WO1997031934A3 - Neue metabolisierbare lipopolyamine, deren darstellung und anwendung - Google Patents

Neue metabolisierbare lipopolyamine, deren darstellung und anwendung Download PDF

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Publication number
WO1997031934A3
WO1997031934A3 PCT/EP1997/000973 EP9700973W WO9731934A3 WO 1997031934 A3 WO1997031934 A3 WO 1997031934A3 EP 9700973 W EP9700973 W EP 9700973W WO 9731934 A3 WO9731934 A3 WO 9731934A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipopolyamines
preparation
metabolizable
novel
novel metabolizable
Prior art date
Application number
PCT/EP1997/000973
Other languages
English (en)
French (fr)
Other versions
WO1997031934A2 (de
Inventor
Stephan Koenig
Roland Kloesel
Original Assignee
Chemicon Lab Gmbh
Stephan Koenig
Roland Kloesel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemicon Lab Gmbh, Stephan Koenig, Roland Kloesel filed Critical Chemicon Lab Gmbh
Publication of WO1997031934A2 publication Critical patent/WO1997031934A2/de
Publication of WO1997031934A3 publication Critical patent/WO1997031934A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Die vorliegende Erfindung betrifft neue metabolisierbare Lipopolyamine (einschließlich deren Salze), sowie deren Herstellung und Anwendung. Diese neuen Verbindungen ermöglichen zum Beispiel die Einschleusung von biologisch aktiven Materialien, wie zum Beispiel von DNA, Antisense-DNA/RNA, Ribozymen, antiviralen Wirkstoffen, Proteinen und Peptiden in eukaryotische Zellen.
PCT/EP1997/000973 1996-02-29 1997-02-28 Neue metabolisierbare lipopolyamine, deren darstellung und anwendung WO1997031934A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1996107686 DE19607686A1 (de) 1996-02-29 1996-02-29 Neue metabolisierbare Lipopolyamine, deren Darstellung und Anwendung
DE19607686.2 1996-02-29

Publications (2)

Publication Number Publication Date
WO1997031934A2 WO1997031934A2 (de) 1997-09-04
WO1997031934A3 true WO1997031934A3 (de) 1997-12-24

Family

ID=7786789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/000973 WO1997031934A2 (de) 1996-02-29 1997-02-28 Neue metabolisierbare lipopolyamine, deren darstellung und anwendung

Country Status (2)

Country Link
DE (1) DE19607686A1 (de)
WO (1) WO1997031934A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939401A (en) * 1994-12-09 1999-08-17 Genzyme Corporation Cationic amphiphile compositions for intracellular delivery of therapeutic molecules
US6383814B1 (en) 1994-12-09 2002-05-07 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US6331524B1 (en) 1994-12-09 2001-12-18 Genzyme Corporation Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy
US5948767A (en) * 1994-12-09 1999-09-07 Genzyme Corporation Cationic amphiphile/DNA complexes
FR2760193B1 (fr) 1997-02-28 1999-05-28 Transgene Sa Lipides et complexes de lipides cationiques et de substances actives, notamment pour la transfection de cellules
CA2299429C (en) 1997-08-13 2010-04-20 Biontex Laboratories Gmbh New lipopolyamines,their preparation and the use thereof
GB9918670D0 (en) 1999-08-06 1999-10-13 Celltech Therapeutics Ltd Biological product
EP2765193B1 (de) 2011-10-07 2017-08-09 Mie University Chimärer antigenrezeptor
CZ303963B6 (cs) * 2012-01-13 2013-07-17 Ústav organické chemie a biochemie Akademie ved CR, v.v.i. Lipopolyaminy sperminového typu pro konstrukci liposomálních transfekcních systému
CA2995036A1 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Tunable endogenous protein degradation
US11052111B2 (en) 2015-12-08 2021-07-06 Chimera Bioengineering, Inc. Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses
JP7045378B2 (ja) 2016-09-01 2022-03-31 キメラ・バイオエンジニアリング，インコーポレーテッド Ｇｏｌｄ最適化ＣＡＲ Ｔ細胞
WO2018148440A1 (en) 2017-02-08 2018-08-16 Dana-Farber Cancer Institute, Inc. Regulating chimeric antigen receptors
WO2019217253A1 (en) 2018-05-07 2019-11-14 Children's Hospital Medical Center Chimeric polypeptides, nucleic acid molecules, cells, and related methods
CA3137397A1 (en) 2019-04-19 2020-10-22 Chugai Seiyaku Kabushiki Kaisha Chimeric receptor that recognizes engineered site in antibody
TW202112808A (zh) 2019-06-05 2021-04-01 日商中外製藥股份有限公司 抗體切斷部位結合分子
AU2021317974A1 (en) 2020-07-31 2023-03-16 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical Composition comprising Cell Expressing Chimeric Receptor
EP4310188A1 (de) 2021-03-17 2024-01-24 Daiichi Sankyo Company, Limited Für chimären rezeptor für anti-acetylcholinrezeptor-autoantikörper kodierendes gen
WO2022214887A1 (en) 2021-04-08 2022-10-13 Phosphogam, Llc Methods and compositions for enhancing the cytotoxicity of gamma/delta-t cells

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001841A1 (en) * 1994-07-08 1996-01-25 Gilead Sciences, Inc. Cationic lipids for delivery of nucleic acids to cells
WO1996018372A2 (en) * 1994-12-09 1996-06-20 Genzyme Corporation Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
WO1996040265A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Stabilization of polynucleotide complexes
WO1996040264A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Separation of active complexes
WO1996041873A1 (en) * 1995-06-09 1996-12-27 The Regents Of The University Of California Dry powder formulations of polynucleotide complexes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4446937C2 (de) * 1994-12-28 1998-09-24 Max Delbrueck Centrum Neues Cholesterolderivat, dessen Herstellung und Verwendung für den liposomalen Gentransfer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001841A1 (en) * 1994-07-08 1996-01-25 Gilead Sciences, Inc. Cationic lipids for delivery of nucleic acids to cells
WO1996001840A1 (en) * 1994-07-08 1996-01-25 Gilead Sciences, Inc. Cationic lipids for delivery of nucleic acids to cells
WO1996018372A2 (en) * 1994-12-09 1996-06-20 Genzyme Corporation Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
WO1996040265A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Stabilization of polynucleotide complexes
WO1996040264A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Separation of active complexes
WO1996041873A1 (en) * 1995-06-09 1996-12-27 The Regents Of The University Of California Dry powder formulations of polynucleotide complexes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BULL. SOC. CHIM. BELG., vol. 101, no. 11, 1992, pages 935 - 943 *
CHEMICAL ABSTRACTS, vol. 118, no. 19, 10 May 1993, Columbus, Ohio, US; abstract no. 192093, BRUNNER H ET AL: "Synthesis and antitumor activity of platinum(II) complexes of cholesterol derivatives" page 995; column 1; XP002032045 *
REMY, JEAN-SERGE ET AL: "Gene Transfer with a Series of Lipophilic DNA-Binding Molecules", BIOCONJUGATE CHEM. (1994), 5(6), 647-54 CODEN: BCCHES;ISSN: 1043-1802, 1994, XP000484178 *
WANG J ET AL: "SYNTHESIS OF MULTIVALENT CATIONIC CHOLESTERYL LIPIDS FOR USE AS GENE DELIVERY VEHICLES", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE BIOACTIVE MATERIALS, no. 22, 1995, pages 414/415, XP000607562 *

Also Published As

Publication number Publication date
DE19607686A1 (de) 1997-09-04
WO1997031934A2 (de) 1997-09-04

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