
Diane C Jones
D Craig Allred
C Kent Osborne
Original Assignee
Univ Texas
Lee Wen Hwa
Yumay Chen
Chen Chi Fen
Chen Phang Lang
Andrew A Farmer
Diane C Jones
D Craig Allred
C Kent Osborne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Lee Wen Hwa, Yumay Chen, Chen Chi Fen, Chen Phang Lang, Andrew A Farmer, Diane C Jones, D Craig Allred, C Kent Osborne filed Critical Univ Texas
Priority to AU36550/97A priority Critical patent/AU736210B2/en
Priority to JP50534598A priority patent/JP2002513272A/en
Priority to NZ333635A priority patent/NZ333635A/en
Priority to EP97933344A priority patent/EP0918788A4/en
Publication of WO1998001460A1 publication Critical patent/WO1998001460A1/en
Publication of WO1998001460A9 publication Critical patent/WO1998001460A9/en
Publication of WO1998001460A8 publication Critical patent/WO1998001460A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed are methods and compositions relating to the diagnosis and treatment of breast and related cancers. Compositions and methods for the detection of the BRCA1 gene product in vivo and in vitro are disclosed, as well as methods for diagnosing aberrant localization of BRCA1 protein in cells using anti-BRCA1 antibodies. Also disclosed are methods for identifying BRCA1-associated proteins which function in the proper translocation of the BRCA1 gene product to the cell nucleus.

Description

FOR THE PURPOSES OF INFORMATION ONLY
Codes used to identify States party to the PCT on the front pages of pamphlets publishing international applications under the PCT.
AL Albania ES Spain LS Lesotho SI Slovenia
AM Armenia FI Finland LT Lithuania SK Slovakia
AT Austria FR France LU Luxembourg SN Senegal
AU Australia GA Gabon LV Latvia sz Swaziland
AZ Azerbaijan GB United Kingdom MC Monaco TD Chad
BA Bosnia and Herzegovina GE Georgia MD Republic of Moldova TG Togo
BB Barbados GH Ghana MG Madagascar TJ Tajikistan
BE Belgium GN Guinea MK The former Yugoslav TM Turkmenistan
BF Burkina Faso GR Greece Republic of Macedonia TR Turkey
BG Bulgaria HU Hungary ML Mali TT Tπnidad and Tobago
BJ Benin IE Ireland MN Mongolia UA Ukraine
BR Brazil IL Israel MR Mauritania UG Uganda
BY Belarus IS Iceland MW Malawi US United States of America
CA Canada IT Italy MX Mexico uz Uzbekistan
CF Central African Republic JP Japan NE Niger VN Viet Nam
CG Congo KE Kenya NL Netherlands YU Yugoslavia
CH Switzerland KG Kyrgyzstan NO Norway ZW Zimbabwe
Cl Cδte d'lvoire KP Democratic People's NZ New Zealand
CM Cameroon Republic of Korea PL Poland
CN China KR Republic of Korea PT Portugal cu Cuba KZ Kazakstan RO Romania
CZ Czech Republic LC Saint Lucia RU Russian Federation
DE Germany LI Liechtenstein SD Sudan
DK Denmark LK Sπ Lanka SE Sweden
EE Estonia LR Libeπa SG Singapore
PCT/US1997/011946 1996-07-08 1997-07-08 Brca1 compositions and methods for the diagnosis and treatment of breast cancer WO1998001460A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU36550/97A AU736210B2 (en) 1996-07-08 1997-07-08 Brca1 compositions and methods for the diagnosis and treatment of breast cancer
JP50534598A JP2002513272A (en) 1996-07-08 1997-07-08 BRCA1 compositions and methods for diagnosis and treatment of breast cancer
NZ333635A NZ333635A (en) 1996-07-08 1997-07-08 BRCA1 associated proteins and peptides and the nucleotide encoding such proteins
EP97933344A EP0918788A4 (en) 1996-07-08 1997-07-08 Brca1 compositions and methods for the diagnosis and treatment of breast cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1586396P 1996-07-08 1996-07-08
US60/015,863 1996-07-08

Publications (3)

Publication Number Publication Date
WO1998001460A1 WO1998001460A1 (en) 1998-01-15
WO1998001460A9 WO1998001460A9 (en) 1998-04-23
WO1998001460A8 true WO1998001460A8 (en) 2000-01-06

Family

ID=21774065

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/011946 WO1998001460A1 (en) 1996-07-08 1997-07-08 Brca1 compositions and methods for the diagnosis and treatment of breast cancer

Country Status (7)

Country Link
EP (1) EP0918788A4 (en)
JP (1) JP2002513272A (en)
KR (1) KR20000023600A (en)
AU (1) AU736210B2 (en)
CA (1) CA2259154A1 (en)
NZ (1) NZ333635A (en)
WO (1) WO1998001460A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005968A1 (en) 1996-08-02 1998-02-12 The Wistar Institute Of Anatomy And Biology Brca1 associated protein (bap-1) and uses therefor
WO2001025255A2 (en) * 1999-10-07 2001-04-12 Baylor College Of Medicine Novel zinc finger protein
US20050065333A1 (en) * 2001-04-27 2005-03-24 Arun Seth Breast cancer-associated genes and uses thereof
KR100468466B1 (en) * 2001-08-25 2005-01-27 주식회사 랩 지노믹스 Breast and ovarian cancers suseceptibility mutations of BRCA 1 and BRCA 2, and detection method using them
EP1436624B1 (en) * 2001-09-12 2012-03-21 The Walter And Eliza Hall Institute Of Medical Research A method of diagnosis and treatment and agents useful for same
CN111253483B (en) * 2020-03-02 2021-07-30 江苏莱森生物科技研究院有限公司 anti-BRCA 1 monoclonal antibody and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019369A1 (en) * 1994-01-14 1995-07-20 Vanderbilt University Method for detection and treatment of breast cancer
US5756294A (en) * 1995-09-25 1998-05-26 Oncormed, Inc. Susceptibility mutation for breast and ovarian cancer
US5654155A (en) * 1996-02-12 1997-08-05 Oncormed, Inc. Consensus sequence of the human BRCA1 gene

Also Published As

Publication number Publication date
JP2002513272A (en) 2002-05-08
CA2259154A1 (en) 1998-01-15
KR20000023600A (en) 2000-04-25
AU3655097A (en) 1998-02-02
EP0918788A4 (en) 2002-02-13
NZ333635A (en) 2000-06-23
WO1998001460A1 (en) 1998-01-15
EP0918788A1 (en) 1999-06-02
AU736210B2 (en) 2001-07-26

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